Meloset (Melatonin)

Introduction

Meloset is a 3 mg oral tablet that contains the hormone melatonin as its sole active ingredient. It belongs to the class of melatonin receptor agonists, which are used to regulate the sleep-wake cycle. The product is manufactured as a generic alternative to several well-known brand-name melatonin preparations, such as Circadin and Melatonin (available in various markets). Meloset is primarily indicated for the short-term treatment of insomnia characterized by difficulty falling asleep. In some regions it is also approved for the management of jet-lag-related sleep disturbances. Off-label, clinicians sometimes consider melatonin for shift-work disorder, delayed sleep-phase syndrome, and certain neuropsychiatric conditions, but these uses have not received formal regulatory endorsement.

What is Meloset?

Meloset is the generic version of well-known medications, containing the active compound Melatonin. Our online pharmacy provides this generic alternative as a cost-effective treatment option. Melatonin is a naturally occurring indoleamine produced by the pineal gland, and it plays a central role in synchronising circadian rhythms. The tablet formulation of Meloset is designed for rapid oral absorption, delivering a fixed 3 mg dose. The product is marketed by a licensed pharmaceutical company (manufacturer details vary by country) and complies with the quality standards required for over-the-counter sleep aids in jurisdictions where melatonin is regulated as a medicinal product.

How Meloset Works

Melatonin exerts its effect by binding to MT1 and MT2 receptors located in the suprachiasmatic nucleus of the hypothalamus, the master clock that governs circadian timing. Activation of these G-protein-coupled receptors reduces neuronal firing rates, signalling to the body that night has arrived. This biochemical cue promotes the onset of sleep, shortens sleep latency, and can modestly improve sleep continuity.

After oral ingestion, melatonin is absorbed within 30-60 minutes, reaching peak plasma concentrations (C_max) at approximately 45 minutes. The drug’s elimination half-life ranges from 30 to 60 minutes, reflecting rapid hepatic metabolism primarily via CYP1A2. Because the pharmacokinetic profile is short, the sleep-promoting effect is largely confined to the early part of the night, minimizing residual daytime sedation when taken at the recommended time.

Conditions Treated with Meloset

• Primary insomnia (difficulty falling asleep) - Clinical trials in adults have demonstrated that a single 3 mg dose taken 30 minutes before bedtime reduces sleep onset latency by an average of 7-10 minutes compared with placebo.
• Jet lag - When administered at the target bedtime in the new time zone, melatonin helps re-align the internal clock, shortening the duration of jet-lag symptoms such as daytime sleepiness and nighttime wakefulness.

These indications are supported by regulatory approvals in the European Union and several other jurisdictions where melatonin is classified as a prescription or pharmacist-dispensed medication.

Off-Label and Investigational Uses of Meloset

• Shift-work disorder - Small randomized studies suggest that melatonin taken before daytime sleep can improve total sleep time for night-shift workers. The evidence is modest, and the indication is not approved by the FDA or EMA.
• Delayed sleep-phase disorder (DSPD) - Chronotherapy protocols often incorporate melatonin taken several hours before the desired bedtime to advance circadian phase. Clinical guidelines acknowledge melatonin as a useful adjunct, but formal approval is lacking.
• Adjunctive treatment for anxiety - Some pilot trials have reported reduced pre-sleep anxiety scores when melatonin is combined with cognitive-behavioral therapy for insomnia. This use remains investigational.
• Neurodegenerative disease support - Observational data in Parkinson’s and Alzheimer’s disease populations indicate that melatonin may improve sleep quality and possibly exert antioxidant effects, yet randomized controlled evidence is insufficient for regulatory endorsement.

Important: Off-label applications should only be pursued under the direct supervision of a qualified healthcare provider. The safety and efficacy of melatonin for these conditions have not been formally validated by regulatory agencies.

Is Meloset the Right Medication for You?

Meloset is most appropriate for adults who experience:

• Difficulty initiating sleep (sleep latency > 30 minutes) on a regular basis.
• Transient sleep disturbances related to travel across time zones.

It is less suitable for individuals with:

• Chronic insomnia that persists despite behavioral interventions.
• Uncontrolled psychiatric disorders, severe depression, or active suicidal ideation.
• Known hypersensitivity to melatonin or any excipients in the tablet.

Patients with hepatic impairment may experience higher plasma concentrations and should discuss dose adjustments with a clinician. Pregnant or breastfeeding women should only use melatonin if the potential benefit outweighs the uncertain risk.

Risks, Side Effects, and Interactions

Common

• Drowsiness or morning grogginess (especially if taken too late).
• Headache.
• Dizziness.
• Mild gastrointestinal discomfort (nausea, abdominal cramps).

Rare

• Vivid or unpleasant dreams.
• Mood changes such as irritability or mild depression.
• Transient increase in blood pressure in susceptible individuals.

Serious

• Allergic reactions (rash, pruritus, angioedema, anaphylaxis).
• Severe depression or suicidal thoughts (rare, reported in case series).
• Seizure exacerbation in patients with epilepsy (isolated reports).

Drug-Drug Interactions

• CNS depressants (e.g., benzodiazepines, antihistamines) - additive sedation.
• Anticoagulants (warfarin, direct oral anticoagulants) - melatonin may potentiate anticoagulant effect; monitor INR or bleeding risk.
• Immunosuppressants (e.g., cyclosporine) - possible reduction in drug efficacy.
• Oral contraceptives - melatonin can increase plasma concentrations of estrogen, potentially raising the risk of thromboembolic events.

