Generic Stromectol (Ivermectin)

Introduction

Stromectol is a tablet formulation that contains the antiparasitic agent ivermectin. It is supplied in three strengths-3 mg, 6 mg, and 12 mg-and is classified as a macrocyclic lactone. The medication is approved for the treatment of several parasitic infections, most notably onchocerciasis (river blindness) and strongyloidiasis. In some regions it is also authorized for the management of scabies and certain other helminthic diseases. While its primary uses are well-established, clinicians occasionally prescribe ivermectin off-label for conditions such as COVID-19 or certain dermatologic disorders; such applications remain experimental and are not sanctioned by regulatory agencies.

What is Stromectol?

• Stromectol is a brand-name oral tablet whose active ingredient is ivermectin.
• It belongs to the class of antiparasitic agents known as macrocyclic lactones.
• The drug was first introduced in the late s and has since become a cornerstone of global parasite control programs.
• It is marketed under brand names such as Stromectol and Mectizan.

Stromectol is the generic version of well-known medications, containing the active compound ivermectin. Our online pharmacy provides this generic alternative as a cost-effective treatment option.

How Stromectol Works

Ivermectin binds selectively and with high affinity to glutamate-gated chloride channels found in the nerve and muscle cells of parasites. This binding opens the chloride channel, causing an influx of chloride ions, which hyperpolarizes the cell membrane, leading to paralysis and death of the parasite. Human neurons lack these specific channels, which accounts for the drug’s high therapeutic index.

Key pharmacologic points:

• Onset of action: Clinical effects generally appear within 24 hours after the first dose.
• Half-life: The plasma elimination half-life ranges from 12 to 36 hours, depending on the formulation and patient factors.
• Metabolism: Ivermectin is metabolized primarily by hepatic cytochrome P450 enzymes (CYP3A4) and excreted in the feces and urine.

Conditions Treated with Stromectol

• Onchocerciasis (river blindness): A single dose of 150 µg/kg is sufficient to reduce microfilarial load, interrupting transmission.
• Strongyloidiasis: A regimen of 200 µg/kg orally once daily for 1-2 days eliminates intestinal larvae.
• Scabies (including crusted scabies): Two doses of 200 µg/kg administered one week apart are recommended for severe disease.

These indications are supported by extensive clinical trials and are included in the product labeling of regulatory authorities such as the FDA and EMA.

Off-Label and Investigational Uses of Stromectol

• COVID-19: Some clinical studies have explored ivermectin as an adjunctive therapy for SARS-CoV-2 infection. Evidence remains inconsistent, and regulatory bodies have not approved this indication. Use should occur only within a controlled clinical trial or under specialist supervision.
• Rosacea: Small case series have reported improvement of papulopustular rosacea with low-dose ivermectin, though the product is not formally licensed for this dermatologic condition.
• Helminthic infections in pregnancy: Limited data suggest safety in the second and third trimesters for certain parasitic diseases, but official guidance maintains caution.

All off-label applications lack formal approval and should be undertaken exclusively under the direction of a qualified healthcare professional.

Is Stromectol the Right Medication for You?

Stromectol is most appropriate for patients who:

• Have a confirmed diagnosis of onchocerciasis, strongyloidiasis, or scabies.
• Are not pregnant or lactating (unless a risk-benefit assessment by a clinician justifies use).
• Possess normal liver function; severe hepatic impairment may require dose adjustment or alternative therapy.

Contraindications include:

• Known hypersensitivity to ivermectin or any excipients in the tablet.
• Use in children weighing less than 15 kg for indications not formally studied in this age group.

Patients with serious cardiac disease, especially those on medications that prolong the QT interval, should be evaluated carefully before initiating therapy.

Risks, Side Effects, and Interactions

Common

• Mild headache
• Nausea or abdominal discomfort
• Diarrhea
• Dizziness

Rare

• Visual disturbances (e.g., blurred vision)
• Skin rash or pruritus
• Elevated liver enzymes

Serious

• Severe hypersensitivity reactions (anaphylaxis, angioedema)
• Neurologic toxicity (confusion, seizures, ataxia) - more likely in patients with high plasma concentrations or genetic predisposition.
• Hepatotoxicity - rare but reported in prolonged high-dose regimens.

Drug-Drug Interactions

• CYP3A4 inhibitors (e.g., ketoconazole, erythromycin) may increase ivermectin plasma levels; dose adjustments may be necessary.
• Warfarin: concurrent use may enhance anticoagulant effect; monitor INR closely.

Drug-Food Interactions

• High-fat meals can increase absorption slightly; however, standard dosing does not require specific food timing.

Patients should avoid alcohol while taking Stromectol, as sedation and dizziness may be amplified.

