Vigora (Sildenafil Citrate)

Introduction

Vigora is a phosphodiesterase-type-5 (PDE5) inhibitor whose active ingredient is Sildenafil Citrate. It is supplied as a 100 mg oral tablet and is approved for the treatment of erectile dysfunction (ED) in adult men and for pulmonary arterial hypertension (PAH) when used at the appropriate dosing schedule. The medication belongs to the class of drugs that enhance nitric-oxide-mediated blood flow in selected vascular beds. In addition to its primary indications, clinical investigations have explored several off-label applications, although these uses have not received regulatory approval.

What is Vigora?

Vigora is a tablet formulation that contains 100 mg of Sildenafil Citrate, a synthetic analogue of the naturally occurring molecule that modulates smooth-muscle tone. It is classified as a PDE5 inhibitor and is produced by a licensed pharmaceutical manufacturer that complies with Good Manufacturing Practice (GMP) standards.

Vigora is the generic version of well-known medications, containing the active compound Sildenafil Citrate. Our online pharmacy provides this generic alternative as a cost-effective treatment option. The drug is marketed under brand names such as Viagra and Revatio, which are widely recognized in the United States and Europe.

How Vigora Works

Sildenafil Citrate selectively blocks the enzyme phosphodiesterase-type-5. Under normal physiology, nitric oxide released from endothelial cells stimulates the production of cyclic guanosine monophosphate (cGMP). cGMP relaxes smooth muscle and dilates blood vessels, particularly in the corpus cavernosum of the penis and in the pulmonary arterial circulation.

By inhibiting PDE5, Vigora prevents the breakdown of cGMP, thereby prolonging its vasodilatory effect. The result is increased blood inflow to the erectile tissue during sexual stimulation and reduced vascular resistance in the lungs of patients with PAH. Onset of action typically occurs within 30-60 minutes after ingestion, with a therapeutic window lasting up to 4-6 hours. The drug is metabolised primarily by hepatic CYP3A4 enzymes and eliminated in the urine as inactive metabolites.

Conditions Treated with Vigora

• Erectile Dysfunction (ED). In men with inadequate nocturnal or psychogenic erections, the enhanced cGMP response facilitates erection sufficient for sexual activity. Clinical trials demonstrated significant improvement in the International Index of Erectile Function (IIEF) scores compared with placebo.

• Pulmonary Arterial Hypertension (PAH). In the low-dose regimen (20 mg three times daily), Vigora reduces pulmonary vascular resistance, improves exercise capacity (6-minute walk distance), and delays disease progression. This indication mirrors the use of the same molecule under the brand name Revatio.

The drug’s efficacy in these conditions stems from its ability to selectively augment nitric-oxide signalling in targeted vascular territories while preserving systemic blood pressure in most patients.

Off-Label and Investigational Uses of Vigora

• Raynaud’s Phenomenon. Small clinical series have reported that Sildenafil improves digital blood flow and reduces frequency of vasospastic attacks, although larger trials are lacking.

• High-Altitude Pulmonary Edema (HAPE). Preliminary studies suggest that PDE5 inhibition may counteract hypoxia-induced pulmonary hypertension, but routine use is not endorsed by regulatory agencies.

• Benign Prostatic Hyperplasia (BPH) with Lower-Urinary-Tract Symptoms. A few randomized controlled trials observed modest improvement in urinary flow rates, likely due to smooth-muscle relaxation in the prostate and bladder neck.

• Sickle Cell Disease-Related Pulmonary Hypertension. Early phase research indicates potential benefit, but safety data remain limited.

All of the above applications are not officially approved by the FDA, EMA, or other major health authorities. Use for these purposes should only occur under the direct supervision of a qualified healthcare provider, after a thorough risk-benefit assessment.

Is Vigora the Right Medication for You?

Vigora is most appropriate for adult males who experience consistent difficulty achieving or maintaining an erection sufficient for satisfactory sexual activity, provided they have no contraindicating cardiovascular conditions. It is also indicated for patients diagnosed with PAH who require long-term hemodynamic improvement.

Patients who are currently using organic nitrates (e.g., nitroglycerin), have severe uncontrolled hypertension, recent myocardial infarction or stroke, or have a known hypersensitivity to Sildenafil should avoid Vigora. Additionally, individuals with certain hereditary retinal disorders (e.g., retinitis pigmentosa) are advised against its use due to potential visual adverse events.

Risks, Side Effects, and Interactions

Common

• Headache
• Facial flushing
• Dyspepsia or indigestion
• Nasal congestion
• Visual disturbances (e.g., blue-tinted vision, increased sensitivity to light)

These effects are usually mild, transient, and resolve without medical intervention.

Rare

• Priapism (prolonged erection lasting > 4 hours)
• Sudden hearing loss or tinnitus
• Cutaneous rash or pruritus
• Gastrointestinal ulceration (very infrequent)

Patients experiencing any of these should seek prompt evaluation.

Serious

• Severe hypotension, especially when combined with nitrates or potent vasodilators
• Non-arteritic anterior ischemic optic neuropathy (NAION) leading to sudden vision loss
• Myocardial infarction or stroke in high-risk individuals
• Life-threatening allergic reactions (anaphylaxis)

These events require immediate emergency care.

Drug-Drug and Drug-Food Interactions

• Nitrates (e.g., nitroglycerin, isosorbide mononitrate): risk of profound hypotension.
• Alpha-blockers (e.g., tamsulosin, doxazosin): may cause additive blood-pressure lowering effects.
• CYP3A4 inhibitors (ketoconazole, itraconazole, ritonavir): increase plasma Sildenafil levels, raising toxicity risk.
• CYP3A4 inducers (rifampin, carbamazepine, St. John’s wort): reduce efficacy by lowering drug concentrations.
• Recreational vasodilators (“poppers” - amyl nitrate): should be avoided due to synergistic hypotensive risk.
• High-fat meals: can delay absorption, reducing peak concentration and delaying onset of action.

