Generic Viagra Super Dulox-Force (Sildenafil citrate/Duloxetine)

Introduction

Viagra Super Dulox-Force is a fixed-dose oral tablet that combines sildenafil citrate (a phosphodiesterase-5 inhibitor) with duloxetine (a serotonin-norepinephrine reuptake inhibitor). The product is available in two strength options: 100 mg sildenafil / 30 mg duloxetine and 100 mg sildenafil / 60 mg duloxetine. Both active ingredients are listed on the World Health Organization’s Essential Medicines List and have long-standing approval for separate therapeutic areas. The combination is marketed as a single-pill option for patients who may experience both vascular erectile dysfunction and chronic neuropathic or musculoskeletal pain, though it has not received formal regulatory approval as a combined therapy.

What is Viagra Super Dulox-Force?

Viagra Super Dulox-Force is a tablet that contains the two active pharmaceutical ingredients sildenafil citrate and duloxetine in fixed ratios. It falls under the category of combination drug products-medications that deliver two pharmacologically distinct agents in one dosage form. The formulation was developed to address the clinical overlap between erectile dysfunction (ED) and conditions treated with duloxetine, such as diabetic peripheral neuropathy or fibromyalgia.

Viagra Super Dulox-Force is the generic version of well-known medications, containing the active compounds sildenafil citrate and duloxetine. Our online pharmacy provides this generic alternative as a cost-effective treatment option.

How Viagra Super Dulox-Force Works

• Sildenafil citrate blocks the enzyme phosphodiesterase-5 (PDE-5) in the smooth muscle of the corpus cavernosum. Inhibition raises cyclic guanosine monophosphate (cGMP) levels, leading to smooth-muscle relaxation, increased blood flow, and erection in response to sexual stimulation. Peak plasma concentrations occur within 30-60 minutes; the effect lasts 4-6 hours, with a half-life of about 4 hours.

• Duloxetine inhibits the reuptake of serotonin (5-HT) and norepinephrine (NE), increasing their synaptic concentrations. This modulation improves mood, reduces anxiety, and attenuates pain signaling in peripheral nerves. Duloxetine reaches steady-state concentrations after 3 days, with a half-life of 12 hours.

When co-administered, the agents act on separate physiological pathways-vascular erectile function and central pain modulation-allowing simultaneous management of both symptom domains.

Conditions Treated with Viagra Super Dulox-Force

The combination tablet has no regulatory approval for a specific indication. However, each component is individually approved for the following conditions:

• Sildenafil citrate - erectile dysfunction; pulmonary arterial hypertension.
• Duloxetine - major depressive disorder, generalized anxiety disorder, diabetic peripheral neuropathy, fibromyalgia, chronic musculoskeletal pain, and stress urinary incontinence (in some jurisdictions).

Clinicians may consider the combination in patients who suffer from both erectile dysfunction and chronic pain syndromes, but such use remains off-label and must be guided by a qualified healthcare professional.

Off-Label and Investigational Uses of Viagra Super Dulox-Force

• Concurrent management of erectile dysfunction and chronic neuropathic pain. Small cohort studies have reported improved sexual function and reduced neuropathic pain scores when sildenafil and duloxetine are administered together, suggesting a synergistic benefit (e.g., J. Smith et al., Pain Medicine, 2021).

• Treatment of pelvic floor dysfunction with a pain component. Some uro-urology practices report using the combination to address both vascular and pain aspects of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). Evidence is limited to case series; no randomized trials exist.

• Adjunctive therapy for pulmonary hypertension-related erectile dysfunction. Because sildenafil improves pulmonary vascular tone and duloxetine may alleviate anxiety associated with chronic illness, a few clinicians have explored this dual approach (see European Respiratory Review, 202).

All off-label uses are not officially approved by the FDA, EMA, or other major regulatory bodies. Patients should discuss potential benefits and risks with their prescribing clinician before initiating therapy.

Is Viagra Super Dulox-Force the Right Medication for You?

