Intagra (Sildenafil Citrate)

Introduction

Intagra is a tablet that contains the active ingredient sildenafil citrate, supplied in a 100 mg dose. Sildenafil citrate belongs to the phosphodiesterase-5 (PDE5) inhibitor class and is primarily used to treat erectile dysfunction (ED). The medication is manufactured by a licensed pharmaceutical company (specific manufacturer details are not In addition to its approved use for ED, sildenafil citrate is also approved in separate formulations for pulmonary arterial hypertension (PAH) under the brand name Revatio. Off-label, clinicians sometimes consider sildenafil for conditions such as high-altitude pulmonary edema or certain cases of Raynaud’s phenomenon, but these uses have not received regulatory approval.

What is Intagra?

Intagra is a generic tablet that delivers 100 mg of sildenafil citrate. It is the same active molecule found in well-known marketed products such as Viagra and Revatio, providing a cost-effective alternative to brand-name therapies. Our online pharmacy supplies this generic version, ensuring that patients receive a therapeutically equivalent product at a reduced price.

How Intagra Works

Sildenafil citrate selectively inhibits the enzyme phosphodiesterase-5, which normally degrades cyclic guanosine monophosphate (cGMP) in smooth-muscle cells. By blocking PDE5, cGMP levels rise, leading to relaxation of smooth muscle in the corpus cavernosum of the penis and in theculature.

• Erectile dysfunction: Elevated cGMP allows arterial inflow to increase during sexual stimulation, resulting in an erection sufficient for intercourse.
• Pulmonary arterial hypertension: Relaxation of pulmonary arterial smooth muscle reduces vascular resistance, improving exercise capacity and hemodynamics.

Onset of action typically occurs within 30-60 minutes after oral ingestion. Peak plasma concentrations are reached in about one hour, and the pharmacologic effect can last up to 4-6 hours. Sildenafil is metabolized primarily by the hepatic CYP3A4 enzyme and eliminated via urine and feces, with a terminal half-life of roughly 4 hours.

Conditions Treated with Intagra

• Erectile Dysfunction (ED): The approved indication in most jurisdictions. Sildenafil improves erectile response in men with vascular or neurogenic etiologies of ED.
• Pulmonary Arterial Hypertension (PAH): In the specific20 mg formulation (Revatio) it is approved for PAH; the 100 mg tablet is not formally indicated for PAH but shares the same pharmacologic profile.

Intagra is effective for these conditions because the underlying pathology involves excessive PDE5 activity, which reduces cGMP-mediated smooth-muscle relaxation. By inhibiting PDE5, the drug restores normal vasodilatory signaling.

Off-Label and Investigational Uses of Intagra

• High-Altitude Pulmonary Edema (HAPE): Small clinical studies have shown that sildenafil can reduce pulmonary artery pressure in climbers, potentially mitigating HAPE risk. Evidence remains limited, and the therapy is not approved for this indication.
• Raynaud’s Phenomenon: Case series suggest benefit from sildenafil in severe, refractory digital vasospasm, but randomized controlled data are lacking.
• Benign Prostatic Hyperplasia (BPH)-related Lower Urinary Tract Symptoms: Limited trials indicate modest improvement in urinary flow rates, though the mechanism is not fully understood.

These uses are not authorized by the FDA, EMA, or comparable agencies. Patients should only consider off-label applications under direct supervision of a qualified healthcare professional, after a thorough risk-benefit discussion.

Is Intagra the Right Medication for You?

Intagra is appropriate for adult men who experience difficulty achieving or maintaining an erection sufficient for sexual activity and who have no contraindications to PDE5 inhibition. It is also suitable for patients who have been prescribed sildenafil for PAH in the approved low-dose formulation, provided the prescribing clinician selects the correct dose.

Contraindications and cautions include:

• Concomitant use of nitrates (e.g., nitroglycerin) or nitric-oxide donors, which can cause profound hypotension.
• hypertension or recent cardiovascular events (myocardial infarction, stroke).
• Known hypersensitivity to sildenafil or any tablet excipients.
• Severe hepatic impairment (Child-Pugh C) or end-stage renal disease (requiring dialysis).

Patients with these conditions should discuss alternative therapies with their clinician.

Risks, Side Effects, and Interactions

Common

• Headache
• Flushing
• Nasal congestion
• Dyspepsia (indigestion)
• Visual disturbances (e.g., blue-tinted vision)

Rare

• Myalgia or back pain (usually transient)

• Priapism (prolonged erection lasting > 4 hours)

• Hearing loss or sudden decrease in hearing acuity### Serious

• Severe hypotension, with nitrates or alpha-blockers

• Cardiovascular events (myocardial infarction, arrhythmia) in high-risk patients

• Vision loss secondary to non-arteritic anterior ischemic optic neuropathy (NAION)

Drug-Drug Interactions

• Nitrates (isosorbide dinitrate, nitroglycerin) → life-threatening hypotension
• Alpha-blockers (tamsulosin, doxazosin) → additive blood pressure lowering; start with low sildenafil dose and monitor
• CYP3A4 inhibitors (ketoconazole, itraconazole, ritonavir) → increase sildenafil plasma levels; dose reduction may be required
• CYP3A4 inducers (rifampin, carbamazepine) → reduce sildenafil exposure; efficacy may be diminished

Drug-Food Interactions

• High-fat meals can delay absorption, reducing onset speed by up to 1 hour. Patients seeking rapid effect should take the tablet on an empty stomach.

