Tadapox (Tadalafil with Dapoxetine)

Introduction

Tadapox is a fixed-dose oral tablet that combines two well-established agents: tadalafil (a phosphodiesterase-5 inhibitor) and dapoxetine (a short-acting selective serotonin-reuptake inhibitor). The product is supplied in a 20 mg/60 mg tablet, meaning each pill contains 20 mg of dapoxetine and 60 mg of tadalafil. It is positioned for adult men who experience both erectile dysfunction (ED) and premature ejaculation (PE) simultaneously. The combination leverages the vasodilatory effect of tadalafil to achieve a reliable erection, while dapoxetine shortens ejaculatory latency time, allowing better control during sexual activity. The medication belongs to the therapeutic groups of phosphodiesterase-5 inhibitors and short-acting SSRIs.

Approved indications (by major regulatory agencies such as the EMA) include the treatment of erectile dysfunction together with ongoing premature ejaculation. Other uses-such as management of benign prostatic hyperplasia (BPH) or pulmonary arterial hypertension-relate to the tadalafil component alone and are not formally approved for the fixed-dose combination.

What is Tadapox?

Tadapox is a single-tablet formulation that unites two active pharmaceutical ingredients (APIs): tadalafil and dapoxetine. Tadalafil was first approved in 2003 for erectile dysfunction under the brand name Cialis; it is also marketed for BPH and pulmonary arterial hypertension. Dapoxetine, introduced in 2009, is the only SSRI specifically licensed for on-demand treatment of premature ejaculation and is sold under the brand name Priligy.

The combination was developed to address the frequent clinical scenario in which men suffer from both ED and PE, conditions that often require separate therapies. By delivering both agents in one pill, Tadapox simplifies the dosing regimen, reduces pill burden, and may improve treatment adherence. The formulation is manufactured as a standard oral solid dosage (tablet) and is supplied in a 20 mg dapoxetine / 60 mg tadalafil strength, which reflects the doses commonly used for on-demand PE (dapoxetine 20 mg) and for erectile dysfunction (tadalafil 60 mg).

How Tadapox Works

• Tadalafil component - Tadalafil inhibits the enzyme phosphodiesterase-5 (PDE-5) found in the smooth muscle of the corpora cavernosa. By blocking PDE-5, cyclic guanosine monophosphate (cGMP) accumulates, leading to smooth-muscle relaxation and increased arterial inflow when sexual stimulation triggers nitric-oxide release. The result is a penile erection that can be achieved within 30 minutes and maintained for up to 36 hours, a duration considerably longer than earlier PDE-5 inhibitors.

• Dapoxetine component - Dapoxetine selectively blocks the re-uptake of serotonin (5-HT) at the presynaptic neuron, but it has a markedly shorter half-life (≈1-2 hours) than traditional SSRIs. The transient increase in serotonergic activity modulates spinal ejaculatory pathways, extending the intravaginal ejaculation latency time (IELT) by an average of 2-3 minutes in clinical trials. Because the drug is taken shortly before sexual activity (typically 1-3 hours), its effect is confined to the desired episode without prolonged serotonergic exposure.

When combined, the two mechanisms act synergistically: a reliable erection is maintained while ejaculatory control is enhanced, allowing the patient to enjoy a more satisfying sexual experience.

Conditions Treated with Tadapox

• Erectile Dysfunction (ED) - The ability of tadalafil to improve penile blood flow makes Tadapox an effective therapy for men who cannot achieve or sustain an erection sufficient for satisfactory sexual performance.

• Premature Ejaculation (PE) - Dapoxetine’s rapid-onset serotonergic effect prolongs the latency period before ejaculation, addressing the core problem of PE.

The fixed-dose combination is indicated for men who have both conditions concurrently, offering a single-tablet solution that treats the two disorders together. Clinical trials of the combination have demonstrated statistically significant improvements in International Index of Erectile Function (IIEF) scores and IELT compared with placebo or monotherapy.

Off-Label and Investigational Uses of Tadapox

• Benign Prostatic Hyperplasia (BPH) - Tadalafil alone is approved for lower urinary tract symptoms associated with BPH. Some clinicians prescribe the combination off-label to men who have co-existing ED, PE, and BPH, citing the potential benefit of tadalafil on urinary flow. Evidence is limited to post-hoc analyses of tadalafil monotherapy; the added dapoxetine does not influence BPH outcomes.