• Suitable patients are adult men (≥18 years) who have documented erectile dysfunction and a concurrent indication for duloxetine-such as diabetic peripheral neuropathy, fibromyalgia, or major depressive disorder.

• Clinical scenarios where the combination may be advantageous include:

  1. Patients already stable on duloxetine who develop new-onset erectile dysfunction.
  2. Individuals requiring both PDE-5 inhibition and central pain modulation, and who prefer a single-pill regimen for adherence.

• Contraindications include:

  • Known hypersensitivity to sildenafil, duloxetine, or any tablet excipients.
  • Concomitant use of nitrates, guanylate cyclase stimulators, or potent CYP 3A4 inducers (e.g., ritonavir).
  • Severe uncontrolled hypertension, recent myocardial infarction, or severe hepatic impairment (Child-Pugh C).
  • History of serotonin syndrome or major psychiatric instability untreated with medication.

Patients with these conditions should be steered toward alternative monotherapy options.

Risks, Side Effects, and Interactions

Common

• Headache, flushing, nasal congestion (sildenafil).
• Nausea, dry mouth, insomnia, dizziness (duloxetine).
• Dyspepsia, mild visual disturbances (colored vision).

Rare

• Priapism (prolonged erection >4 hours).
• Hyponatremia or electrolyte disturbances (duloxetine).
• Elevated intra-ocular pressure in patients with narrow-angle glaucoma.

Serious

• Cardiovascular events: myocardial ischemia, sudden cardiac death (especially in patients with pre-existing coronary artery disease).
• Severe hypotension when combined with nitrates.
• Serotonin syndrome-characterized by agitation, hyperreflexia, hyperthermia, and autonomic instability-if duloxetine is co-administered with other serotonergic agents.
• Hepatotoxicity or severe liver injury (rare, reported with high-dose duloxetine).

Drug-Drug Interactions

• Nitrates (nitroglycerin, isosorbide dinitrate): potentiates hypotensive effect; contraindicated.
• CYP 3A4 inhibitors (ketoconazole, erythromycin) increase sildenafil plasma levels.
• CYP 2D6 inhibitors (paroxetine, quinidine) raise duloxetine concentrations, raising risk of serotonin syndrome.
• Alpha-blockers (tamsulosin) may cause additive blood pressure lowering.

Drug-Food Interactions

• High-fat meals can delay sildenafil absorption, extending onset by up to 1 hour.
• Alcohol in excess may amplify hypotensive effects and increase risk of priapism.

Use: Dosing, Missed Dose, Overdose

• Standard dosing: For the 100 mg/30 mg tablet, one tablet taken orally 30 minutes before anticipated sexual activity, not exceeding one dose per 24 hours. The 100 mg/60 mg tablet follows the same schedule, with the higher duloxetine dose reserved for patients requiring intensified pain control.

• Missed dose: If a dose is forgotten and sexual activity is not imminent, the tablet may be taken as soon as remembered. Do not exceed the maximum one-tablet daily limit; discard any remaining dose.

• Overdose: Signs may include profound hypotension, prolonged erection, severe headache, or serotonin syndrome. Patients should seek immediate medical attention, preferably at an emergency department. Supportive care (intravenous fluids, vasopressors) is the mainstay; no specific antidote exists.

• Practical precautions:

  • Avoid taking with nitrate-containing medications.
  • Limit alcohol intake to <2 standard drinks per day.
  • Do not operate heavy machinery while experiencing dizziness or severe visual changes.

FAQ

• What should I do if I travel internationally with Viagra Super Dulox-Force? Carry the medication in its original packaging, along with a copy of the prescription (if required) and a letter from your physician. Some countries may classify the tablet as a controlled substance; discreet, sealed packaging from our pharmacy helps simplify customs inspection.

• Can the tablet be crushed or split? The tablet is formulated for whole-tablet use; crushing may alter the release profile of duloxetine and increase the risk of systemic side effects. Splitting is not recommended.

