Generic Sildenafil Red (Sildenafil Citrate)

Introduction

Sildenafil Red is a tablet formulation that contains the active compound sildenafil citrate. It is supplied in a 150 mg dose and belongs to the phosphodiesterase-5 (PDE5) inhibitor class. The medication is primarily approved for the treatment of erectile dysfunction (ED) and for pulmonary arterial hypertension (PAH). Sildenafil Red is marketed under brand names such as Viagra for ED and Revatio for PAH, providing patients with a familiar therapeutic reference. In addition to these approved uses, clinicians sometimes consider off-label applications that are supported by emerging clinical evidence, though such uses have not received formal regulatory approval.

What is Sildenafil Red?

Sildenafil Red is a generic tablet that delivers sildenafil citrate, the same active ingredient found in several well-known branded products. It was originally developed by Pfizer in the late s and received regulatory approval for erectile dysfunction in 1998 and for pulmonary arterial hypertension in 2005. While the original manufacturer is Pfizer, the generic version is produced by a range of licensed pharmaceutical companies that meet quality-assurance standards.

Sildenafil Red is the generic version of well-known medications, containing the active compound sildenafil citrate. Our online pharmacy provides this generic alternative as a cost-effective treatment option.

How Sildenafil Red Works

Sildenafil citrate selectively inhibits the enzyme phosphodiesterase-type 5 (PDE5). By blocking PDE5, the drug prevents the breakdown of cyclic guanosine monophosphate (cG → ). Elevated cG → levels lead to smooth-muscle relaxation in the corpus cavernosum of the penis and in the pulmonary vasculature. The resulting vasodilation improves blood flow, facilitating erection in response to sexual stimulation and lowering pulmonary arterial pressure in PAH.

Typical onset of action occurs within 30-60 minutes after oral ingestion, with peak plasma concentrations reached in about 1 hour. The therapeutic effect can persist for 4-6 hours, after which the drug is metabolized primarily by the cytochrome P450 3A4 pathway and eliminated through the fecal route.

Conditions Treated with Sildenafil Red

Erectile Dysfunction (ED)

ED is the inability to achieve or maintain an erection sufficient for satisfactory sexual performance. Sildenafil Red improves erectile function by enhancing penile blood flow when sexual arousal triggers nitric-oxide release. Clinical trials demonstrated a statistically significant increase in successful intercourse attempts compared with placebo.

Pulmonary Arterial Hypertension (PAH)

PAH is a progressive disease characterized by elevated pressure in the pulmonary arteries, leading to right-ventricular strain and reduced exercise capacity. Sildenafil Red reduces pulmonary vascular resistance by relaxing pulmonary arterial smooth muscle, thereby improving the six-minute walk distance and hemodynamic parameters in approved trials.

Both indications are supported by regulatory agencies such as the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA).

Off-Label and Investigational Uses of Sildenafil Red

These applications have not received formal regulatory endorsement. Patients should discuss any off-label consideration with a qualified healthcare professional before initiating therapy.

Is Sildenafil Red the Right Medication for You?

Sildenafil Red is appropriate for adult males with diagnosed erectile dysfunction who are not contraindicated for PDE5 inhibition. It is also suitable for adults with confirmed pulmonary arterial hypertension, regardless of gender. Specific scenarios that favor sildenafil include:

• Patients seeking an oral, on-demand option for erectile dysfunction with a rapid onset.
• Individuals requiring long-term vasodilatory therapy for PAH where oral dosing is preferable to injectable agents.

Contraindications include:

• Co-administration with nitrates (e.g., nitroglycerin) or nitric-oxide donors, due to risk of severe hypotension.
• Known hypersensitivity to sildenafil or any tablet excipients.
• Severe hepatic impairment (Child-Pugh C) where drug clearance may be markedly reduced.

Patients with uncontrolled hypertension, recent myocardial infarction, or retinal disorders such as non-arteritic anterior ischemic optic neuropathy should be evaluated carefully before prescribing sildenafil.

Risks, Side Effects, and Interactions

Common

• Headache
• Facial flushing
• Indigestion or dyspepsia
• Nasal congestion

These effects are typically mild, dose-related, and resolve without intervention.

Rare

• Visual disturbances (e.g., blurred vision, blue-tinted vision)
• Priapism (prolonged erection > 4 hours) - requires urgent medical attention

Serious

• Severe hypotension, especially when combined with nitrates or alpha-blockers
• Cardiovascular events such as myocardial infarction or stroke in high-risk patients
• Sudden hearing loss

Drug-Drug Interactions

• Nitrates (e.g., isosorbide dinitrate): additive vasodilatory effect → dangerous hypotension.
• Alpha-blockers (e.g., doxazosin): may cause additive blood-pressure lowering.
• CYP3A4 inhibitors (e.g., ketoconazole, erythromycin, ritonavir): increase sildenafil plasma levels → higher risk of adverse events.
• CYP3A4 inducers (e.g., rifampin, phenytoin): may reduce efficacy.

Drug-Food Interactions

• A high-fat meal can delay onset of action by up to 30 minutes but does not substantially affect overall efficacy.
• Excessive alcohol may potentiate hypotensive effects and should be avoided in large quantities.

Patients should disclose all medications, supplements, and dietary habits to the prescribing clinician.