Use: Dosing, Missed Dose, Overdose

• Standard dosing for ED: Start with 50 mg taken about 1 hour before anticipated sexual activity. Depending on effectiveness and tolerability, the dose may be increased to 100 mg or decreased to 25 mg. Do not exceed one tablet per day.
• Standard dosing for PAH: 20 mg taken orally three times daily, spaced evenly (approximately every 8 hours).

Missed dose: If a dose is forgotten and the intended sexual activity is still more than 4 hours away, take the tablet at the next appropriate time. Do not double the dose to compensate for a missed tablet.

Overdose: Symptoms may include severe hypotension, dizziness, prolonged erection, or visual changes. If overdose is suspected, seek emergency medical attention promptly. Monitoring of blood pressure and cardiac status is recommended.

Precautions:

• Limit alcohol consumption, as it can exacerbate hypotension and dizziness.
• Avoid operating heavy machinery or driving if you feel light-headed.
• The medication can be taken with or without food, but a high-fat meal may delay onset.

FAQ

• Can Vigora be taken with antihypertensive medications? Sildenafil may modestly lower blood pressure, but it is generally safe with most antihypertensive agents when used at recommended doses. However, concurrent use with nitrate-based drugs is contraindicated because of the risk of severe hypotension.

• What should I do if I experience a painful erection lasting more than four hours? A prolonged erection (priapism) is a medical emergency. Seek immediate care; treatment may involve intracavernosal injection of sympathomimetic agents or surgical intervention to prevent tissue damage.

• Does Vigora interact with herbal supplements such as ginkgo biloba? Ginkgo biloba possesses mild antiplatelet activity and has been reported to potentiate the effects of Sildenafil on blood pressure. While a serious interaction is uncommon, discuss any supplement use with your healthcare provider before starting Vigora.

• How long does Vigora stay detectable in urine drug tests? Sildenafil can be detected in urine for up to 48 hours after a single dose, depending on the sensitivity of the assay. Chronic users may have a longer detection window.

• Is it safe to travel internationally with Vigora tablets? Yes, provided the medication is kept in its original packaging, labeled with the prescription information (if required), and stored at room temperature. Check the destination country’s import regulations for personal medication before departure.

• What is the appearance of a Vigora tablet? Each Vigora tablet is round, white to off-white, and bears the imprint “VIG-100 mg” on one side. The tablet is film-coated to aid swallowing.

• Are there any specific storage conditions for Vigora? Store the tablets in a dry place at temperatures between 15 °C and 30 °C (59 °F-86 °F). Protect them from excess moisture and direct sunlight, as degradation may occur under extreme conditions.

• Can Vigora be used by women for sexual dysfunction? Sildenafil has been studied in female sexual arousal disorder, but it is not approved for this indication, and efficacy data remain inconclusive. Women should consult a qualified healthcare professional before considering off-label use.

• Will alcohol consumption affect the effectiveness of Vigora? Alcohol can impair the ability to achieve an erection and may increase the risk of hypotension when combined with Sildenafil. Moderate alcohol intake is generally tolerated, but excessive drinking is discouraged.

• Is it necessary to take Vigora on an empty stomach? Vigora can be taken with or without food. However, a high-fat meal may delay the drug’s absorption, reducing the speed of onset. For predictable timing, many patients prefer taking it after a light meal or on an empty stomach.

Glossary

Phosphodiesterase-type-5 (PDE5) inhibitor

A class of drugs that block the enzyme responsible for breaking down cyclic guanosine monophosphate (cGMP), thereby enhancing smooth-muscle relaxation and vasodilation.

cGMP (cyclic guanosine monophosphate)

A second messenger molecule that mediates the vasodilatory effects of nitric oxide in vascular smooth muscle.

Priapism

A prolonged, often painful erection lasting more than four hours, which can lead to permanent tissue damage if not treated promptly.

Nitric oxide (NO)

A gaseous signalling molecule released by endothelial cells that initiates the production of cGMP, leading to vascular smooth-muscle relaxation.

Buying Vigora from Our Online Pharmacy

Patients who encounter limited availability or high out-of-pocket costs for brand-name Sildenafil can obtain Vigora through our online pharmacy. By sourcing the medication from licensed, internationally verified suppliers, we keep prices close to the manufacturer’s cost while maintaining stringent quality-control standards.

Every shipment is packaged discreetly, ensuring privacy throughout the delivery process. Our logistics network offers reliable options, such as express delivery within 7 days for many regions and standard airmail that typically arrives in 3 weeks. Because we operate as a pharmacy-broker service, we can provide access to medications that may not be stocked in local pharmacies, allowing you to obtain the treatment you need without unnecessary delay.

Choosing our service means you benefit from:

• Affordability: Competitive pricing that reduces financial barriers.
• Verified authenticity: All products are verified against regulatory pharmacopeias.
• Secure handling: Encrypted transactions and confidential customer records.
• Global reach: Delivery to a wide range of countries, respecting local import regulations.

Our online pharmacy is committed to supporting patients who need reliable, cost-effective access to generic Sildenafil Citrate such as Vigora.

Disclaimer

The information presented here about Vigora is intended for general educational purposes and does not replace personalized medical advice. Treatment decisions, including any off-label use, must be made under the guidance of a qualified healthcare professional. Readers are presumed to be responsible adults capable of making informed health choices. Our online pharmacy offers access to Vigora for individuals who may encounter limited availability through conventional pharmacy channels or who seek a more affordable generic option. Always consult a qualified provider before initiating, adjusting, or stopping any medication.