Generic Stugeron (Cinnarizine)

Introduction

Stugeron is a prescription tablet that contains the antihistamine-type drug cinnarizine. It is supplied in a 25 mg dose and belongs to the class of calcium-channel-blocking antihistamines. The primary, regulatory-approved use of Stugeron is the relief of vertigo and balance disorders associated with Ménière’s disease and other vestibular conditions. In addition, cinnarizine has documented activity against motion-sickness and peripheral vascular complaints, which are sometimes noted in clinical practice.

What is Stugeron?

Stugeron is the brand name for a tablet formulation that delivers 25 mg of the active compound cinnarizine. Cinnarizine was first synthesized in the s and introduced in Europe as an antihistamine with pronounced vestibular-stabilising properties. The drug is marketed under several well-known brand names, including Stugeron, Dithiaden, and Stugeron® (different regional trademarks). It is manufactured by pharmaceutical companies that hold marketing authorisation in the respective territories; the exact manufacturer may vary by country.

How Stugeron Works

Cinnarizine blocks voltage-dependent calcium channels in inner-ear hair cells and vascular smooth muscle. By reducing calcium influx, it dampens the abnormal firing of vestibular nerve endings that cause vertigo. The drug also antagonises histamine H1 receptors, which contributes to its anti-nausea effect during motion. The combined calcium-channel blockade and antihistaminic action lead to improved equilibrium and a reduction in the sensation of spinning. Typical onset of symptom relief occurs within 30-60 minutes after oral intake, and the therapeutic effect lasts for 8-12 hours, matching the half-life of cinnarizine (≈10 hours).

Conditions Treated with Stugeron

• Ménière’s disease - episodic vertigo, tinnitus, and fluctuating hearing loss; cinnarizine reduces the frequency and intensity of attacks.
• Benign paroxysmal positional vertigo (BPPV) adjunct - while canalith repositioning maneuvers remain first-line, Stugeron may be added to control residual dizziness.
• Motion-sickness - prophylactic use before travel (car, boat, aircraft) diminishes nausea and disorientation.

The drug is effective in these indications because vestibular hyper-excitability and inner-ear vascular dysregulation are central to the pathophysiology, both of which are moderated by calcium-channel inhibition.

Off-Label and Investigational Uses of Stugeron

• Peripheral vascular disease (PVD) and Raynaud’s phenomenon - small clinical series have reported improvement in microcirculatory flow after cinnarizine therapy. The evidence is limited and not approved by regulatory agencies.
• Migraine prophylaxis - certain trials suggest that calcium-channel blockers migraine frequency; cinnarizine has been explored as an alternative, but robust data are lacking.
• Chronic tinnitus - observational reports indicate possible symptom relief, yet the mechanism remains speculative and formal approval is absent.

These applications are not sanctioned by the FDA, EMA, or other major regulators. Patients should only consider such uses under the direct supervision of a qualified healthcare provider, with full awareness of the uncertain risk-benefit profile.

Is Stugeron the Right Medication for You?

Stugeron is appropriate for adults who experience recurrent vertigo linked to Ménière’s disease, BPPV-related residual dizziness, or predictable motion-induced nausea. It is especially useful when non-pharmacologic measures (dietary salt restriction, vestibular rehabilitation) have not fully controlled symptoms.

Contra-indications include:

• Known hypersensitivity to cinnarizine or any excipients.
• Severe hepatic impairment (cinnarizine is metabolised hepatically).
• Concomitant use of potent CYP3A4 inhibitors (e.g., ketoconazole) that could raise plasma levels.

Pregnant or breastfeeding individuals should avoid Stugeron unless the potential benefit justifies the potential risk, as safety data are insufficient.

Risks, Side Effects, and Interactions

Common

• Drowsiness or mild sedation.
• Dry mouth.
• Gastro-intestinal discomfort (nausea, abdominal pain).

These effects are usually transient and resolve with continued therapy or dose adjustment.

Rare

• Weight gain (particularly with prolonged use).
• Extrapyramidal symptoms such as tremor or rigidity, reported chiefly in elderly patients.

Monitoring is advised when therapy extends beyond several weeks.

Serious

• Extrapyramidal syndrome progressing to drug-induced Parkinsonism; clinicians should discontinue the drug immediately if rigidity, bradykinesia, or postural instability develop.
• Severe hepatic dysfunction manifested by jaundice or elevatedaminases; liver function tests are recommended before initiating long-term therapy.