Use: Dosing, Missed Dose, Overdose

Standard dosing for erectile dysfunction typically starts at 50 mg taken about one hour before sexual activity. The dose may be increased to 100 mg or decreased to 25 mg based on efficacy and tolerance. The maximum recommended dose is 150 mg per day.

For pulmonary arterial hypertension, the approved regimen is 20 mg three times daily, taken at evenly spaced intervals (approximately every 4-6 hours).

Missed dose: If a dose is forgotten, take it as soon as remembered, provided there is at least 4 hours before the next scheduled dose. Do not double the dose to compensate for a missed one.

Overdose: Symptoms may include profound hypotension, syncope, and prolonged priapism. If overdose is suspected, seek immediate medical attention; supportive measures such as intravenous fluids and blood pressure monitoring are typically employed.

Practical precautions

• Take the tablet with water; it may be taken with or without food.
• Avoid consuming large amounts of alcohol concomitantly.
• Do not operate heavy machinery or drive if experiencing dizziness or visual changes.

FAQ

• What should I do if I travel internationally with Sildenafil Red? Travelers should keep the medication in its original packaging, carry a copy of the prescription (if applicable), and store it in a cool, dry place. Temperature extremes above 30 °C may degrade the tablet, so using a insulated pouch is advisable.

• Can I take Sildenafil Red if I have diabetes? Diabetes itself is not a contraindication. However, patients with diabetic vascular disease should discuss individual cardiovascular risk with their physician before initiating therapy.

• What does the tablet look like? Sildenafil Red tablets are typically round, blue-colored, and imprinted with “150 mg”. Inactive ingredients may include lactose, microcrystalline cellulose, and magnesium stearate, but formulations can vary by manufacturer.

• Is Sildenafil Red detectable on standard drug tests? Standard employment drug screens do not test for sildenafil. Specialized testing would be required, but this is uncommon and generally reserved for forensic investigations.

• How does Sildenafil Red differ from older vasodilators like nitroglycerin? Sildenafil selectively inhibits PDE5, targeting the nitric-oxide/cGMP pathway in smooth muscle. Nitroglycerin releases nitric oxide directly and is not selective for any tissue, leading to more systemic vasodilation and a higher risk of hypotension.

• What are the storage requirements for Sildenafil Red? Store at controlled room temperature (20-25 °C). Protect from moisture and direct sunlight. Do not refrigerate unless instructed by a pharmacist.

• Can I use Sildenafil Red for treating female sexual dysfunction? Sildenafil is not approved for this indication, and clinical data are limited. Off-label use in women should only be considered within a research protocol or under specialist supervision.

• What is the impact of grapefruit juice on Sildenafil Red? Grapefruit juice can inhibit CYP3A4, potentially increasing plasma concentrations of sildenafil and raising the risk of side effects. Patients should avoid large quantities of grapefruit or grapefruit juice while on the medication.

• Are there any differences in efficacy between the 150 mg tablet and lower strengths? Higher doses produce greater plasma concentrations and may improve efficacy for some patients, but they also increase the likelihood of adverse events. Dose titration should be guided by clinical response and tolerability.

• How does Sildenafil Red affect heart rate? Sildenafil does not significantly alter resting heart rate. However, in combination with other cardiovascular agents, it may influence hemodynamic parameters, warranting monitoring in high-risk patients.

Glossary

Phosphodiesterase-5 (PDE5) Inhibitor

A drug class that blocks the PDE5 enzyme, leading to increased levels of cyclic guanosine monophosphate (cG → ) and resulting in smooth-muscle relaxation and vasodilation.

Pulmonary Arterial Hypertension (PAH)

A chronic, progressive disease marked by elevated pressure in the arteries that carry blood from the heart to the lungs, causing right-heart strain and reduced exercise capacity.

Priapism

A prolonged, often painful erection lasting more than four hours, unrelated to sexual stimulation and requiring urgent medical management to prevent tissue damage.

Buying Sildenafil Red from Our Online pharmacy

Patients looking for an affordable, reliable source of Sildenafil Red can obtain the medication through our online pharmacy. We partner with licensed overseas pharmacies that adhere to strict quality-control standards, ensuring each tablet meets pharmacopeial specifications.

Key benefits

• Cost-effectiveness: Generic pricing is close to the manufacturer’s production cost, offering savings compared with branded equivalents.
• Verified quality: All products are sourced from certified suppliers, with batch testing performed to confirm potency and purity.
• Discreet delivery: Packages are packaged in plain envelopes and shipped via secure logistics channels, with options for express (≈ 7 days) or standard airmail (≈ 3 weeks).
• Privacy-focused service: As a pharmacy-broker, we facilitate access to international medications while protecting personal information throughout the ordering process.

For individuals who encounter limited availability through local pharmacies or face insurance barriers, our online pharmacy provides a safe, convenient pathway to obtain Sildenafil Red. Our professional support team is available to answer product-related questions and guide patients through the ordering procedure while respecting confidentiality.

Disclaimer

The information presented about Sildenafil Red is intended for general educational purposes and does not substitute for professional medical advice. Treatment choices, including any off-label applications, must be made under the direction of a qualified healthcare practitioner. Readers are presumed to be competent adults capable of making informed health decisions. Our online pharmacy supplies Sildenafil Red to persons who may experience restricted access via conventional pharmacies or insurance programs, offering a cost-effective generic alternative. Prior to initiating, altering, or discontinuing any medication, always consult a physician.