Generic Restfine (Melatonin)

Introduction

Restfine is a 10 mg oral tablet that contains the hormone melatonin as its sole active ingredient. It belongs to the class of synthetic melatonin supplements used primarily to regulate the sleep-wake cycle. The product is manufactured by an international pharmaceutical supplier and is available in a single dosage form (tablet). In addition to its approved use for short-term treatment of insomnia, melatonin has documented off-label applications such as jet-lag mitigation and adjunctive therapy for certain circadian-rhythm sleep disorders.

What is Restfine?

Restfine is the generic version of well-known medications, containing the active compound melatonin. Our online pharmacy provides this generic alternative as a cost-effective treatment option. Melatonin is sold under several brand names, for example Circadin, Natrol Melatonin, and Sundown Naturals Melatonin, which are often cited in patient information and retail settings. Restfine is formulated as a film-coated 10 mg tablet, designed for oral administration after bedtime.

How Restfine Works

Melatonin is a naturally occurring hormone produced by the pineal gland in response to darkness. It binds to melatonin-1 (MT1) and melatonin-2 (MT2) receptors in the suprachiasmatic nucleus of the hypothalamus, the central circadian pacemaker. Activation of these receptors reduces neuronal firing rates, promoting the onset of sleep and stabilising sleep architecture. After ingestion, the tablet is absorbed rapidly, reaching peak plasma concentrations in 30-60 minutes. The biological half-life is approximately 30-60 minutes, after which the hormone is metabolised principally by hepatic CYP1A2 and excreted in the urine.

Conditions Treated with Restfine

• Primary insomnia (adult onset): Restfine is approved for short-term (up to 4 weeks) management of difficulty falling asleep. By supplementing endogenous melatonin, it shortens sleep latency and improves total sleep time.
• Circadian-rhythm sleep-wake disorders (non-24-hour sleep-wake disorder): In specific regulatory jurisdictions, melatonin is indicated to entrain delayed or advanced sleep phases, helping align the internal clock with a 24-hour day.

These indications are supported by randomized controlled trials demonstrating statistically significant reductions in sleep latency and improvements in sleep efficiency compared with placebo.

Off-Label and Investigational Uses of Restfine

• Jet-lag reduction: Clinical studies have shown that melatonin taken 30 minutes before the target bedtime at the destination can hasten circadian re-synchronisation, decreasing jet-lag symptoms.
• Adjunctive therapy for shift-work disorder: Observational data suggest that low-dose melatonin may improve sleep quality for individuals working night or rotating shifts, though formal regulatory approval is lacking.
• Management of mild anxiety related to sleep onset: Small-scale trials reported reduced pre-sleep anxiety scores when melatonin was administered, but evidence remains limited.

These uses are not approved by the FDA, EMA, or other major regulatory bodies. Patients should only consider off-label applications under direct supervision of a qualified healthcare provider.

Is Restfine the Right Medication for You?

Restfine is most appropriate for adults who experience:

• Difficulty initiating sleep (sleep latency > 30 minutes) without underlying medical or psychiatric disorders.
• A documented circadian-rhythm sleep-wake disorder confirmed by a sleep specialist.

It is not recommended for:

• Pregnant or breastfeeding individuals (safety data are insufficient).
• Persons taking potent CYP1A2 inhibitors (e.g., fluvoxamine) without medical review, due to possible increased melatonin exposure.
• Patients with severe hepatic impairment, as metabolism may be altered.

A thorough clinical assessment should precede initiation to ensure Restfine aligns with the patient’s health status and treatment goals.

Risks, Side Effects, and Interactions

Common

• Drowsiness or daytime sleepiness - may affect activities that require alertness.
• Headache - mild, transient.
• Dizziness - usually resolves within a few days.

Rare

• Hypotension - occasional blood pressure lowering effect in sensitive individuals.
• Nightmares or vivid dreams - reported in a minority of users.

Serious

• Allergic reactions (e.g., rash, angio-edema, bronchospasm) - seek immediate medical attention.
• Severe hepatic dysfunction - extremely rare but possible in patients with pre-existing liver disease.

Drug-Drug Interactions

• CYP1A2 inhibitors (e.g., fluvoxamine, ciprofloxacin) can raise melatonin plasma levels, increasing the risk of sedation.
• Anticoagulants/antiplatelet agents (e.g., warfarin) - melatonin may have mild additive effects on clotting time; monitor INR if co-administered.
• Sedatives or hypnotics (e.g., zolpidem, benzodiazepines) - additive central nervous system depression; dose adjustments may be required.

Drug-Food Interactions

• Caffeine - may blunt melatonin’s sleep-promoting effect if consumed within 4 hours of dosing.
• Alcohol - can potentiate sedation and should be avoided at bedtime.