Drug-Drug Interactions

• CYP3A4 inhibitors (e.g., erythromycin, clarithromycin) may increase cinnarizine plasma concentrations, heightening the risk of sedation and extrapyramidal effects.
• Central nervous system depressants (benzodiazepines, opioids) can potentiate drowsiness.
• Anticholinergic agents may exacerbate dry mouth.

Drug-Food Interactions

• Heavy, fatty meals can delay absorption but do not alter overall exposure; taking the tablet with a light snack may reduce gastrointestinal irritation.
• Alcohol intensifies drowsiness and should be avoided while on Stugeron.

Use: Dosing, Missed Dose, Overdose

Standard dosing for adult vertigo is one 25 mg tablet taken orally once daily, preferably in the evening to minimise daytime somnolence. For motion-sickness prophylaxis, a single 25 mg dose can be taken 30 minutes before travel; additional doses may be administered at 8-hour intervals if required, not exceeding three tablets in 24 hours.

If a dose is missed, take it as soon as remembered unless the next scheduled dose is within 4 hours; in that case, skip the missed dose and resume the regular schedule. Do not double-dose to compensate.

Overdose symptoms may include profound drowsiness, hypotension, and extrapyramidal signs. Management is supportive: monitor vital signs, ensure airway protection, and consider activated charcoal if presentation is within one hour of ingestion. Seek emergency medical care promptly.

Precautions:

• Avoid operating heavy machinery or driving until you know how Stugeron affects you.
• Do not consume alcohol while taking the medication.
• Store tablets below 30 °C, in a dry place, out of of children.

FAQ

• Can Stugeron be taken with food?

  • Yes. Taking the tablet with a light meal can lessen stomach upset, though absorption is not markedly affected by food.

• How long does it take for Stugeron to start working for motion-sickness?

  • Clinical onset of relief within 30-60 minutes after ingestion, making it suitable for short-notice travel plans.

• What should I do if I feel unusually drowsy after a dose?

  • Reduce activities that require full alertness (driving, operating machinery) until the sedative effect subsides; if drowsiness persists, discuss dose timing with a healthcare professional.

• there a risk of developing dependence on Stugeron?

  • Cinnarizine does not produce chemical dependence. However, long-term use may lead to tolerance of drowsiness, so periodic evaluation is advisable.

• Can Stugeron be used by older adults?

  • It be prescribed to seniors, but they have a higher susceptibility to extrapyramidal side effects; careful monitoring is recommended.

• What are the visual side effects, if any?

  • Rarely, patients report blurred vision or difficulty focusing, usually linked to anticholinergic activity; these symptoms typically resolve after discontinuation.

• Does Stugeron interact with common over-the-counter antihistamines?

  • Concurrent antihistamines may amplify sedation and dry-mouth effects; timing doses several hours apart can mitigate the interaction.

• How should Stugeron be stored during summer travel?

  • Keep the tablets in a temperature-controlled container, away from direct sunlight and humidity; a small insulated pouch works well for short trips.

• Is Stugeron safe for people with high blood pressure?

  • Cinnarizine can cause mild vasodilation, which may lower blood pressure slightly; patients on antihypertensive therapy should monitor blood pressure regularly.

• Can I take Stugeron if I have a history of epilepsy?

  • There is limited evidence of seizure risk, but caution is advised; discuss any history of seizures with a qualified professional before use.

Glossary

Calcium-channel blocker

A drug that inhibits the flow calcium ions through cellular channels, reducing muscle contraction and neuronal excitability.

Vestibular system

The inner-ear network that detects head movement and orientation, essential for balance and spatial perception.

Extrapyramidal symptoms

Movement disorders such as tremor, rigidity, or bradykinesia that arise from interference with dopamine pathways in the brain.

Hepatic metabolism

The process by which the liver chemically modifies a drug, usually making it easier to eliminate from the body.

Buying Stugeron from Our Online Pharmacy

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By operating as a pharmacy-broker service, we collaborate with accredited overseas pharmacies to bring essential medicines like Stugeron to patients worldwide, especially where local availability is limited. This model combines convenience with rigorous standards, helping you maintain uninterrupted treatment without compromising safety.

Disclaimer

The information presented about Stugeron is intended for general educational purposes and does not substitute professional medical advice. Treatment choices, including any off-label applications, must be made under the guidance of a qualified healthcare professional. Readers are assumed to be competent adults capable of evaluating health information responsibly. Our online pharmacy provides access to Stugeron for individuals who may encounter limited supply through conventional channels or who are searching for affordable generic options. Always discuss any medication changes with a qualified health provider before initiating, modifying, or stopping therapy.