Super Avana (Avanafil with Dapoxetine)

Introduction

Super Avana is a combined oral tablet that contains the phosphodiesterase-5 (PDE-5) inhibitor avanafil and the selective serotonin-reuptake inhibitor (SSRI) dapoxetine. The product is supplied as a 100 mg/60 mg pill and is intended for adult patients who require pharmacologic treatment for erectile dysfunction (ED) and, when indicated, premature ejaculation (PE). Avanafil is approved in many jurisdictions for the treatment of ED, while dapoxetine is approved in the European Union for PE. The combination seeks to address both conditions in a single dose, simplifying therapy for patients who experience both symptoms. Off-label use has been reported in clinical practice for conditions such as post-operative sexual dysfunction, but such applications are not approved by the U.S. Food and Drug Administration (FDA) or the European Medicines Agency (EMA).

What is Super Avana?

Super Avana is a fixed-dose combination tablet containing avanafil (100 mg) and dapoxetine (60 mg). Avanafil belongs to the PDE-5 inhibitor class, a group of drugs that facilitate penile erection by enhancing nitric-oxide-mediated vasodilation. Dapoxetine is a short-acting SSRI that increases the latency to ejaculation by modulating central serotonergic pathways. The product is manufactured by an undisclosed pharmaceutical company that markets the generic formulation worldwide.

“Super Avana is the generic version of well-known medications, containing the active compounds avanafil with dapoxetine. Our online pharmacy provides this generic alternative as a cost-effective treatment option. The combination is marketed under brand names such as Stendra (avanafil) and Priligy (dapoxetine) in various regions, which helps patients and clinicians recognize its therapeutic profile.”

How Super Avana Works

Avanafil (PDE-5 inhibition) - Avanafil binds selectively to the PDE-5 enzyme in the corpus cavernosum. By inhibiting PDE-5, it prevents the breakdown of cyclic guanosine monophosphate (cGMP), a second messenger that relaxes smooth muscle and enables increased blood flow during sexual arousal. The onset of action is typically within 15 minutes, and the effective window lasts up to 6 hours.

Dapoxetine (short-acting SSRI) - Dapoxetine blocks the reuptake of serotonin at neuronal synapses, raising central serotonin concentrations. Elevated serotonin prolongs the ejaculatory latency period. Because dapoxetine’s half-life is approximately 1-2 hours, its effect is limited to the period surrounding sexual activity, minimizing systemic exposure.

When combined, the two agents act on complementary pathways: avanafil restores the ability to achieve an erection, while dapoxetine extends the time to ejaculation, providing a coordinated approach for men who suffer from both ED and PE.

Conditions Treated with Super Avana

• Erectile Dysfunction (ED) - Avanafil is approved for the treatment of ED in adult males. It improves erectile response to sexual stimulation by enhancing penile blood flow. Clinical trials have demonstrated statistically significant improvements in International Index of Erectile Function (IIEF) scores compared with placebo.

• Premature Ejaculation (PE) - Dapoxetine is approved for the treatment of PE in the European Union. It increases intravaginal ejaculation latency time (IELT) and improves patient-reported control over ejaculation. Randomized, double-blind studies have shown a mean IELT increase of 2-3 minutes over baseline.

Super Avana therefore offers a single therapeutic option for men who experience both conditions concurrently, reducing pill burden and simplifying dosing schedules.

Off-Label and Investigational Uses of Super Avana

• Post-operative sexual dysfunction - Small case series have reported that avanafil improves erectile function after radical prostatectomy when administered early in the recovery period. The evidence is limited to observational data and has not received regulatory endorsement.

• Psychogenic erectile dysfunction co-existing with anxiety - Some clinicians have used the avanafil-dapoxetine combination to address anxiety-related performance issues, citing studies where short-acting SSRIs improved sexual confidence. These uses remain off-label and should be considered only under specialist supervision.

• Female sexual arousal disorder (FSAD) - Preliminary investigations have explored PDE-5 inhibitors in women with FSAD. Avanafil’s rapid onset makes it a candidate for such trials, but no definitive efficacy data exist.