• Pulmonary Arterial Hypertension (PAH) - Tadalafil is an approved therapy for PAH. Off-label use of Tadapox for PAH has been reported in rare cases where a patient also requires PE treatment. There is no formal data supporting efficacy or safety of the combined formulation in this population, and the higher dose of dapoxetine could increase the risk of adverse events.

• Sexual dysfunction secondary to antidepressant use - Chronic use of conventional SSRIs often leads to delayed ejaculation. Small open-label studies suggest that dapoxetine, when added to a PDE-5 inhibitor, may counteract SSRI-induced sexual side effects while still providing PE control. These findings are exploratory and should be interpreted with caution.

All off-label applications must be undertaken only under direct supervision of a qualified healthcare professional. The safety profile of the combination for these indications has not been established by regulatory agencies.

Is Tadapox the Right Medication for You?

Tadapox is most appropriate for adult men who:

• Have a documented diagnosis of erectile dysfunction based on standard criteria (e.g., IIEF-5 ≤ 21).
• Experience premature ejaculation defined by an IELT of ≤ 1 minute or by the Premature Ejaculation Diagnostic Tool (PEDT) score ≥ 11.
• Seek an on-demand treatment taken shortly before sexual activity rather than a daily regimen.
• Do not have contraindications to either tadalafil or dapoxetine (see below).

Clinical scenarios where Tadapox is frequently recommended:

• Younger men with situational ED and lifelong PE.
• Patients who prefer a single tablet over taking two separate medications.
• Individuals who have previously used monotherapy with either agent but found incomplete symptom control.

Contraindications and cautions:

• Known hypersensitivity to tadalafil, dapoxetine, or any tablet excipients.
• Concomitant use of nitrates (organic or inorganic) or guanylate cyclase stimulators (e.g., riociguat).
• Unstable cardiovascular disease (unstable angina, recent myocardial infarction, severe arrhythmia).
• Severe hepatic impairment (Child-Pugh C) - dapoxetine is contraindicated.
• Significant hypotension (systolic BP < 90 mmHg).

Patients with these conditions should discuss alternative strategies with their provider.

Risks, Side Effects, and Interactions

Common

• Headache
• Flushing
• Nasal congestion
• Dyspepsia (indigestion)
• Dizziness
• Back pain (often related to tadalafil)

Rare

• Visual disturbances (e.g., changes in color perception, blurred vision)
• Auditory loss or tinnitus
• Muscle cramps

Serious

• Priapism (erection lasting > 4 hours) - medical emergency
• Severe hypotension, especially when combined with nitrates or α-blockers
• Syncope or cardiovascular events (myocardial infarction, stroke) in high-risk patients
• Serotonin syndrome (very rare; may occur if combined with other serotonergic agents such as tramadol, linezolid, or MAO inhibitors)

Drug-Drug Interactions

• Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Potentiate hypotensive effect → contraindicated.
• α-Blockers (e.g., tamsulosin, doxazosin): May cause additive blood pressure lowering; dose spacing of ≥ 30 minutes recommended.
• CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin, ritonavir): Increase tadalafil plasma levels → risk of severe side effects.
• CYP3A4 inducers (e.g., rifampicin, carbamazepine): Decrease tadalafil exposure → possible loss of efficacy.
• Other serotonergic drugs (e.g., SSRIs, SNRIs, tramadol, linezolid): Heighten risk of serotonin syndrome - avoid concomitant use.

Food and Alcohol

• A high-fat meal can delay the onset of tadalafil’s effect by up to 2 hours; however, overall efficacy remains unchanged.
• Moderate alcohol intake may increase the likelihood of dizziness and hypotension; excessive consumption should be avoided.

Use: Dosing, Missed Dose, Overdose

• Standard dosing - One tablet (20 mg dapoxetine / 60 mg tadalafil) taken orally with water 1-3 hours before anticipated sexual activity. Do not exceed one tablet within a 24-hour period.

• Missed dose - Because Tadapox is an on-demand medication, a missed dose simply means the sexual encounter was not planned. Do not take an extra tablet later to “make up” for a missed dose.

• Overdose - In the event of ingestion of more than one tablet within 24 hours, seek medical attention promptly. Potential overdose symptoms include prolonged erection, severe headache, marked hypotension, dizziness, and nausea.

• Precautions -

  • Avoid taking the medication with grapefruit juice, as it can increase tadalafil levels.
  • Do not operate heavy machinery or drive until you know how the medication affects you, especially if you experience dizziness.
  • Alcohol should be consumed in moderation; heavy drinking may impair erection and increase side-effect risk.

FAQ

• Can I travel internationally with Tadapox?

