Generic Theo-24 Sr (Theophylline )

Introduction

Theo-24 Sr is a oral tablet that contains 200 mg of the methylxanthine Theophylline. It belongs to the class of bronchodilators and is primarily used to relax airway smooth muscle in chronic respiratory diseases. The medication is supplied as a sustained-release (SR) pill, allowing once-daily dosing for many adults. In addition to its approved role in asthma and chronic obstructive pulmonary disease (COPD), Theophylline has been investigated for several off-label indications such as apnea of prematurity and certain inflammatory lung conditions.

What is Theo-24 Sr?

Theo-24 Sr is the generic version of well-known medications, containing the active compound Theophylline. Our online pharmacy provides this generic alternative as a cost-effective treatment option.

• Classification: Methyl-xanthine bronchodilator
• Development history: Theophylline was first isolated from tea leaves in the early s and later synthesized for pharmaceutical use. It became one of the earliest oral treatments for asthma before the advent of modern inhaled corticosteroids.
• Manufacturer: The specific commercial manufacturer of Theo-24 Sr may vary by region; the formulation complies with pharmaco-peia standards for sustained-release tablets.
• Brand references: Theophylline is marketed under brand names such as Theo-24, Theolair, and Uniphyl.

How Theo-24 Sr Works

Theophylline exerts its therapeutic effect through several mechanisms:

1. Phosphodiesterase inhibition - By blocking phosphodiesterase-4, intracellular cyclic AMP (cAMP) rises, leading to relaxation of bronchial smooth muscle.
2. Adenosine receptor antagonism - The drug blocks adenosine A₁ and A₂ receptors, which reduces bronchoconstriction and inflammation mediated by mast cells.
3. Histone deacetylase (HDAC) activation - Low-dose Theophylline may enhance steroid sensitivity, providing an additive anti-inflammatory benefit.

These actions together improve airflow, reduce airway resistance, and can modestly diminish airway hyper-responsiveness. The sustained-release formulation provides a more stable plasma concentration, reducing peak-related side effects while maintaining bronchodilation throughout the day. Theophylline is metabolized hepatically by CYP1A2, with a half-life of 6-8 hours in healthy adults; smoking and certain drugs can accelerate clearance, whereas liver disease prolongs it.

Conditions Treated with Theo-24 Sr

Approved indications (FDA/EMA):

• Asthma - Used as an add-on therapy when inhaled corticosteroids and β₂-agonists do not achieve sufficient control.
• Chronic Obstructive Pulmonary Disease (COPD) - Helps reduce the frequency of exacerbations and improves exercise tolerance in patients with moderate to severe disease.

Why effective: Theophylline’s bronchodilatory and mild anti-inflammatory properties complement inhaled therapies, especially in patients with refractory symptoms or limited access to newer agents.

Off-Label and Investigational Uses of Theo-24 Sr

• Apnea of prematurity - Small clinical trials have shown that low-dose Theophylline can stimulate the respiratory centre in preterm infants, reducing apnea episodes. This use is not FDA-approved for adults and should only be considered under neonatal specialist supervision.
• Bronchiolitis in infants - Some pediatric studies suggest modest improvement in respiratory effort, but evidence remains inconsistent.
• Pulmonary hypertension - Preliminary data indicate that phosphodiesterase inhibition may lower pulmonary vascular resistance; however, robust trials are lacking.
• Post-operative respiratory support - Theophylline has been trialed to prevent airway obstruction after surgery, particularly in patients with obstructive sleep apnea, but results are not definitive.

All off-label applications lack formal regulatory endorsement. Patients should discuss potential benefits and risks with a qualified healthcare professional before initiating such use.

Is Theo-24 Sr the Right Medication for You?

• Suitable patients: Adults with persistent asthma or COPD who remain symptomatic despite optimized inhaled therapy, and who can adhere to regular blood-level monitoring when required.
• Particular scenarios:
  • Individuals who experience frequent nocturnal bronchospasm.
  • Patients who cannot tolerate higher doses of inhaled β₂-agonists due to tachycardia or tremor.
• Contra-indications:
  • Known hypersensitivity to Theophylline or other methyl-xanthines.
  • Uncontrolled cardiac arrhythmias, severe coronary artery disease.
  • Active seizures, recent myocardial infarction, or liver failure.
  • Pregnancy and breastfeeding are cautioned against unless benefits outweigh risks.

If any of these conditions apply, alternative therapies should be considered first.

Risks, Side Effects, and Interactions

Common

• Nausea, vomiting, or abdominal discomfort
• Headache or dizziness
• Insomnia or mild nervousness
• Palpitations or tachycardia

Rare

• Myalgia or muscle cramps
• Elevated liver enzymes
• Skin rash or pruritus

Serious

• Seizures (usually at supratherapeutic serum concentrations)
• Life-threatening arrhythmias (e.g., ventricular tachycardia)
• Severe hypotension

Drug-Drug Interactions

• CYP1A2 inhibitors (e.g., fluoroquinolones, cimetidine, oral contraceptives) → increase Theophylline levels, risk of toxicity.
• CYP1A2 inducers (e.g., smoking, carbamazepine, ritonavir) → lower levels, possible loss of efficacy.
• Macrolide antibiotics (erythromycin, clarithromycin) → potentiate toxicity.
• Theophylline + warfarin → may enhance anticoagulant effect; monitor INR closely.

