Super Zhewitra (Vardenafil with Dapoxetine)

Introduction

Super Zhewitra is a fixed-dose oral tablet that combines the phosphodiesterase-5 (PDE5) inhibitor vardenafil with the short-acting selective serotonin reuptake inhibitor dapoxetine. The product is manufactured as a 20 mg/60 mg tablet and belongs to the therapeutic class of agents used for erectile dysfunction (ED) and premature ejaculation (PE). Vardenafil improves penile blood flow, while dapoxetine prolongs the time to ejaculation. The combination is approved in several jurisdictions for the concurrent treatment of men with both ED and PE. Off-label investigations have explored its use in female sexual arousal disorder, pulmonary hypertension, and certain psychosexual conditions, but these indications are not formally sanctioned by regulatory agencies.

What is Super Zhewitra?

Super Zhewitra is the generic version of well-known medications, containing the active compound vardenafil with dapoxetine. Our online pharmacy provides this generic alternative as a cost-effective treatment option.

• Classification: Fixed-dose combination of a PDE5 inhibitor (vardenafil) and a short-acting SSRI (dapoxetine).
• Development history: Vardenafil was first approved for ED in 2003 (brand name Levitra). Dapoxetine received approval for PE in Europe in 2009 (brand name Priligy). The combination leverages complementary mechanisms to address two common male sexual disorders in a single tablet.
• Manufacturer: The specific commercial manufacturer of Super Zhewitra varies by region; it is produced under Good Manufacturing Practice (GMP) conditions and supplied to licensed distributors.

How Super Zhewitra Works

Vardenafil blocks the enzyme phosphodiesterase-5 in the smooth muscle of the corpus cavernosum. By preventing the breakdown of cyclic guanosine monophosphate (cGMP), it enhances nitric-oxide-mediated vasodilation, allowing increased arterial inflow and erection when sexual stimulation is present.

Dapoxetine selectively inhibits the serotonin transporter, modestly raising synaptic serotonin levels for several hours after ingestion. Elevated serotonin lengthens the ejaculatory latency period by dampening spinal reflex pathways that trigger emission.

When taken together, the 20 mg dose of vardenafil typically reaches peak plasma concentrations within 30-60 minutes, providing an erection-facilitating effect lasting up to 4-5 hours. Dapoxetine’s peak occurs at about 1 hour, and its half-life is roughly 1.5 hours, giving a therapeutic window that aligns with sexual activity planned within a few hours after dosing.

Conditions Treated with Super Zhewitra

• Erectile Dysfunction (ED): Vardenafil improves penile rigidity and sustainment of erection in response to sexual stimulation. Clinical trials demonstrate efficacy comparable to other PDE5 inhibitors, with onset in 15-30 minutes.
• Premature Ejaculation (PE): Dapoxetine increases intravaginal ejaculatory latency time (IELT) by 1-3 minutes compared with placebo, offering symptom relief for men whose IELT is ≤ 1 minute.

The combined formulation is indicated for men who experience both ED and PE simultaneously, simplifying therapy and improving adherence.

Off-Label and Investigational Uses of Super Zhewitra

• Female Sexual Arousal Disorder (FSAD): Small pilot studies have evaluated PDE5 inhibitors plus SSRIs in women with low sexual desire and arousal. Results suggest modest improvement, but safety data remain limited.
• Pulmonary Arterial Hypertension (PAH): Vardenafil alone has been studied for PAH due to its vasodilatory properties. The combination with dapoxetine is not approved for this indication; any use would be experimental and require specialist oversight.
• Psychogenic Erectile Dysfunction: In cases where anxiety contributes to ED, short-acting SSRIs may reduce performance anxiety. Evidence is anecdotal and not sufficient for formal endorsement.

These applications have not received approval from the FDA, EMA, or other major regulators. Patients should discuss any off-label consideration only with a qualified healthcare provider.

Is Super Zhewitra the Right Medication for You?

• Ideal candidates:

  • Adult men (≥ 18 years) diagnosed with both ED and PE.
  • Individuals who prefer a single tablet rather than separate prescriptions.
  • Patients without contraindications to either PDE5 inhibitors or SSRIs.

• Clinical scenarios where it is particularly recommended:

  • Men who have achieved satisfactory erections with a PDE5 inhibitor but still experience rapid ejaculation.
  • Patients who have previously used dapoxetine alone but also require assistance with erection quality.

• Contraindications / cautions:

  • Use of nitrates (e.g., nitroglycerin) or nitric-oxide donors - risk of severe hypotension.
  • Severe cardiovascular disease (unstable angina, recent myocardial infarction, uncontrolled hypertension).
  • Concomitant use of potent CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin) which can raise vardenafil levels.
  • Known hypersensitivity to either component or to any listed excipients.

If any of these conditions apply, alternative therapies should be considered.

Risks, Side Effects, and Interactions

Common

• Headache
• Flushing
• Nasal congestion
• Dyspepsia (indigestion)
• Dizziness
• Nausea

These events are typically mild to moderate and often resolve without intervention.

Rare

• Visual disturbances (e.g., altered colour perception, blurred vision)
• Auditory changes (tinnitus, hearing loss)
• Priapism (prolonged erection lasting > 4 hours) - requires emergency evaluation.

Serious

• Cardiovascular events (myocardial infarction, stroke) in patients with pre-existing heart disease.
• Severe hypotension, especially when combined with nitrates or alpha-blockers.
• Allergic reactions (urticaria, angio-edema, anaphylaxis).

Drug-drug interactions

• CYP3A4 inhibitors (ketoconazole, itraconazole, ritonavir) - increase vardenafil exposure → dose reduction may be needed.
• CYP3A4 inducers (rifampicin, carbamazepine) - decrease efficacy of vardenafil.
• Other serotonergic agents (SSRIs, SNRIs, MAO inhibitors, tramadol, linezolid) - additive risk of serotonin syndrome; avoid concomitant use.
• Alpha-blockers (tamsulosin, doxazosin) - may potentiate hypotensive effect; monitor blood pressure.

