Generic Vardenafil With Dapoxetine (Vardenafil with Dapoxetine)

Introduction

Vardenafil with Dapoxetine is a fixed-dose oral tablet that combines two active agents: vardenafil, a phosphodiesterase-5 (PDE-5) inhibitor, and dapoxetine, a short-acting selective serotonin-reuptake inhibitor (SSRI). The combination is designed to treat two sexual-function disorders that often coexist in adult men: erectile dysfunction (ED) and premature ejaculation (PE). The tablet is available in a single strength of 20 mg vardenafil / 60 mg dapoxetine and is classified as a prescription medication in most jurisdictions. Primary therapeutic use is the concurrent management of ED and PE, offering a streamlined regimen that addresses both conditions with a single dose taken shortly before sexual activity.

What is Vardenafil with Dapoxetine?

• Definition - Vardenafil with Dapoxetine is a oral tablet that contains the active compounds vardenafil (20 mg) and dapoxetine (60 mg).
• Classification - It belongs to the pharmacologic groups of PDE-5 inhibitors (for erectile dysfunction) and short-acting SSRIs (for premature ejaculation).
• Development history - Vardenafil was approved for erectile dysfunction in the early s, while dapoxetine received approval for premature ejaculation in the s. Recognizing that many men experience both conditions, pharmaceutical research combined the two agents into a single fixed-dose formulation to improve adherence and simplify treatment.
• Manufacturer - The combination is produced by several licensed manufacturers; generic versions are distributed by multiple international suppliers.

Vardenafil with Dapoxetine is the generic version of well-known medications, containing the active compound Vardenafil with Dapoxetine. Our online pharmacy provides this generic alternative as a cost-effective treatment option. The product is marketed under brand names such as Priligy® (dapoxetine) and Levitra® (vardenafil) when the agents are offered separately.

How Vardenafil with Dapoxetine Works

1. Vardenafil component - Vardenafil selectively inhibits phosphodiesterase-5 in the smooth muscle of the corpus cavernosum. By preventing the breakdown of cyclic guanosine monophosphate (cGc), it enhances nitric-oxide-mediated vasodilation, leading to increased blood flow and erection in response to sexual stimulation. The onset of action is typically 30-60 minutes, and the therapeutic effect can last up to 12 hours, depending on dose and individual metabolism.

2. Dapoxetine component - Dapoxetine rapidly blocks the reuptake of serotonin at central synapses, raising serotonergic tone in the brainstem pathways that regulate ejaculatory latency. Because dapoxetine has a short half-life (≈ 19 hours) and is cleared quickly, it is taken on demand rather than daily. The drug usually shortens the intravaginal ejaculatory latency time (IELT) by 2-3 minutes when taken 1-3 hours before intercourse.

3. Combined effect - The fixed-dose tablet synchronises the pharmacokinetic profiles of both agents, allowing the patient to take a single pill shortly before sexual activity. The vardenafil component supports erection, while dapoxetine prolongs ejaculatory latency, addressing the two primary symptoms that constitute the “dual sexual dysfunction” syndrome.

Conditions Treated with Vardenafil with Dapoxetine

• Erectile Dysfunction (ED) - Vardenafil restores the physiological cascade that leads to penile erection in response to sexual stimulation. Clinical trials have shown statistically significant improvements in the International Index of Erectile Function (IIEF) scores compared with placebo.

• Premature Ejaculation (PE) - Dapoxetine reduces the likelihood of early ejaculation by enhancing serotonergic inhibition of the ejaculatory reflex. Randomised, double-blind studies demonstrate a meaningful increase in IELT and patient-reported satisfaction.

The combination is indicated for adult males who experience both ED and PE simultaneously, a situation that accounts for up to 30 % of men seeking sexual-health care.

Off-Label and Investigational Uses of Vardenafil with Dapoxetine

• Male infertility associated with ejaculatory dysfunction - Small pilot studies have explored dapoxetine’s ability to improve ejaculatory timing in men undergoing assisted reproductive techniques. Although data are encouraging, regulatory bodies have not approved this indication.

• Pulmonary arterial hypertension (PAH) - Vardenafil, like other PDE-5 inhibitors, has been investigated for vasodilatory effects in the pulmonary circulation. Evidence remains limited and off-label use should only occur under specialist supervision.

• Anxiety-related sexual performance issues - Because dapoxetine modulates serotonin, some clinicians have informally used it to address anxiety-driven loss of control during intercourse. No formal trials support efficacy, and safety has not been established for this purpose.