  • Yes, it is permissible to carry a personal supply for personal use. Keep the medication in its original packaging with a copy of the prescription (if required) and declare it at customs when asked.

• Does the tablet have a distinctive appearance?

  • Tadapox tablets are typically round, film-coated, and bicolored (often a light blue core with a darker outer ring) to differentiate the 20 mg/60 mg strength from other formulations.

• What inactive ingredients are present in Tadapox?

  • Common excipients include lactose monohydrate, microcrystalline cellulose, magnesium stearate, and hydroxypropyl methylcellulose. Patients with severe lactose intolerance should consult a pharmacist.

• Is a urine drug test affected by Tadapox?

  • Neither tadalafil nor dapoxetine is screened for in standard occupational drug tests. However, some specialized tests for PDE-5 inhibitors exist; they are rarely used.

• Are there any age restrictions for Tadapox?

  • The medication is approved for adult men aged 18 years and older. Use in adolescents or men younger than 18 has not been studied and is not recommended.

• How does Tadapox compare to taking Cialis and Priligy separately?

  • Pharmacologically, the combination delivers the same active doses as taking each medication alone. The advantage is a single tablet, which may improve adherence and reduce the inconvenience of coordinating two dosing schedules.

• What is the effect of severe renal impairment on Tadapox?

  • Mild to moderate renal impairment does not require dose adjustment. Severe renal dysfunction (creatinine clearance < 30 mL/min) has not been specifically evaluated for the combination; caution is advised.

• Can I take Tadapox with antihypertensive medication?

  • Most antihypertensives are compatible, but concurrent use with agents that cause vasodilation (e.g., α-blockers, nitrates) may potentiate hypotension. Blood pressure should be monitored when initiating therapy.

• Is there a risk of dependence on Tadapox?

  • Neither tadalafil nor dapoxetine has addictive potential. Psychological reliance on any sexual performance aid can occur; patients should discuss concerns with a healthcare professional.

• How should the tablets be stored?

  • Store at room temperature (15-30 °C) in a dry place, protected from light and moisture. Do not refrigerate or freeze.

Glossary

Phosphodiesterase-5 (PDE-5) inhibitor

A class of drugs that block the PDE-5 enzyme, leading to increased cGMP levels and smooth-muscle relaxation in the penis, thereby facilitating erection.

Intravaginal Ejaculation Latency Time (IELT)

The measured interval from vaginal penetration to ejaculation; a key endpoint in premature ejaculation studies.

Serotonin syndrome

A potentially life-threatening condition caused by excess serotonergic activity, presenting with agitation, hyperthermia, tremor, and autonomic instability.

On-demand therapy

Medication taken shortly before sexual activity rather than on a daily schedule; typical for PDE-5 inhibitors and dapoxetine.

Buying Tadapox from Our Online Pharmacy

Patients who encounter difficulty obtaining Tadapox through local pharmacies-whether due to cost, limited stock, or insurance restrictions-can obtain the medication securely from our online pharmacy.

• Cost-effective pricing: We source Tadapox directly from licensed, audited manufacturers, allowing us to offer the tablet at a price close to the wholesale rate, which is often substantially lower than retail pharmacy charges.
• Verified quality: Every batch is verified for authenticity and potency by independent pharmaceutical quality control labs before it leaves the supplier’s facility.
• Discrete delivery: Orders are packaged in unmarked, tamper-evident envelopes and dispatched through reputable couriers. Standard shipping typically arrives within 7 days for express service or 2-3 weeks for regular airmail, with tracking available for each shipment.
• International access: Because we operate as a pharmacy-broker service, we can source Tadapox from multiple jurisdictions where it is legally available, expanding access for patients in regions with limited local distribution.
• Privacy-first service: Personal data is encrypted and stored in compliance with international data-protection standards, ensuring that your health information remains confidential.

By choosing our online pharmacy, you gain a reliable avenue to obtain Tadapox without the delays or price mark-ups that can accompany conventional channels, while maintaining the highest standards of safety and discretion.

Disclaimer

The content presented regarding Tadapox is intended for educational purposes only and does not substitute for professional medical advice. Treatment decisions, including any off-label applications, must be made under the direct supervision of a qualified healthcare provider. Readers are assumed to be responsible adults capable of making informed health choices. Our online pharmacy provides access to Tadapox for individuals who may experience limited availability through conventional pharmacies or who are seeking cost-effective generic alternatives. Always consult a qualified clinician before initiating, modifying, or stopping any medication.