Drug-Food Interactions

• Caffeine-containing foods/beverages add to the methyl-xanthine load, potentially raising serum concentrations.
• High-protein meals modestly enhance hepatic metabolism, possibly reducing efficacy.

Patients should inform their healthcare team of all concomitant medications, supplements, and dietary habits.

Use: Dosing, Missed Dose, Overdose

• Standard adult dose: 200 mg sustained-release tablet once daily. Dose adjustments are guided by serum Theophylline concentrations (target 10-20 µg/mL) and clinical response.
• Renal/hepatic impairment: Lower starting dose (e.g., 100 mg daily) and monitor levels closely.
• Missed dose: Take the missed tablet as soon as remembered unless it is within 6 hours of the next scheduled dose; in that case, skip the missed dose and resume the regular schedule. Do not double-dose.
• Overdose: Symptoms may include severe nausea, vomiting, seizures, and cardiac arrhythmias. Seek emergency medical attention immediately. Activated charcoal may be administered if presentation is early, and serum Theophylline levels should be measured for guidance on supportive therapy.

Practical precautions

• Take the tablet with a full glass of water; food does not significantly affect absorption but may reduce gastrointestinal irritation.
• Avoid alcohol, as it can increase CNS toxicity.
• Do not operate heavy machinery or drive until you know how the medication affects you, especially during initiation.

FAQ

• How should I store Theo-24 Sr tablets?

  • Keep the tablets in the original container at room temperature, away from moisture and direct sunlight. Do not refrigerate or freeze.

• Can I travel internationally with Theo-24 Sr?

  • Yes, but carry the medication in its original packaging with a copy of the prescription (or a pharmacist-verified label) to satisfy customs regulations in most countries.

• Do sustained-release tablets have a different onset of action compared to immediate-release forms?

  • The SR formulation releases Theophylline gradually, providing a steadier plasma level and a delayed peak (approximately 4-6 hours) versus immediate-release tablets, which peak within 1-2 hours.

• What inactive ingredients are present in Theo-24 Sr?

  • Typical excipients include microcrystalline cellulose, lactose monohydrate, magnesium stearate, and polymeric coating agents. Patients with severe lactose intolerance should verify with the supplier.

• Is blood-level monitoring required for every patient?

  • Routine serum concentration checks are recommended after the initial dose, after any dose change, and when interacting drugs are added or removed. Stable patients on a consistent dose may be monitored less frequently.

• Will smoking affect the effectiveness of Theo-24 Sr?

  • Yes. Smoking induces CYP1A2, accelerating Theophylline clearance and potentially reducing therapeutic levels. Smokers often require higher doses, but this must be balanced against toxicity risk.

• Can Theo-24 Sr be used in children?

  • Theophylline is approved for pediatric asthma in some jurisdictions, but the SR formulation is primarily studied in adults. Pediatric dosing must be individualized and supervised by a pediatric specialist.

• Are there any special considerations for elderly patients?

  • Age-related reductions in hepatic metabolism increase the risk of elevated serum levels. Start with a lower dose and monitor closely.

• Does Theo-24 Sr interact with hormonal contraceptives?

  • Yes, oral contraceptives inhibit CYP1A2, potentially raising Theophylline concentrations. Women using both should be monitored for symptoms of toxicity.

• Will taking Theo-24 Sr affect routine laboratory tests?

  • Theophylline does not typically interfere with standard chemistry panels, but it can modestly increase serum uric acid. Inform the laboratory if you are enrolled in a clinical trial.

• Is it safe to consume caffeine while on Theo-24 Sr?

  • Moderate caffeine intake is generally tolerated, but excessive consumption can push plasma Theophylline toward the upper therapeutic range, increasing side-effect risk.

Glossary

Pharmacokinetics

The study of how a drug is absorbed, distributed, metabolized, and excreted by the body.

Therapeutic window

The concentration range in which a medication provides clinical benefit without unacceptable toxicity.

CYP1A2

An enzyme in the liver that metabolizes many drugs, including Theophylline; its activity can be increased or decreased by other substances.

Sustained-release (SR)

A dosage form designed to release the active ingredient slowly over time, permitting less frequent dosing.

Buying Theo-24 Sr from Our Online Pharmacy

Patients who face limited availability, high out-of-pocket costs, or privacy concerns can obtain Theo-24 Sr through our online pharmacy. We source the medication from licensed, internationally-accredited suppliers, ensuring each batch meets stringent quality standards.

• Cost-effective pricing - Prices are set close to manufacturer cost, offering substantial savings compared with many local retail pharmacies.
• Verified quality - All tablets are inspected for potency, identity, and purity by certified laboratories before shipment.
• Discreet, reliable delivery - Orders are packaged in unbranded containers and shipped via secure courier services, typically within 7 days for express or 2-3 weeks for standard airmail, depending on destination.
• Privacy-first service - As a pharmacy broker, we handle all transactions confidentially, protecting personal data and providing a seamless online experience for patients who need access to international medications.

Our aim is to remove logistical and financial barriers, allowing you to focus on managing your respiratory health.

Disclaimer

The information presented about Theo-24 Sr is intended for general education only and does not replace professional medical advice. All therapeutic decisions, including those concerning off-label applications, should be undertaken under the guidance of a qualified healthcare provider. Readers are presumed to be responsible adults capable of making informed health choices. Our online pharmacy supplies Theo-24 Sr to individuals who may encounter limited access through conventional pharmacies or insurance formularies, or who seek affordable generic alternatives. Always discuss any medication changes, initiation, or discontinuation with your physician before proceeding.