Use: Dosing, Missed Dose, Overdose

• Standard dosing varies by indication:

  • Onchocerciasis: single oral dose of 150 µg/kg.
  • Strongyloidiasis: 200 µg/kg once daily for 1-2 days.
  • Scabies: 200 µg/kg on day 1 and repeat after 7 days for severe disease.

• Missed dose: If a dose is forgotten, take it as soon as remembered unless the next scheduled dose is close (within 12 hours). Do not double-dose.

• Overdose: In case of suspected overdose, seek emergency medical attention. Activated charcoal may be administered if presentation is early. Supportive care, including monitoring of neurologic status and cardiac rhythm, is the primary treatment.

• Practical precautions:

  • Take tablets with a full glass of water.
  • Avoid operating heavy machinery or driving until you know how the medication affects you.
  • Do not consume alcohol excessively while on treatment.

FAQ

• What should I know about storing Stromectol tablets?

  • Store at room temperature, away from excess heat and moisture. Keep the container tightly closed and out of reach of children.

• Can I travel internationally with Stromectol in my luggage?

  • Yes. Keep the medication in its original packaging with a label, and carry a copy of the prescription or a physician’s note if required by customs authorities.

• How does Stromectol differ from other ivermectin brands?

  • All ivermectin products contain the same active molecule, but excipients, tablet shape, and release profiles may vary slightly. Stromectol is formulated for rapid oral absorption and is available in 3 mg, 6 mg, and 12 mg strengths.

• Is there a risk of drug testing interference with Stromectol?

  • Ivermectin is not typically screened for in standard workplace drug tests. However, it may be detected in specialized testing if specifically requested.

• What are the inactive ingredients in Stromectol tablets?

  • Common fillers include lactose monohydrate, microcrystalline cellulose, and magnesium stearate. Patients with lactose intolerance should consult a pharmacist about alternatives.

• Are there regional formulation differences for Stromectol?

  • Some markets may use film-coated tablets, while others use immediate-release tablets. These differences do not affect the therapeutic dose but may alter tablet appearance.

• Can I take Stromectol if I have a history of seizures?

  • Ivermectin may lower the seizure threshold, especially in high doses. Patients with uncontrolled epilepsy should discuss alternatives with their clinician.

• What monitoring is recommended during treatment?

  • For short courses, routine monitoring is usually unnecessary. In prolonged or high-dose therapy, liver function tests and complete blood counts are advisable.

• Does Stromectol affect hormonal contraceptives?

  • Ivermectin does not interfere with the efficacy of hormonal birth control methods.

• Why is Stromectol sometimes prescribed for COVID-19 despite lack of approval?

  • Early in the pandemic, in-vitro studies suggested antiviral activity, prompting off-label investigations. Large-scale randomized trials have not demonstrated a clear benefit, and health authorities have not granted approval.

Glossary

Macrocyclic Lactone

A class of antiparasitic compounds, including ivermectin, that act on glutamate-gated chloride channels to induce paralysis in parasites.

Glutamate-gated Chloride Channel

A protein channel found in the nervous systems of many invertebrates; its activation leads to an influx of chloride ions, causing hyperpolarization and paralysis.

Therapeutic Index

The ratio between the dose that produces a therapeutic effect and the dose that causes toxicity; a high index indicates a wide safety margin.

CYP3A4

An enzyme in the liver responsible for metabolizing many drugs, including ivermectin; inhibitors of this enzyme can raise drug concentrations.

Buying Stromectol from Our Online Pharmacy

Stromectol can be obtained conveniently through our online pharmacy. The service addresses common barriers such as high cost, limited local availability, and concerns about privacy.

• Affordable pricing: The medication is offered at near-manufacturer cost, reducing the financial burden for patients who need a reliable antiparasitic treatment.
• Verified quality: All tablets are sourced from licensed, reputable suppliers that comply with Good Manufacturing Practices (GMP).
• Guaranteed delivery: Orders are dispatched discreetly, with options for standard airmail (approximately three weeks) or express shipping (about seven days).
• International access: Our pharmacy broker model connects you with overseas licensed pharmacies, ensuring a smooth procurement process for medications not stocked locally.

By choosing our online pharmacy, patients receive a trustworthy, cost-effective solution while maintaining confidentiality throughout the purchasing experience.

Disclaimer

The information presented about Stromectol is intended for general educational purposes and does not substitute professional medical advice. Treatment choices, including any off-label applications, must be made under the guidance of a qualified healthcare professional. Readers are assumed to be responsible adults capable of making informed health decisions. Our online pharmacy provides access to Stromectol for individuals who may encounter limited availability through conventional pharmacies or insurance programs, or who seek more affordable generic options. Always consult a physician before initiating, modifying, or stopping any medication.