Generic Voveran SR (Diclofenac)

Introduction

Voveran SR is a sustained-release oral tablet that contains the non-steroidal anti-inflammatory drug (NSAID) diclofenac. It belongs to the class of propionic-acid NSAIDs and is formulated to deliver 100 mg of diclofenac over an extended period, allowing once-daily dosing for chronic inflammatory conditions. The medication is manufactured by a pharmaceutical company that distributes the product in several countries under the Voveran brand. In addition to its approved uses for musculoskeletal pain and arthritis, diclofenac has been investigated for several off-label applications, which are discussed later in this article.

What is Voveran SR?

• Definition: Voveran SR is a brand-name, sustained-release tablet that provides the active ingredient diclofenac potassium (or sodium) at a strength of 100 mg per tablet.
• Classification: It is an NSAID of the propionic-acid class, chemically related to ibuprofen and naproxen but with a higher potency for cyclooxygenase (COX) inhibition.
• Development history: Diclofenac was first synthesized in the s and quickly became a widely used anti-inflammatory agent. Extended-release formulations such as Voveran SR were later developed to improve patient adherence by reducing dosing frequency.
• Manufacturer: The specific manufacturer of Voveran SR varies by market; in many regions the product is produced by a licensed pharmaceutical firm that partners with local distributors.

Voveran SR is the generic version of well-known medications, containing the active compound diclofenac. Our online pharmacy provides this generic alternative as a cost-effective treatment option.

How Voveran SR Works

Diclofenac exerts its therapeutic effect primarily by inhibiting cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzymes. These enzymes convert arachidonic acid into prostaglandins, which are lipid mediators that promote inflammation, pain, and fever. By blocking COX activity, diclofenac reduces prostaglandin synthesis at sites of injury or inflammation, leading to:

1. Decreased inflammatory swelling - less vascular permeability and leukocyte infiltration.
2. Reduced pain signaling - fewer prostaglandin-sensitized nociceptors.
3. Lowered fever - diminished hypothalamic prostaglandin E₂.

The sustained-release matrix of Voveran SR slowly dissolves in the gastrointestinal tract, producing a steady plasma concentration that typically peaks within 6-8 hours and remains therapeutic for 24 hours. The drug is extensively metabolized in the liver (primarily by CYP2C9) and eliminated mainly via renal excretion.

Conditions Treated with Voveran SR

Approved indications (as per FDA/EMA labeling)

• Osteoarthritis - alleviates joint pain and improves functional mobility.
• Rheumatoid arthritis - reduces synovial inflammation and joint tenderness.
• Ankylosing spondylitis - mitigates spinal stiffness and inflammatory back pain.
• Chronic musculoskeletal pain - such as low-back pain, tendonitis, and bursitis.
• Post-operative pain - after minor surgical procedures where NSAID therapy is appropriate.

Why diclofenac is effective: In these conditions, inflammation is driven by excess prostaglandin production. Diclofenac’s potent COX inhibition curtails this cascade, providing analgesic and anti-inflammatory benefits that translate into better joint function and quality of life.

Off-Label and Investigational Uses of Voveran SR

While regulatory agencies have not approved the following uses, peer-reviewed studies and clinical guidelines have explored them:

1. Migraine prophylaxis - Small randomized trials suggest that low-dose diclofenac may reduce migraine frequency, likely through its anti-inflammatory properties.
2. Dysmenorrhea (menstrual pain) - Clinical observations indicate that diclofenac can be as effective as other NSAIDs for primary dysmenorrhea.
3. Cancer-related bone pain - Some oncologic pain protocols incorporate diclofenac as an adjunct to opioid therapy, though evidence remains limited.
4. Gout flares - NSAIDs are a mainstay of acute gout management; diclofenac has been used off-label for this purpose.

Important: Off-label use of Voveran SR should only be undertaken under the direct supervision of a qualified healthcare professional. Efficacy and safety for these indications have not been formally evaluated by regulatory bodies.

Is Voveran SR the Right Medication for You?

• Ideal candidates are adults requiring continuous anti-inflammatory therapy for chronic joint disorders (e.g., osteoarthritis, rheumatoid arthritis) who prefer once-daily dosing.
• Clinical scenarios favoring Voveran SR include patients with a history of poor adherence to multiple daily doses, or those who have responded well to diclofenac but need a more convenient regimen.
• Contraindications (see detailed list later) encompass: active gastrointestinal ulceration, severe heart failure, known hypersensitivity to diclofenac or other NSAIDs, and the third trimester of pregnancy.

Patients with renal impairment, uncontrolled hypertension, or a history of cardiovascular events should be evaluated carefully before initiating therapy.

Risks, Side Effects, and Interactions

Common

• Gastro-intestinal discomfort (epigastric pain, dyspepsia)
• Headache
• Dizziness
• Peripheral edema

These effects typically appear early in treatment and may be mitigated by taking the tablet with food or a full glass of water.

Rare

• Elevated liver enzymes (transaminases) indicating hepatic stress
• Photosensitivity reactions (skin rash on sun exposure)
• Thrombocytopenia (reduced platelet count)

Routine laboratory monitoring is advisable for patients on long-term therapy.

Serious

• Gastro-intestinal bleeding, perforation, or ulcer - risk increases with concomitant corticosteroids, anticoagulants, or a history of ulcer disease.
• Cardiovascular events (myocardial infarction, stroke) - diclofenac carries a class-wide warning for increased risk, especially in patients with existing cardiovascular disease.
• Severe hypersensitivity (anaphylaxis, Stevens-Johnson syndrome) - immediate medical attention required.
• Renal failure - particularly in elderly patients, those with pre-existing kidney disease, or volume depletion.