All off-label applications lack formal approval from the FDA, EMA, or comparable agencies. Patients should discuss any non-approved use with a qualified healthcare provider, who can weigh potential benefits against uncertain safety profiles.

Is Super Avana the Right Medication for You?

Super Avana is most appropriate for adult men who:

1. Have a confirmed diagnosis of erectile dysfunction that responds to PDE-5 inhibition.
2. Experience clinically significant premature ejaculation, defined by an IELT of less than 1 minute or distress related to rapid ejaculation.
3. Prefer a single-pill regimen rather than separate medications for ED and PE.

Patients who should avoid Super Avana include:

• Individuals taking nitrates (e.g., nitroglycerin) or nitric-oxide donors, due to the risk of severe hypotension.
• Those with severe uncontrolled hypertension, recent myocardial infarction, or unstable heart disease.
• Patients with known hypersensitivity to avanafil, dapoxetine, or any excipients in the tablet.
• Men with severe hepatic impairment, as dapoxetine metabolism may be altered.

A thorough clinical assessment is essential to determine suitability.

Risks, Side Effects, and Interactions

Common

• Headache
• Flushing
• Nasal congestion
• Dizziness
• Gastrointestinal upset (nausea, dyspepsia)

These events are typically mild to moderate and resolve without intervention.

Rare

• Vision changes (color distortion, blurred vision)
• Priapism (prolonged erection lasting >4 hours)
• Mood alterations (anxiety, irritability)

Patients experiencing rare events should seek medical advice promptly.

Serious

• Severe hypotension, especially when combined with nitrates or alpha-blockers
• Cardiovascular events (myocardial infarction, stroke) in high-risk individuals
• Allergic reactions (rash, angioedema, anaphylaxis)

Immediate emergency care is required for serious adverse reactions.

Drug-Drug Interactions

• Nitrates (isosorbide dinitrate, nitroglycerin): additive vasodilatory effect → contraindicated.
• Alpha-blockers (tamsulosin, doxazosin): may cause marked blood pressure reduction → use with caution, adjust dosing.
• CYP3A4 inhibitors (ketoconazole, ritonavir): increase avanafil plasma levels → dose reduction may be necessary.
• CYP2D6 inhibitors (quinidine, fluoxetine): elevate dapoxetine concentrations → monitor for serotonin syndrome.

Food and Alcohol

• Avanafil can be taken with or without food; high-fat meals may delay onset by up to 30 minutes.
• Alcohol consumption should be moderate; excessive intake can exacerbate hypotension and dizziness.

Use: Dosing, Missed Dose, Overdose

Standard dosing - The recommended starting dose for most patients is one tablet (100 mg avanafil/60 mg dapoxetine) taken orally approximately 15 minutes before anticipated sexual activity. The tablet may be taken with or without food. No more than one dose per 24-hour period is advised.

Missed dose - If a dose is forgotten and sexual activity is still anticipated within the next hour, the tablet may be taken. If less than 15 minutes remain before activity, it is safer to skip the dose and resume the regular schedule the following day.

Overdose - In case of accidental ingestion of multiple tablets, the patient should seek immediate medical attention. Management is supportive, focusing on blood pressure monitoring, treating hypotension, and addressing any prolonged erection. Activated charcoal may be considered if presentation occurs within one hour of ingestion.

Practical precautions -

• Avoid operating heavy machinery or driving until the full effects of the medication are known, especially if dizziness occurs.
• Do not combine with recreational drugs that affect vascular tone or serotonin pathways (e.g., poppers, MDMA).
• Store tablets at room temperature, away from moisture and direct sunlight.

FAQ

• What is the onset time for avanafil in Super Avana? The avanafil component typically begins to work within 15 minutes after ingestion. Peak plasma concentrations are reached at about 30 minutes, providing a rapid therapeutic window for sexual activity.