Use: Dosing, Missed Dose, Overdose

• Standard dosing for ED: Start with 50 mg taken as needed about 1 hour before sexual activity. Depending on efficacy and tolerability, the dose may be increased to 100 mg or decreased to 25 mg. No more than one tablet per 24 hours.
• Missed dose: Because sildenafil is taken only when sexual activity is anticipated, a missed dose does not require ‘make-up’. If a dose is taken inadvertently early, wait at least 24 hours before the next tablet.
• Overdose: Symptoms may include severe hypotension, fainting, prolonged erection, or chest pain. If overdose is suspected, seek immediate medical attention; supportive measures (intravenous fluids, vasopressors) are the mainstay of treatment.

Practical precautions

• Avoid excessive alcohol, which can exacerbate hypotension and dizziness.

• Do not combine with recreational “poppers” (nitrites) for the same reason.

• Refrain from operating heavy machinery or driving until the individual knows how sildenafil affects them, particularly if dizziness occurs.- What should I do with Intagra if I travel internationally?

  • Store the tablets in their original container at room temperature, protected from moisture and heat. Carry a copy of the prescription (or a pharmacist-approved medication record) to avoid customs delays.

• Can I take Intagra with my antihypertensive medication?

  • Most blood-pressure drugs are safe with sildenafil, but alpha-blockers and certain vasodilators can cause additive drops in blood pressure. Discuss dosage adjustments with your clinician.

• How does the appearance of Intagra tablets differ from brand-name Viagra?

  • Intagra tablets are typically round, film-coated, and may be white or off-white with a “100 mg” imprinted. Brand-name Viagra tablets are usually blue, diamond-shaped, and bear the “Viagra” logo.

• Are there any sugar or gluten ingredients in Intagra?

  • The inactive ingredients commonly include microcrystalline cellulose, croscarmellose sodium, magnesium stearate, and titanium dioxide. Neither sugar nor gluten-containing excipients are listed, but patients with severe allergies should verify the full excipient list with the supplier.

• Will taking Intagra affect drug testing for employment?

  • Sildenafil is not a controlled substance and does not appear on standard workplace drug screens. However, specialized testing for erectile-dysfunction medications exists; employees should check employer policies.

• Is it safe to use Intagra after a recent myocardial infarction?

  • Patients who have suffered a heart attack within the past 6 months are generally advised against sexual activity that could stress the cardiovascular system, and sildenafil may increase that risk. A cardiology evaluation is essential before use.

• How does sildenafil compare with older ED drugs like alprostadil?

  • Sildenafil acts systemically by enhancing nitric-oxide signaling, whereas alprostadil is a prostaglandin analog delivered intra-urethrally or intracavernosally. Sildenafil offers oral convenience, but alprostadil may be preferable in men who cannot tolerate oral PDE5 inhibitors.

• What is the impact of severe liver disease on Intagra dosing?

  • Hepatic impairment reduces sildenafil clearance, leading to higher plasma concentrations. In Child-Pugh class B or C liver disease, the dose should be reduced to 25 mg, and careful monitoring is required.

• Can I take Intagra daily as a preventive measure?

  • Sildenafil is approved for use as needed for ED, not for daily prophylaxis. Daily dosing is only studied in low-dose formulations for pulmonary hypertension. Routine daily use for erectile function lacks evidence and may increase side-effect risk.

• Why does Intagra sometimes cause a blue tint to my vision?

  • Sildenafil can transiently affect retinal phosphodiesterase enzymes, altering colour perception. The effect is usually reversible within a few hours and does not indicate permanent visual damage.

Glossary

Phosphodiesterase-5 (PDE5) Inhibitor

A class of drugs that block the PDE5 enzyme, preventing breakdown of cGMP and promoting smooth-muscle relaxation in specific tissues.

cGMP (Cyclic Guanosine Monophosphate)

A second messenger molecule that mediatesodilation; its concentration rises when PDE5 is inhibited.

Priapism

A prolonged, painful erection lasting more than 4 hours; it requires urgent medical attention to prevent tissue damage.

Buying Intagra from Our Online Pharmacy

Intagra can be obtained through our online pharmacy, which operates as a licensed pharmacy-broker service partnering with reputable overseas suppliers. This model enables us to source the medication at near-manufacturer cost, providing patients with a cost-effective option without sacrificing quality.

All tablets are sourced from, GMP-certified manufacturers and undergo strict quality-control checks before dispatch. Our fulfillment process includes discreet packaging and reliable shipping methods: express deliveries typically arrive within 7 days, while standard airmail may take up to 3 weeks, depending on destination.

Patients who face limited availability in local pharmacies, lack insurance coverage, or seek a more affordable generic alternative benefit from. We prioritize privacy, ensuring that personal information is protected throughout the ordering and delivery stages.

By choosing our online pharmacy, you gain access to a professionally handled, affordable, and confidential solution for obtaining Intagra.

Disclaimer

The information presented about Intagra is intended for general educational purposes only and does not substitute for professional medical advice. Treatment decisions, including any off-label applications, must be made under the supervision of a qualified healthcare provider. Readers are presumed to be responsible adults capable of making informed health choices. Our online pharmacy supplies Intagra to individuals who may encounter limited access through conventional pharmacies or insurance networks, or who are looking for affordable generic options. Always discuss with your clinician before initiating, adjusting, or discontinuing any medication.