Drug-drug interactions

• Anticoagulants (warfarin, DOACs) - increased bleeding risk.
• Other NSAIDs or COX-2 inhibitors - additive gastrointestinal toxicity.
• ACE inhibitors/ARBs - may worsen renal function.
• Lithium - NSAIDs can raise serum lithium levels, risking toxicity.

Drug-food interactions

• Alcohol - synergistic irritation of the gastric mucosa; avoid excessive consumption.
• High-salt meals - may exacerbate fluid retention in susceptible individuals.

Patients should always inform their healthcare provider of all medications, supplements, and dietary habits before starting Voveran SR.

Use: Dosing, Missed Dose, Overdose

• Standard dosing: One tablet (100 mg) of Voveran SR taken orally once daily, preferably with the evening meal to reduce gastrointestinal irritation.
• Renal or hepatic impairment: Dose reduction to 50 mg once daily may be considered under medical guidance.
• Missed dose: If a dose is forgotten and more than 12 hours have elapsed, skip the missed tablet and resume the regular schedule the next day. Do not double-dose.
• Overdose: Symptoms may include nausea, vomiting, abdominal pain, dizziness, and possibly seizures. Immediate medical attention is essential; activated charcoal may be used if presentation is within one hour of ingestion.

Practical precautions

• Swallow the tablet whole; do not crush or chew, as this destroys the sustained-release matrix.
• Avoid concurrent use of alcohol or other NSAIDs.
• Do not operate heavy machinery or drive until you know how Voveran SR affects you, especially during the first few days of therapy.

FAQ

• What should I store Voveran SR tablets in? Store the tablets in a dry place at room temperature (15-30 °C). Protect them from excessive heat, moisture, and direct sunlight.

• Can I travel internationally with Voveran SR? Yes, but keep the medication in its original packaging with the label intact. Check the destination country’s regulations on importing NSAIDs, as some require a prescription or have quantity limits.

• What do the tablets look like? Voveran SR tablets are typically coated, round, and imprinted with “V-100” or a similar identifier. Inactive ingredients may include lactose, magnesium stearate, and microcrystalline cellulose.

• Is Voveran SR safe for vegetarians or vegans? The formulation contains lactose, so it is not suitable for strict vegans. Patients with lactose intolerance may experience mild gastrointestinal symptoms; an alternative formulation without lactose should be discussed with a clinician.

• Will Voveran SR show up on drug tests? Standard workplace drug screens do not target NSAIDs, so Voveran SR will not produce a positive result for common illicit-drug panels.

• How long does it take for pain relief to begin? Onset of analgesia generally occurs within 30-60 minutes, with peak effect around 4-6 hours. The sustained-release design maintains therapeutic levels for up to 24 hours.

• Can I take Voveran SR with antihypertensive medication? Yes, but caution is advised. NSAIDs can blunt the blood-pressure-lowering effect of certain antihypertensives (e.g., ACE inhibitors, diuretics). Blood pressure should be monitored regularly.

• Is it necessary to take a proton-pump inhibitor (PPI) with Voveran SR? Patients at high risk for gastrointestinal ulceration (history of ulcer, age > 65, concurrent steroids) may benefit from a prescribed PPI to protect the gastric lining.

• What is the difference between Voveran SR and immediate-release diclofenac? Voveran SR provides a single 100 mg dose that releases the drug gradually over 24 hours, reducing dosing frequency and peak-plasma concentrations. Immediate-release forms are taken multiple times per day and generate higher peak levels, which may increase the risk of gastrointestinal side effects.

• Can I use Voveran SR while breastfeeding? Diclofenac is excreted in breast milk in small amounts. Although short-term use is generally considered compatible with breastfeeding, prolonged therapy should be discussed with a pediatrician or lactation consultant.

Glossary

Cyclooxygenase (COX)

An enzyme that converts arachidonic acid into prostaglandins; COX-1 is constitutive, while COX-2 is inducible during inflammation.

Sustained-release (SR)

A dosage form designed to release the active ingredient slowly over an extended period, providing prolonged therapeutic effect and reducing dosing frequency.

Prostaglandin

Lipid compounds that act locally to mediate inflammation, pain, fever, and other physiological responses.

Pharmacokinetics

The study of how a drug is absorbed, distributed, metabolized, and eliminated by the body.

Buying Voveran SR from Our Online pharmacy

Patients who encounter limited availability of diclofenac-based therapies, face high out-of-pocket costs, or prefer a discreet purchasing channel can obtain Voveran SR through our online pharmacy.

• Affordable pricing: We source Voveran SR directly from licensed manufacturers, allowing us to offer prices that closely reflect the product’s manufacturing cost, often substantially lower than retail pharmacy rates.
• Verified quality: Every batch is verified for authenticity and potency by accredited quality-control laboratories before it leaves the supplier’s warehouse.
• Guaranteed delivery: Orders are packaged discreetly and shipped using reliable carriers; express delivery typically arrives within 7 days, while standard airmail takes approximately 3 weeks.
• Global access: Our pharmacy broker service partners with overseas licensed pharmacies, enabling patients in regions with restricted medication access to obtain legally compliant, genuine Voveran SR.

By choosing our online pharmacy, you gain a trusted, cost-effective pathway to the medication you need while maintaining privacy and convenience.

Disclaimer

The information presented about Voveran SR is intended for general educational purposes only and does not substitute professional medical advice. Treatment choices, including any off-label applications, must be made under the guidance of a qualified healthcare provider. Readers are assumed to be responsible adults capable of making informed health decisions. Our online pharmacy supplies Voveran SR for individuals who may encounter limited access through conventional pharmacies or who are seeking an affordable generic alternative. Always discuss with your clinician before initiating, altering, or discontinuing any medication.