Drug-Food Interactions

• Caffeine - may blunt melatonin’s sleep-inducing effect if consumed within 4 hours of dosing.
• Alcohol - synergistic central nervous system depression; avoid concurrent use.

Patients should inform their pharmacist of all concurrent medications, supplements, and herbal products.

Use: Dosing, Missed Dose, Overdose

• Standard dose: One 3 mg tablet taken orally 30-60 minutes before the intended bedtime.
• Maximum recommended frequency: Once daily; do not exceed the prescribed dose without professional guidance.

Missed dose: If a dose is forgotten, skip it and resume the regular schedule the following night. Taking a double dose to “make up” for a missed tablet is not advised because it may increase the risk of next-day drowsiness.

Overdose: Acute ingestion of several tablets may cause pronounced sedation, hypotension, and gastrointestinal upset. Management is supportive: monitor vital signs, ensure airway protection, and seek medical attention if severe symptoms develop. No specific antidote exists.

Practical precautions:

• Avoid taking Meloset with a heavy meal; a light snack is acceptable.
• Refrain from operating machinery or driving until the full sedative effect has worn off.
• Alcohol should be avoided on the night of dosing.

FAQ

• What does a Meloset tablet look like?   Meloset tablets are round, white, and imprinted with “M3” on one side. The tablet contains melatonin as the active ingredient and standard excipients such as microcrystalline cellulose, lactose, and magnesium stearate.

• Can I travel internationally with Meloset?   Yes. Carry the medication in its original packaging with a copy of the product label. Some countries restrict the import of melatonin, so verify local regulations before departure.

• How should I store Meloset?   Store the tablets at room temperature (15-30 °C) away from excess heat, moisture, and direct sunlight. Do not refrigerate or freeze.

• Is melatonin safe for people with diabetes?   Current evidence does not show a clinically significant impact on blood glucose. However, patients on insulin or oral hypoglycemics should monitor their levels, as any change in sleep patterns can indirectly affect glycemic control.

• Does Meloset interact with hormonal birth control?   Melatonin may modestly increase estrogen levels, potentially raising the risk of clotting when combined with combined oral contraceptives. Discuss any concerns with a healthcare professional.

• Will taking Meloset affect my blood test results?   Melatonin does not typically interfere with routine laboratory assays. However, it may influence hormone panels that measure endogenous melatonin or cortisol rhythms if samples are collected at night.

• What is the difference between immediate-release and extended-release melatonin?   Immediate-release formulations (such as Meloset) reach peak plasma levels quickly and are best for sleep-onset problems. Extended-release products maintain elevated melatonin concentrations throughout the night, targeting sleep-maintenance insomnia.

• Can I take Meloset with caffeine?   Caffeine can diminish melatonin’s effectiveness if consumed within a few hours of dosing. For optimal results, limit caffeine intake after midday on the night you plan to use Meloset.

• How long does melatonin stay in the body?   The elimination half-life of melatonin is roughly 30-60 minutes, so most of the dose is cleared within 4-5 hours. Residual effects are usually minimal after a full night’s sleep.

• Is melatonin considered a hormone supplement?   Yes. Melatonin is an endogenous hormone that regulates circadian rhythms. Supplemental melatonin mimics the natural hormone’s action but is administered pharmacologically.

Glossary

Circadian Rhythm

The roughly 24-hour internal clock that governs physiological processes such as sleep-wake cycles, hormone secretion, and body temperature.

Pharmacokinetics

The study of how a drug is absorbed, distributed, metabolized, and eliminated by the body.

Melatonin Receptor Agonist

A compound that binds to and activates melatonin (MT1/MT2) receptors, producing effects similar to the natural hormone.

Half-Life

The time required for the plasma concentration of a drug to decrease by 50 %. For melatonin, this is typically 30-60 minutes.

Buying Meloset from Our Online Pharmacy

Patients who encounter limited availability or high out-of-pocket costs for melatonin can obtain Meloset through our online pharmacy. We source the medication exclusively from licensed, internationally accredited manufacturers, ensuring that each batch meets stringent quality standards. Because we operate as a pharmacy-broker service, we can offer the generic product at a price close to the manufacturer’s cost, providing a financially sustainable alternative to brand-name options.

Our fulfillment process includes discreet packaging, secure payment handling, and reliable shipping. Standard delivery typically arrives within 7 days via express courier, while regular airmail may take up to three weeks, depending on the destination. Privacy is a core priority; all orders are shipped in unmarked envelopes, and personal data is protected in compliance with applicable data-protection regulations.

By choosing our online pharmacy, patients gain a trustworthy, cost-effective pathway to access Meloset when conventional pharmacy channels are unavailable or prohibitively expensive.

Disclaimer

The information presented about Meloset is intended for general educational purposes and does not substitute professional medical advice. Treatment choices, including any off-label applications, should be made under the direct supervision of a qualified healthcare provider. Readers are presumed to be responsible adults capable of making informed health decisions. Our online pharmacy supplies Meloset to individuals who may face limited access through conventional pharmacies or who seek affordable generic alternatives. Always consult a qualified practitioner before initiating, modifying, or discontinuing any medication.