Drug-food interactions

• High-fat meals can delay vardenafil absorption, postponing onset of action by up to 1 hour.
• Alcohol in excess can exacerbate dizziness and hypotension; moderate consumption is advisable.

Patient safety tips

• Do not take more than one tablet within 24 hours.
• Avoid driving or operating heavy machinery until you know how the medication affects you.
• Discontinue use and seek medical attention if a painful erection persists beyond 4 hours.

Use: Dosing, Missed Dose, Overdose

• Standard dosing: One tablet (20 mg vardenafil / 60 mg dapoxetine) taken orally with water 30 minutes to 1 hour before sexual activity. Do not exceed one tablet per day.
• Dose adjustments: For patients with moderate hepatic impairment, a reduced dose of 10 mg/30 mg may be considered. Renal impairment does not significantly affect clearance, but caution is advised in severe cases.
• Missed dose: If sexual activity is not anticipated within 24 hours, simply omit the dose. Do not take an extra tablet to “make up” for a missed dose.
• Overdose: Signs may include severe hypotension, fainting, prolonged erection, or intense nausea. Seek emergency medical care immediately. Gastric lavage or activated charcoal may be employed if presentation is within a short time frame.

Practical precautions

• Take the tablet on an empty stomach or with a light meal for optimal absorption.
• Limit alcohol intake to ≤ 2 standard drinks per occasion.
• Refrain from using recreational “poppers” (nitrite inhalants) due to additive vasodilatory effects.

FAQ

• What should I do if I experience a painful erection lasting more than four hours? Seek emergency medical attention immediately; this condition (priapism) can cause permanent tissue damage if not treated promptly.

• Can I store Super Zhewitra in a bathroom cabinet where the temperature fluctuates? Store the tablets at controlled room temperature (20-25 °C). Avoid excess heat, humidity, and direct sunlight to maintain potency.

• Is the tablet coated, and does that affect swallowing? Yes, Super Zhewitra tablets have a film coating designed for smooth swallowing and to protect the active ingredients from moisture.

• Are there any differences in the inactive ingredients compared with brand-name products? The formulation contains common fillers such as lactose, microcrystalline cellulose, and magnesium stearate. These are listed on the package insert; patients with specific excipient allergies should review them carefully.

• Will travel across international borders with Super Zhewitra cause customs issues? Because the medication is a prescription-only product in most countries, it is advisable to carry a copy of the prescription or a doctor’s letter. Some jurisdictions may restrict import of combination PDE5/SSRI tablets.

• Can I take Super Zhewitra if I am on antihypertensive medication? Concurrent use is generally safe, but additive blood-pressure-lowering effects can occur, especially with alpha-blockers. Consult your prescriber to monitor blood pressure.

• Does the medication affect laboratory drug testing? Standard drug screens do not detect vardenafil or dapoxetine. However, specialized testing for PDE5 inhibitors exists and may be requested in certain occupational settings.

• How long does the tablet remain effective after the expiration date? Stability data support potency up to the printed expiration date when stored properly. After that, efficacy and safety cannot be guaranteed.

• What is the recommended storage period after opening the bottle? The tablet bottle is sealed; once opened, keep the container tightly capped and use the contents within 12 months, provided they have not passed the expiration date.

• Is it safe to use Super Zhewitra with over-the-counter sleep aids? Some sleep aids contain antihistamines or diphenhydramine, which can increase sedation and potentially worsen dizziness. Use caution and discuss with a healthcare professional.

Glossary

Phosphodiesterase-5 (PDE5) inhibitor

A class of drugs that block the PDE5 enzyme, preventing breakdown of cGMP and thereby promoting smooth-muscle relaxation in the penis.

Short-acting SSRI

Selective serotonin reuptake inhibitors with a rapid onset and short half-life, used primarily for premature ejaculation (e.g., dapoxetine).

Intravaginal ejaculatory latency time (IELT)

The measured interval from vaginal penetration to ejaculation; a key endpoint in premature-ejaculation research.

Serotonin syndrome

A potentially life-threatening condition caused by excessive serotonergic activity, characterized by agitation, hyperthermia, tremor, and autonomic instability.

Buying Super Zhewitra from Our Online Pharmacy

Super Zhewitra can be obtained securely through our online pharmacy. We source the medication exclusively from licensed, GMP-certified manufacturers, ensuring that every tablet meets stringent quality standards. Because we operate as a pharmacy-broker service, we can offer the product at a price close to the manufacturer’s cost, delivering a clear financial advantage over many domestic retail pharmacies.

Our fulfillment network provides discreet packaging and reliable delivery options, typically within 7 days for express shipments and around 3 weeks for standard airmail. The process is fully digital, safeguarding your privacy while granting access to an international medication that may be unavailable locally or restricted by insurance formularies.

Choosing our service means you receive a verified, authentic product without the markup common to brick-and-mortar pharmacies. We prioritize safety, transparency, and confidentiality, making the acquisition of Super Zhewitra straightforward and trustworthy for patients seeking an affordable, high-quality solution.

Disclaimer

The information presented about Super Zhewitra is intended for general educational purposes only and does not substitute for professional medical advice. Treatment choices, including any off-label applications, should be made under the direct supervision of a qualified healthcare provider. Readers are presumed to be competent adults capable of informed health decisions. Our online pharmacy supplies Super Zhewitra to individuals who may encounter limited access through conventional pharmacies, insurance coverage, or who are looking for cost-effective generic options. Always discuss with a qualified clinician before initiating, modifying, or discontinuing any medication.