Extra Super Avana (Avanafil with Dapoxetine )

Introduction

Extra Super Avana is a fixed-dose oral tablet that combines two pharmacologically active agents: avanafil, a selective phosphodiesterase-5 (PDE-5) inhibitor, and dapoxetine, a short-acting selective serotonin-reuptake inhibitor (SSRI). The product is supplied as a 200 mg/60 mg pill and is intended for adult patients who require pharmacotherapy for the co-occurrence of erectile dysfunction (ED) and premature ejaculation (PE). Both components have been approved separately in many jurisdictions-avanafil as the active ingredient of the brand Stendra, and dapoxetine as the active ingredient of the brand Priligy. The combination seeks to address two distinct aspects of male sexual function with a single dose, potentially simplifying treatment regimens.

What is Extra Super Avana?

Extra Super Avana is a combined tablet that delivers avanafil (200 mg) together with dapoxetine (60 mg).

• Classification: Combination drug; PDE-5 inhibitor + short-acting SSRI.
• Development history: Avanafil was first approved for ED in 2012 (FDA, EMA). Dapoxetine received approval for PE in 2009 (EMA) and later in several other markets. The rationale for a fixed-dose combination stems from clinical observations that many men experience both ED and PE, and that treating both conditions simultaneously can improve sexual satisfaction and adherence.
• Manufacturer: The precise commercial manufacturer of Extra Super Avana is not publicly disclosed; the product is marketed by a network of licensed overseas pharmacies that supply the tablet under this label.

Extra Super Avana is not a brand name for a single-entity molecule; it denotes the generic combination of avanafil and dapoxetine. The individual active agents are marketed under well-known brand names such as Stendra (avanafil) and Priligy (dapoxetine), which serve as useful reference points for patients seeking information.

How Extra Super Avana Works

Avanafil (PDE-5 inhibitor)

Avanafil selectively binds to the phosphodiesterase-5 enzyme in the corpus cavernosum. Inhibition of PDE-5 prevents the breakdown of cyclic guanosine monophosphate (cGMP), a second messenger that mediates smooth-muscle relaxation. Elevated cGMP levels allow nitric oxide-mediated vasodilation of penile arteries, leading to increased blood flow and erection when sexual stimulation is present. Avanafil has a rapid onset of action (as early as 15 minutes) and a half-life of approximately 5 hours, which contributes to its relatively short duration of effect compared with older PDE-5 inhibitors.

Dapoxetine (short-acting SSRI)

Dapoxetine blocks the reuptake of serotonin at the synaptic cleft, increasing serotonergic neurotransmission. This action shortens the ejaculatory latency time by modulating spinal reflex pathways that control ejaculation. Dapoxetine is distinguished from conventional SSRIs by its rapid absorption and a plasma half-life of roughly 1.5 hours, allowing on-demand dosing without the need for chronic administration.

Combined Effect

When taken together, avanafil facilitates erection while dapoxetine extends the time to ejaculation. The two mechanisms act on separate physiological pathways, which reduces the likelihood of pharmacodynamic interference. Clinical pharmacokinetic studies indicate that neither drug substantially alters the plasma concentration of the other when co-administered at the approved fixed dose.

Conditions Treated with Extra Super Avana

• Erectile Dysfunction (ED) - avanafil restores the ability to achieve and maintain an erection sufficient for sexual intercourse. It is approved for use in adult men with vascular, neurogenic, or mixed causes of ED.
• Premature Ejaculation (PE) - dapoxetine increases intravaginal ejaculatory latency time (IELT) and improves control over ejaculation. It is approved for men who experience ejaculation before or shortly after vaginal penetration on a frequent basis.

The combination is prescribed when both conditions are present, offering a single-pill solution that may improve treatment adherence and overall sexual satisfaction.