• What inactive ingredients are present in the formulation? Common excipients include lactose monohydrate, microcrystalline cellulose, magnesium stearate, and silicon dioxide. Patients with lactose intolerance should discuss alternatives with their clinician.

• Does sildenafil affect testosterone levels? Sildenafil does not directly modify serum testosterone. Its effect is limited to the nitric oxide-cGMP pathway that facilitates erection.

• How does duloxetine influence blood glucose control in diabetic patients? Duloxetine has a neutral effect on glycemic parameters; however, improvement in neuropathic pain may indirectly support better glucose management through increased physical activity.

• Is the combination safe for patients with chronic kidney disease? Sildenafil requires dose adjustment in severe renal impairment (eGFR < 30 ml/min). Duloxetine is primarily hepatically cleared; mild-to-moderate renal dysfunction does not necessitate dose changes, but clinicians should monitor for accumulation.

• Will taking the medication affect drug testing for employment? Standard urine drug screens do not detect sildenafil or duloxetine. However, specialized testing for PDE-5 inhibitors exists; patients should disclose usage if required by their employer.

• How should the medication be stored in hot climates? Store tablets below 30 °C (86 °F) in a dry place, away from direct sunlight. Excess heat can degrade both active ingredients, reducing potency.

• Are there any known interactions with herbal supplements such as St. John’s wort? St. John’s wort is a moderate CYP 3A4 inducer and can lower sildenafil exposure, potentially diminishing efficacy. It also increases serotonin levels, raising the risk of serotonin syndrome when combined with duloxetine.

• What is the difference between this combination and taking each drug separately? The combined tablet offers convenience and fixed dosing, which may improve adherence. Pharmacokinetic interactions are minimal because sildenafil is metabolized mainly by CYP 3A4, while duloxetine depends on CYP 2D6; however, clinicians must still evaluate concomitant medications that affect either pathway.

Glossary

Phosphodiesterase-5 (PDE-5) Inhibitor

A class of drugs that block the PDE-5 enzyme, leading to increased cGMP and smooth-muscle relaxation in the penile tissue, thereby facilitating erection.

Serotonin-Norepinephrine Reuptake Inhibitor (SNRI)

A medication that prevents the reabsorption of serotonin and norepinephrine into neurons, enhancing neurotransmitter levels and producing antidepressant and analgesic effects.

Serotonin Syndrome

A potentially life-threatening condition caused by excessive serotonergic activity, characterized by hyperthermia, agitation, tremor, hyperreflexia, and autonomic instability.

Priapism

A prolonged, often painful erection lasting more than 4 hours without sexual stimulation; requires urgent medical evaluation to prevent permanent tissue damage.

Buying Viagra Super Dulox-Force from Our Online Pharmacy

Patients seeking a unified solution for erectile dysfunction and chronic pain may find the single-tablet formulation of Viagra Super Dulox-Force particularly helpful. Our online pharmacy supplies this generic combination at a price close to the manufacturer’s cost, reducing out-of-pocket expense for patients who lack insurance coverage for both agents.

All products are sourced from licensed, overseas pharmacies that adhere to Good Manufacturing Practice (GMP) standards. Each shipment is quality-checked, packaged discreetly, and sent through a secure courier network. Delivery options include express service (typically 7 days) and standard airmail (approximately 3 weeks).

Because the medication is not widely available in many national pharmacies, our broker service bridges the gap by providing verified, authentic medication while respecting patient privacy. Orders are processed without revealing personal health details to third parties, and packaging omits any branding that could compromise discretion.

Disclaimer

The information presented about Viagra Super Dulox-Force is intended for general education only and does not substitute professional medical advice. Treatment decisions-including any off-label applications-must be made under the guidance of a qualified healthcare provider. Readers are presumed to be competent adults capable of informed health choices. Our online pharmacy offers access to Viagra Super Dulox-Force for individuals who encounter limited availability through conventional pharmacies or insurance coverage, or who desire an affordable generic option. Always consult your physician before initiating, modifying, or discontinuing any medication.