• Can Super Avana be taken with a high-fat meal? Yes, the tablet can be taken with food. A high-fat meal may delay the onset of action by up to 30 minutes, but the overall efficacy remains unchanged.

• Does dapoxetine cause daytime drowsiness? Dapoxetine’s short half-life minimizes daytime sedation. Most patients report mild, transient fatigue that usually resolves within a few hours after the dose.

• Is a prescription required to purchase Super Avana online? The purchase process generally involves a legitimate prescription, as the medication is regulated in most countries. Our online pharmacy facilitates the procurement of a valid prescription from a qualified prescriber before dispensing.

• How should Super Avana be stored in a humid climate? Tablets should be kept in a dry, airtight container, away from excessive humidity. If stored in a humid environment, placing a desiccant packet in the container can maintain stability.

• What are the visible characteristics of the Super Avana tablet? The tablet is oval, blue-colored, and imprinted with “100/60” on one side to denote the avanafil (100 mg) and dapoxetine (60 mg) contents. Inactive ingredients include lactose, microcrystalline cellulose, and magnesium stearate.

• Can Super Avana be used by men with a history of mild hypertension? Patients with controlled mild hypertension may use Super Avana, but blood pressure should be monitored closely, especially when initiating therapy. The combined vasodilatory effect of avanafil may lower blood pressure modestly.

• Does dapoxetine affect drug testing for serotonin reuptake inhibitors? Standard drug panels typically do not detect dapoxetine, as it is a short-acting SSRI. However, specialized testing can identify its metabolites if required.

• Is travel with Super Avana permitted across international borders? When traveling, patients should carry the medication in its original packaging with a copy of the prescription. Some countries require additional documentation; checking local regulations before travel is advisable.

• What is the difference between Super Avana and taking avanafil and dapoxetine separately? The combination tablet offers synchronized dosing, reducing pill burden and ensuring optimal timing of both agents. Separate dosing may lead to timing mismatches, whereas the fixed-dose combination guarantees coordinated pharmacologic action.

Glossary

Phosphodiesterase-5 (PDE-5) inhibitor

A class of drugs that block the PDE-5 enzyme, increasing cGMP levels and promoting smooth-muscle relaxation in the penis, thereby facilitating erection.

Intravaginal Ejaculation Latency Time (IELT)

The measured time interval from the start of vaginal penetration to ejaculation; used as an objective endpoint in premature ejaculation studies.

Serotonin syndrome

A potentially life-threatening condition resulting from excessive serotonergic activity, characterized by agitation, hyperthermia, tremor, and autonomic instability.

Buying Super Avana from Our Online Pharmacy

Super Avana can be obtained through our online pharmacy, which specializes in delivering quality-assured generic medications to patients worldwide. Our service provides:

• Cost-effective pricing - The generic formulation is offered at a price close to the manufacturer’s production cost, making it more affordable than many brand-name alternatives.
• Verified quality - All tablets are sourced from licensed, GMP-certified suppliers, ensuring consistency with international pharmacopeial standards.
• Discreet, reliable delivery - Packages are shipped in unmarked envelopes, with standard express delivery in 7 days or regular airmail in approximately 3 weeks, depending on location.
• Privacy-focused handling - As a pharmacy broker service, we work with overseas licensed pharmacies while safeguarding patient confidentiality throughout the ordering and fulfillment process.

By choosing our online pharmacy, patients who face limited access through conventional pharmacies or insurance formularies can obtain Super Avana in a secure, affordable, and private manner.

Disclaimer

The information presented about Super Avana is intended solely for general educational purposes and does not substitute for professional medical advice. Treatment decisions, including those involving off-label applications, must be made under the guidance of a qualified healthcare professional. Readers are presumed to be competent adults capable of making informed health decisions. Our online pharmacy supplies Super Avana to individuals who may encounter restricted availability via traditional pharmacy channels, insurance-based prescription programs, or who seek more affordable generic alternatives. Always consult a qualified healthcare provider before initiating, modifying, or discontinuing any medication.