Generic Tadasiva (Sildenafil citrate/tadalafil)

Introduction

Tadasiva is an oral tablet that combines the phosphodiesterase-5 (PDE5) inhibitors sildenafil citrate and tadalafil. Both agents belong to the same therapeutic class and are used to improve blood flow in specific vascular regions. The product is supplied in a fixed-dose tablet containing 100 mg of sildenafil citrate and 20 mg of tadalafil. It is marketed as a cost-effective option for the approved treatment of erectile dysfunction (ED) and for certain forms of pulmonary arterial hypertension (PAH). Some clinicians also prescribe the medication for off-label indications after reviewing the scientific evidence and individual patient circumstances.

What is Tadasiva?

Tadasiva is a tablet that contains the active ingredients sildenafil citrate and tadalafil. It is classified as a PDE5 inhibitor combination product. The formulation was developed to provide the rapid onset of sildenafil together with the longer duration of tadalafil in a single dose. The tablet is manufactured by a licensed pharmaceutical company that adheres to Good Manufacturing Practice (GMP) standards.

“Tadasiva is the generic version of well-known medications, containing the active compound sildenafil citrate/tadalafil. Our online pharmacy provides this generic alternative as a cost-effective treatment option.”

The product is sold in the 100 mg/20 mg strength and is intended for adult patients who meet the approved indications.

How Tadasiva Works

Sildenafil citrate and tadalafil block the enzyme phosphodiesterase-5 (PDE5). PDE5 normally degrades cyclic guanosine monophosphate (cG c) in smooth-muscle cells of the penis and the pulmonary vasculature. By inhibiting PDE5, Tadasiva raises intracellular cG c levels, which leads to relaxation of smooth muscle and dilation of blood vessels when nitric oxide is present.

• Onset: Sildenafil begins to work within 30-60 minutes; tadalafil’s effect can be observed in about 30 minutes.
• Duration: The sildenafil component lasts 4-6 hours, whereas tadalafil provides vascular effects for up to 36 hours. The combination therefore offers an early benefit with a prolonged therapeutic window.
• Clearance: Both drugs are metabolized primarily by the hepatic enzyme CYP3A4 and eliminated mainly via feces. Their half-lives differ (sildenafil ≈ 4 hours, tadalafil ≈ 17.5 hours), which explains the overlapping duration of action.

Conditions Treated with Tadasiva

Erectile Dysfunction (ED)

ED is the inability to achieve or maintain an erection sufficient for sexual activity. The increased blood flow generated by PDE5 inhibition directly addresses the underlying vascular insufficiency in most cases. Clinical trials of each component have demonstrated improvements in the International Index of Erectile Function (IIEF) scores, and the combination offers flexibility for patients who desire both rapid onset and extended durability.

Pulmonary Arterial Hypertension (PAH)

PAH is a progressive disease characterized by elevated pulmonary artery pressure, leading to right-ventricular strain. By dilating pulmonary vessels, sildenafil and tadalafil lower pulmonary vascular resistance, improve exercise capacity, and delay disease progression. Both agents are approved individually for PAH; the fixed-dose combination is used off-label in some jurisdictions under specialist supervision.

Off-Label and Investigational Uses of Tadasiva

• Benign Prostatic Hyperplasia (BPH)-related lower urinary tract symptoms: Small studies have shown that PDE5 inhibitors can improve urinary flow rates, likely through smooth-muscle relaxation in the prostate and bladder neck. Use for BPH is not approved by regulatory authorities and should only be considered after specialist review.

• Raynaud’s phenomenon: Limited case series suggest that sildenafil may reduce the frequency of digital vasospasm episodes. Evidence remains preliminary, and safety in this population has not been fully established.

• High-altitude pulmonary edema (HAPE) prophylaxis: Experimental data indicate that sildenafil’s pulmonary vasodilatory effect can mitigate HAPE in susceptible climbers. This indication is investigational and not endorsed by health agencies.

• Female sexual arousal disorder: Some phase-II trials explored PDE5 inhibition in women, showing modest improvements in clitoral blood flow. The benefit-risk profile remains uncertain, and the use is off-label.

Patients should discuss any off-label considerations with a qualified healthcare provider before initiating therapy.

Is Tadasiva the Right Medication for You?