Off-Label and Investigational Uses of Extra Super Avana

• Psychogenic Erectile Dysfunction - Some clinicians have reported using avanafil in cases where anxiety or performance stress predominates, though regulatory approval is limited to organic or mixed-origin ED.
• Male Sexual Dysfunction Associated with Depression - Dapoxetine’s SSRI activity may modestly improve mood in patients with co-existing depressive symptoms, but dedicated antidepressant therapy remains the standard.
• Treatment of Ejaculatory Disorders in Post-Prostatectomy Patients - Small pilot studies suggest that short-acting SSRIs can aid in regaining ejaculatory control after nerve-sparing radical prostatectomy; however, formal approval for this indication does not exist.

All off-label uses should only be undertaken under direct supervision of a qualified healthcare professional. Efficacy and safety for these indications have not been formally evaluated by regulatory agencies.

Is Extra Super Avana the Right Medication for You?

Suitable patient populations

• Adult men (≥ 18 years) diagnosed with both ED and PE, who prefer an “on-demand” treatment modality.
• Patients who have demonstrated tolerance to either component when used separately and have no contraindications listed below.

Clinical scenarios favoring use

• Men who find the logistics of taking two separate tablets cumbersome.
• Individuals who require rapid onset for spontaneous sexual activity, as avanafil’s effect can start within 15 minutes and dapoxetine is effective when taken 1-3 hours before intercourse.

Contraindications and cautions

• Concomitant use of nitrate medications (e.g., nitroglycerin) - risk of profound hypotension.
• Severe uncontrolled hypertension (systolic > 180 mm Hg or diastolic > 110 mm Hg).
• Known hypersensitivity to avanafil, dapoxetine, or any excipients in the tablet.
• Recent (≤ 24 hours) use of other PDE-5 inhibitors.
• History of severe hepatic impairment (Child-Pugh C) - dapoxetine metabolism may be compromised.
• Patients taking potent CYP3A4 inhibitors (e.g., ketoconazole, ritonavir) require dose adjustment or avoidance.

Risks, Side Effects, and Interactions

Common

• Headache
• Flushing
• Nasal congestion
• Dyspepsia (indigestion)
• Dizziness

These events are usually mild to moderate and tend to resolve without medical intervention.

Rare

• Vision changes (e.g., blue-tinted vision)
• Priapism (erection lasting > 4 hours)
• Hyponatremia (low blood sodium) associated with dapoxetine in susceptible individuals

Patients experiencing any of these should seek medical advice promptly.

Serious

• Cardiovascular events (myocardial infarction, stroke) in men with pre-existing heart disease.
• Severe hypotension, especially when combined with nitrates or alpha-blockers.
• Serotonin syndrome when dapoxetine is taken together with other serotonergic agents (e.g., tramadol, triptans).

If any serious reaction occurs, emergency medical care is warranted.

Drug-Drug Interactions

• Nitrates (e.g., isosorbide dinitrate) → profound hypotension.
• CYP3A4 inhibitors (ketoconazole, erythromycin, HIV protease inhibitors) → increased avanafil exposure.
• CYP2D6 inhibitors (quinidine, fluoxetine) → higher dapoxetine levels, raising risk of serotonin syndrome.
• Alcohol → may enhance vasodilatory effects and increase dizziness.

Drug-Food Interactions

• High-fat meals can delay avanafil absorption, modestly postponing onset.
• Grapefruit juice may increase avanafil plasma concentrations; avoid excessive consumption.

Use: Dosing, Missed Dose, Overdose

• Standard dosing: One tablet (200 mg avanafil + 60 mg dapoxetine) taken orally with water 1-3 hours before anticipated sexual activity. Do not exceed one tablet per 24 hours.
• Missed dose: Because the medication is taken “on demand,” a missed dose simply means the opportunity for intercourse was not used. Do not take a dose later in the same day to “make up” for a missed tablet.
• Overdose: Symptoms may include severe hypotension, syncope, prolonged erection, or excessive serotonin-related effects (agitation, tremor). Seek immediate medical attention; supportive care (fluid resuscitation, antihypertensives, or serotonin antagonists) is the mainstay.
• Administration tips:
  • Take with a full glass of water; food is allowed but a low-fat meal may speed onset.
  • Avoid alcohol excess, as it can amplify dizziness and hypotensive effects.
  • Do not operate heavy machinery or drive until you know how the medication affects you.