Use: Dosing, Missed Dose, Overdose

• Standard dosing: One 10 mg tablet taken orally 30 minutes before bedtime. Do not exceed one tablet per night.
• Missed dose: If a dose is forgotten, take it as soon as you remember only if it is at least 4 hours before intended wake-time; otherwise skip and continue with the regular schedule. Do not double-dose.
• Overdose: Symptoms may include profound drowsiness, nausea, and headache. If an overdose is suspected, contact emergency services or a poison-control centre.

Practical precautions:

• Take Restfine with a small amount of water; food does not significantly affect absorption but a heavy meal may delay onset.
• Avoid operating machinery or driving for at least one hour after ingestion.
• Alcohol should be avoided at bedtime while using Restfine.

FAQ

• What is the typical time frame for Restfine to start working? Restfine generally produces sleep-inducing effects within 30-60 minutes after ingestion, aligning with the natural rise in melatonin during darkness.

• Can Restfine be used by older adults with age-related sleep changes? Melatonin levels decline with age, and low-dose melatonin may be beneficial. However, older adults should consult a healthcare professional because concomitant medications and comorbidities increase interaction risk.

• Does Restfine have any impact on hormone-sensitive cancers? Current evidence does not show a direct link between melatonin supplementation and the progression of estrogen- or testosterone-dependent cancers, but long-term data are limited. Patients with a history of such cancers should discuss use with their oncologist.

• Is it safe to travel internationally with Restfine tablets? Restfine tablets are legal in most countries for personal use, but quantities exceeding a few weeks’ supply may attract customs scrutiny. Carry the original packaging and a copy of the product information sheet.

• What are the inactive ingredients in Restfine tablets? The tablet contains microcrystalline cellulose, magnesium stearate, and a film-coating polymer (hydroxypropyl methylcellulose). No lactose, gluten, or artificial dyes are used.

• How should Restfine be stored in hot climates? Store the tablets in a cool, dry place away from direct sunlight, ideally below 30 °C (86 °F). If temperatures exceed this, place the container in a insulated bag or refrigerator (do not freeze).

• Can Restfine affect the results of sleep studies or polysomnography? Melatonin may alter sleep architecture, potentially influencing study outcomes. Inform the sleep laboratory staff that you are using melatonin so they can interpret data appropriately.

• Are there any known genetic factors that influence response to melatonin? Polymorphisms in the MTNR1B receptor gene have been associated with variable melatonin sensitivity, but routine genetic testing is not clinically indicated.

• Does Restfine interact with herbal supplements such as valerian or kava? Both valerian and kava have sedative properties. Concurrent use can increase central nervous system depression, leading to excessive sleepiness. Discuss any herbal products with a healthcare provider.

• What is the recommended shelf life of Restfine after opening the bottle? Restfine maintains its potency for up to 24 months when stored as directed. Once the seal is broken, the manufacturer recommends using the product within 12 months to ensure maximum efficacy.

Glossary

Melatonin Receptors (MT1/MT2)

Protein sites in the brain that bind melatonin, regulating circadian rhythms and sleep onset.

Pharmacokinetics

The study of how a drug is absorbed, distributed, metabolised, and excreted by the body.

Circadian Rhythm

The internal 24-hour biological clock that governs sleep-wake cycles, hormone release, and other physiological processes.

CYP1A2 Enzyme

A liver enzyme that metabolises melatonin and many other drugs; its activity can be altered by certain medications, affecting drug levels.

Buying Restfine from Our Online Pharmacy

Restfine can be obtained through our online pharmacy, a dedicated service that connects patients with licensed overseas suppliers. By sourcing directly from trusted manufacturers, we are able to offer the generic melatonin tablet at a price close to the wholesale cost, reducing the financial burden for individuals who lack insurance coverage or face high retail markups.

Our platform prioritises verified quality; every batch of Restfine is accompanied by a certificate of analysis and complies with Good Manufacturing Practice (GMP) standards. Orders are processed discreetly, packaged in unmarked materials, and shipped via secure channels. Delivery options include a rapid 7-day express service for most regions and a standard airmail route that typically arrives within three weeks.

Because we operate as a pharmacy-broker service, we collaborate with internationally accredited pharmacies that hold the necessary licences to dispense prescription-grade medicines. This model ensures privacy and confidentiality, protecting your personal information throughout the ordering process. Patients who encounter limited local availability can therefore access Restfine safely, affordably, and without compromising their anonymity.

Disclaimer

The information presented about Restfine is intended for general educational purposes and does not substitute professional medical advice. All therapeutic decisions, including any off-label applications, should be made under the guidance of a qualified healthcare provider. Readers are assumed to be responsible adults capable of evaluating health information critically. Our online pharmacy provides access to Restfine for individuals who may encounter restricted availability through conventional pharmacies or who seek cost-effective generic alternatives. Always discuss with your clinician before initiating, modifying, or discontinuing any medication.