Tadasiva is most appropriate for adult men with documented erectile dysfunction who desire a medication that provides both quick onset and a prolonged effect window. It is also a potential option for patients with pulmonary arterial hypertension when prescribed by a pulmonary specialist.

Recommended scenarios

• Men who have previously responded to either sildenafil or tadalafil but wish to reduce the number of tablets taken per month.
• Individuals who experience occasional “weekend-only” sexual activity and benefit from the extended coverage of tadalafil.

Contraindications & caution

• Concurrent use of nitrates (e.g., nitroglycerin) or nitric-oxide donors, due to risk of severe hypotension.
• Severe hepatic impairment (Child-Pugh C) or end-stage renal disease (dialysis-dependent).
• Uncontrolled hypertension (systolic > 180 mmHg or diastolic > 110 mmHg).
• Known hypersensitivity to sildenafil, tadalafil, or any tablet excipients.

Patients with a history of non-arteritic anterior ischemic optic neuropathy (NAION), retinitis pigmentosa, or significant cardiovascular disease should be evaluated carefully before use.

Risks, Side Effects, and Interactions

Common

• Headache
• Flushing
• Dyspepsia (indigestion)
• Nasal congestion
• Myalgia (muscle aches)

These events are usually mild to moderate and resolve without intervention.

Rare

• Visual disturbances (e.g., blurred vision, cyanopsia)
• Tinnitus or hearing loss
• Priapism (prolonged erection lasting > 4 hours)

Patients experiencing any of these should seek medical attention promptly.

Serious

• Severe hypotension, especially when combined with nitrates or alpha-blockers.
• Myocardial infarction or stroke in patients with unstable cardiovascular disease.
• Life-threatening allergic reactions (anaphylaxis).

Drug-drug interactions

• Nitrates (nitroglycerin, isosorbide dinitrate): additive vasodilation → contraindicated.
• Alpha-blockers (e.g., tamsulosin, prazosin): may cause symptomatic hypotension; dose titration required.
• CYP3A4 inhibitors (ketoconazole, ritonavir): increase plasma concentrations → dose reduction recommended.
• CYP3A4 inducers (rifampin, carbamazepine): decrease effectiveness → consider alternative therapy.

Drug-food interactions

• High-fat meals can delay the onset of sildenafil’s effect by up to 2 hours; tadalafil is less affected but still may experience delayed absorption.
• Grapefruit juice inhibits CYP3A4 and can raise drug levels; avoid concurrent consumption.

Patients should disclose all current medications, supplements, and dietary habits to their healthcare professional before starting Tadasiva.

Use: Dosing, Missed Dose, Overdose

Standard dosing

• Erectile dysfunction: One tablet taken orally with water approximately 30 minutes before sexual activity. Do not exceed one dose per 24 hours.
• Pulmonary arterial hypertension: One tablet taken once daily, preferably at the same time each day.

Dose adjustments may be required for patients aged ≥ 65 years, those with moderate hepatic impairment, or in the presence of CYP3A4 inhibitors.

Missed dose

• For PAH treatment, take the missed dose as soon as remembered on the same day; do not take a double dose to compensate.
• For ED, the medication is taken only as needed; a missed dose simply means the therapeutic opportunity is lost for that occasion.

Overdose

Signs of overdose include pronounced dizziness, severe hypotension, prolonged erection, and visual changes. If overdose is suspected, seek emergency medical care immediately. Supportive measures such as intravenous fluids and blood pressure monitoring are the mainstay of treatment.

Practical precautions

• The tablet may be taken with or without food; a high-fat meal may delay onset.
• Avoid excessive alcohol, which can amplify hypotensive effects.
• Do not operate heavy machinery or drive until you know how Tadasiva affects you.

FAQ

• What should I do if I travel internationally with Tadasiva? Keep the medication in its original packaging with the prescription label (if applicable). Carry it in your hand luggage to avoid temperature extremes in cargo holds, and be aware of the destination country’s import regulations for prescription drugs.

• Does Tadasiva have a distinctive tablet shape or color? The tablet is round, bicolored (blue on one side, white on the other), and bears the imprint “TS-100/20”. Appearance can vary slightly between manufacturing batches, but the imprint remains consistent for identification.