Important: Off-label applications are not sanctioned by the FDA, EMA, or other major regulators. Patients considering any non-approved use must discuss the potential risks and benefits with a qualified healthcare professional.

Is Vardenafil with Dapoxetine the Right Medication for You?

• Ideal candidates - Adult men (≥ 18 years) who have a documented diagnosis of both erectile dysfunction and premature ejaculation, and who prefer an on-demand regimen rather than daily therapy.

• Clinical scenarios favoring this combination -

  • Inconsistent success with separate agents (e.g., taking vardenafil and dapoxetine at different times).
  • Desire for simplified dosing: a single pill taken 1-3 hours before intercourse.
  • Situations where rapid onset and relatively short duration are advantageous (e.g., occasional sexual activity).

• Contra-indications - The medication should not be used by individuals with:

  • Known hypersensitivity to vardenafil, dapoxetine, or any excipients.
  • Concurrent use of nitrates (including nitroglycerin) or nitric-oxide donors.
  • Severe uncontrolled hypertension or recent cardiovascular events (myocardial infarction, stroke).
  • Severe hepatic impairment (Child-Pugh C) or moderate-to-severe renal failure (eGFR < 30 mL/min).
  • History of congenital long QT syndrome or other significant cardiac arrhythmias.

Patients with these conditions should seek alternative therapies.

Risks, Side Effects, and Interactions

Common

• Headache
• Flushing
• Nasal congestion
• Dyspepsia (indigestion)
• Dizziness
• Decreased libido

These events occur in ≥ 5 % of treated individuals and are usually mild to moderate in intensity.

Rare

• Visual disturbances (e.g., blurred vision, color tinge)
• Priapism (prolonged erection lasting > 4 hours)
• Mood changes (e.g., anxiety, irritability)
• Gastrointestinal upset (nausea, vomiting)

Rare events are reported in < 1 % of users but warrant prompt medical evaluation if they appear.

Serious

• Cardiovascular events such as myocardial infarction, stroke, or sudden cardiac death, particularly in patients with pre-existing heart disease.
• Severe hypotension, especially when combined with nitrates or alpha-blockers.
• Serotonin syndrome when dapoxetine is used together with other serotonergic drugs (e.g., SSRIs, MAO inhibitors, tramadol).

Any serious adverse reaction should be treated as a medical emergency.

Drug-Drug Interactions

• Nitrates (e.g., nitroglycerin, isosorbide dinitrate) - Potent vasodilation may lead to life-threatening hypotension.
• Alpha-blockers (e.g., tamsulosin, doxazosin) - May cause additive blood-pressure lowering; dose titration and careful monitoring are required.
• Other serotonergic agents - Increased risk of serotonin syndrome; avoid simultaneous use unless specifically directed by a specialist.
• CYP3A4 inhibitors (e.g., ketoconazole, erythromycin) - Can elevate vardenafil plasma concentrations, raising the risk of adverse events.

Food-Drug Interactions

• High-fat meals - May delay the absorption of vardenafil, reducing its effectiveness.
• Alcohol - Excessive intake can exacerbate vasodilatory side effects (flushing, dizziness) and impair sexual performance.

Use: Dosing, Missed Dose, Overdose

• Standard dosing - One tablet (20 mg vardenafil / 60 mg dapoxetine) taken orally with water 1-3 hours before anticipated sexual activity. The tablet should not be taken more than once per day.

• Missed dose - Because the medication is taken on demand, a missed dose simply means the patient will not have the drug’s effect for that sexual encounter. No rescue dosing is recommended; the next dose should be taken only after a full 24-hour interval has elapsed.

• Overdose - Symptoms may include severe hypotension, fainting, prolonged erection, intense headache, or cardiac arrhythmias. Immediate medical attention is essential. If overdose is suspected, seek emergency services or go to the nearest emergency department.

• Practical precautions -

  • Avoid taking the tablet with a full, high-fat meal; a light snack is acceptable.
  • Refrain from excessive alcohol consumption (≥ 3 drinks) on the day of dosing.
  • Do not operate heavy machinery or drive if dizziness or visual changes occur.

FAQ

• Can I travel internationally with Vardenafil with Dapoxetine?

  • Yes. Carry the medication in its original packaging with a copy of the prescription (if required by the destination). Keep it in your hand luggage to avoid temperature extremes in cargo holds.