• Are there any inactive ingredients that could cause allergies? Inactive components include microcrystalline cellulose, magnesium stearate, and lactose monohydrate. Patients with lactose intolerance should discuss alternatives, although the lactose content is low and typically well tolerated.

• Will taking Tadasiva affect routine drug testing at work? Standard workplace drug screens do not test for PDE5 inhibitors. However, specialized testing (e.g., forensic toxicology) could detect sildenafil or tadalafil metabolites if specifically requested.

• Can women use Tadasiva for any condition? The medication is not approved for any female indication. Off-label use for female sexual arousal disorders has been studied, but safety and efficacy remain unestablished. Women should consult a specialist before any consideration.

• How does the combination of sildenafil and tadalafil compare to using each drug alone? The combination aims to merge the rapid onset of sildenafil with the longer duration of tadalafil, potentially reducing the need for multiple tablets. Clinical equivalence to monotherapy has not been formally evaluated in large trials, so individual response may vary.

• Is it safe to store Tadasiva in a bathroom cabinet? The tablet should be stored at room temperature (20-25 °C) away from moisture and direct sunlight. A bathroom cabinet may be exposed to humidity; a dry, climate-controlled area such as a kitchen drawer or bedroom nightstand is preferable.

• What is the impact of kidney disease on Tadasiva dosing? In patients with severe renal impairment (creatinine clearance < 30 mL/min), the drug’s clearance is reduced, and a lower starting dose is advised. Moderate impairment generally does not require adjustment.

• Can Tadasava be taken with over-the-counter supplements like L-arginine? L-arginine may increase nitric oxide production, theoretically enhancing the effect of PDE5 inhibitors. While no major safety concerns have been documented, concurrent use could increase the risk of hypotension, so patients should consult their physician.

• Is there a risk of developing tolerance to Tadasiva over time? Long-term use of PDE5 inhibitors does not typically lead to pharmacologic tolerance. However, psychological factors or progression of underlying disease may reduce perceived effectiveness, warranting reevaluation.

Glossary

Phosphodiesterase-5 (PDE5) inhibitor

A class of drugs that block the PDE5 enzyme, leading to increased levels of cyclic guanosine monophosphate (cG c) and resulting in smooth-muscle relaxation and vasodilation.

cG c (Cyclic guanosine monophosphate)

A second messenger molecule that mediates smooth-muscle relaxation in response to nitric oxide signaling.

Pulmonary arterial hypertension (PAH)

A condition characterized by high blood pressure in the arteries of the lungs, causing strain on the right side of the heart and reduced exercise capacity.

Priapism

An erection that persists for more than four hours and is not related to sexual stimulation; it is a medical emergency.

Buying Tadasiva from Our Online Pharmacy

Patients who encounter limited availability or high out-of-pocket costs for brand-name PDE5 inhibitors can obtain Tadasiva through our online pharmacy. We source the medication exclusively from licensed, GMP-certified manufacturers, ensuring that each batch meets stringent quality standards.

• Cost efficiency: Because Tadasiva is a generic formulation, the price is close to the product’s manufacturing cost, providing a significant saving compared with branded alternatives.
• Verified quality: Every shipment is accompanied by a certificate of analysis and batch-specific documentation confirming purity and potency.
• Discrete delivery: Packages are sealed in unmarked envelopes and dispatched via a trusted courier service, typically arriving within 7 days for express shipping or 2-3 weeks for standard airmail.
• Privacy-first approach: As a pharmacy broker service, we partner with overseas licensed pharmacies while safeguarding personal data. Your order is handled confidentially, and no identifying information appears on the outside of the package.

Our platform offers a reliable, affordable gateway to Tadasiva for individuals who may otherwise face barriers through conventional pharmacy channels.

Disclaimer

The content presented about Tadasiva is intended for informational purposes only and does not substitute professional medical advice. Treatment decisions-including any off-label applications-must be made under the direct supervision of a qualified healthcare practitioner. Readers are assumed to be competent adults capable of making informed health choices. Our online pharmacy provides access to Tadasiva for individuals who encounter limited supply through conventional pharmacies, insurance-based prescription programs, or who are seeking cost-effective generic alternatives. Always consult a qualified clinician before initiating, modifying, or discontinuing any medication.