• What does the tablet look like?

  • The generic tablet is typically round, film-coated, and marked with “20/60” on one side to denote the vardenafil and dapoxetine strengths. Inactive ingredients may include lactose, microcrystalline cellulose, and magnesium stearate.

• Is the combination tablet safe for men over 65?

  • Age alone is not a contraindication, but older adults often have comorbid cardiovascular disease or renal impairment that may increase risk. A thorough medical assessment is advisable before initiating therapy.

• How should I store the medication in a hot climate?

  • Store the tablets at controlled room temperature (15-30 °C). If you live in a region where ambient temperature frequently exceeds 30 °C, keep the bottle in a climate-controlled container or a cool part of the house, away from direct sunlight.

• Will the tablet show up on a standard drug test?

  • Vardenafil and dapoxetine are not typically screened for in employment-related drug tests. However, specialized testing can detect them if specifically requested.

• Can I take this medication if I am on antihypertensive therapy?

  • Most antihypertensives are compatible, but agents that cause vasodilation (e.g., alpha-blockers) may increase the risk of low blood pressure. Discuss any blood-pressure medications with your clinician before use.

• What is the difference between this combination and taking the two drugs separately?

  • The combined tablet reduces pill burden and synchronises timing, which may improve adherence. Pharmacokinetic profiles remain similar to the individual agents when taken at comparable doses.

• Is there any risk of dependence on dapoxetine?

  • Dapoxetine has a short half-life and low abuse potential. No evidence suggests physiological dependence, but psychological reliance on the medication for sexual performance can develop; counseling may be beneficial.

• How long does shipping usually take from our online pharmacy?

  • Standard airmail typically arrives within 2-3 weeks, while express delivery can be completed in 5-7 days, depending on the destination and customs processing.

• Are there any known interactions with herbal supplements?

  • St. John’s wort induces CYP3A4 and may reduce vardenafil effectiveness. Ginkgo biloba can increase bleeding risk when combined with anticoagulants and may theoretically enhance vasodilatory effects. Always disclose supplement use to your healthcare provider.

Glossary

Phosphodiesterase-5 (PDE-5) inhibitor

A class of drugs that block the enzyme PDE-5, leading to increased levels of cyclic guanosine monophosphate (cGMP) and enhanced smooth-muscle relaxation in the penis.

Selective serotonin-reuptake inhibitor (SSRI)

A medication that inhibits the reabsorption of serotonin into neurons, thereby elevating serotonergic activity in the central nervous system.

Intravaginal ejaculatory latency time (IELT)

The measured interval from vaginal penetration to ejaculation; a key objective metric in premature-ejaculation research.

Serotonin syndrome

A potentially life-threatening condition caused by excessive serotonergic activity, characterized by agitation, hyperthermia, tremor, and autonomic instability.

Buying Vardenafil with Dapoxetine from Our Online pharmacy

Patients who encounter high out-of-pocket costs, limited pharmacy stock, or restrictive insurance formularies can obtain Vardenafil with Dapoxetine through our online pharmacy. We operate as a pharmacy-broker service that partners with licensed overseas suppliers, allowing us to offer the medication at prices close to manufacturer rates.

• Affordability - By sourcing directly from verified manufacturers, we reduce middle-man mark-ups, providing a cost-effective alternative to brand-name products.
• Verified quality - Every batch is inspected for compliance with Good Manufacturing Practice (GMP) standards and accompanied by a certificate of analysis.
• Discreet delivery - Orders are packed in unbranded, tamper-evident packaging and shipped with privacy-focused labeling. Standard parcels typically arrive within 2-3 weeks; an express option is available for faster receipt.
• Global access - Our platform facilitates safe, legal acquisition of medications that may not be stocked locally, helping patients maintain continuity of care without unnecessary travel.

By choosing our online pharmacy, you gain a reliable, private, and financially sensible pathway to the treatment you need.

Disclaimer

The information presented about Vardenafil with Dapoxetine is intended solely for general educational purposes and does not replace professional medical advice. Decisions regarding any therapy-including off-label applications-must be made under the guidance of a qualified healthcare practitioner. Readers are presumed to be mature adults capable of evaluating health-related information responsibly. Our online pharmacy supplies Vardenafil with Dapoxetine to individuals who may encounter limited availability through conventional pharmacies, insurance-driven channels, or who are seeking economical generic options. Always consult a qualified medical professional before initiating, adjusting, or discontinuing any medication.