FAQ

• What should I do if I experience a painful erection lasting more than four hours?

  • Seek emergency medical care immediately. Prolonged erections (priapism) can cause permanent tissue damage if not treated promptly.

• Can I take Extra Super Avana if I have high blood pressure?

  • Controlled hypertension (≤ 140/90 mm Hg) is not an absolute contraindication, but you should discuss your cardiovascular status with a healthcare provider before initiating therapy.

• How does the combination affect sexual satisfaction compared with taking each drug separately?

  • Clinical studies suggest that treating both ED and PE concurrently can improve overall sexual satisfaction scores, but individual responses vary.

• Is it safe to travel internationally with Extra Super Avana?

  • The tablet is legal for personal use in most countries when declared at customs. Carry the medication in its original packaging with a copy of the prescription or a physician’s note if required.

• Will the tablet’s appearance differ between batches?

  • The standard tablet is round, blue-striped, and scored for easy division. In rare cases, manufacturers may use slightly different coloration; always verify the imprint code (e.g., “EA-200/60”) before use.

• Are there any differences in inactive ingredients that could cause allergies?

  • Inactive components may include lactose, microcrystalline cellulose, and magnesium stearate. Patients with known lactose intolerance or specific excipient allergies should confirm the formulation with the supplier.

• Can dapoxetine affect my mood or cause depression?

  • Dapoxetine is a short-acting SSRI and is not typically associated with mood worsening. However, rare cases of mood changes have been reported; report any persistent depressive symptoms to a clinician.

• Does alcohol consumption interfere with the drug’s effectiveness?

  • Moderate alcohol intake may reduce erectile response and increase dizziness, but it does not nullify the pharmacologic effect. Excessive drinking should be avoided.

• Is the medication detectable on standard drug tests?

  • Avanafil and dapoxetine are not usually screened for in routine occupational drug testing panels. Specialized testing would be required to detect them.

• What storage conditions are recommended for the tablets?

  • Store at 20-25 °C (68-77 °F) in a dry place, away from direct sunlight and moisture. Do not freeze.

• Can I use the medication if I am taking antihypertensive beta-blockers?

  • Beta-blockers do not interact directly with avanafil or dapoxetine, but combined vasodilatory effects may increase the risk of low blood pressure; monitor blood pressure closely.

Glossary

Phosphodiesterase-5 (PDE-5) inhibitor

A class of drugs that block the PDE-5 enzyme, leading to increased cGMP levels and enhanced penile blood flow during sexual stimulation.

Selective serotonin-reuptake inhibitor (SSRI)

A medication that inhibits the reabsorption of serotonin in the brain, increasing its availability and influencing mood and ejaculation latency.

Intravaginal Ejaculatory Latency Time (IELT)

The measured interval between vaginal penetration and ejaculation; a primary endpoint in premature ejaculation studies.

Serotonin syndrome

A potentially life-threatening condition caused by excessive serotonergic activity, presenting with agitation, hyperthermia, tremor, and autonomic instability.

Buying Extra Super Avana from Our Online Pharmacy

Extra Super Avana is available for purchase through our online pharmacy. We partner with licensed overseas suppliers that obtain directly from manufacturers adhering to Good Manufacturing Practices (GMP).

• Cost-effective pricing - Because we source the generic formulation at near-manufacturer rates, the price is substantially lower than many branded alternatives.
• Verified quality - Every batch is verified for potency, purity, and imprint accuracy before shipment, ensuring that you receive a product that meets international pharmacopeial standards.
• Discrete delivery - Orders are packaged in unmarked, tamper-evident envelopes and shipped via secure carriers. Standard airmail typically arrives within three weeks, while an express option is available with delivery in seven business days.
• Privacy-first service - We operate as a pharmacy-broker service, handling all communications and logistics while maintaining strict confidentiality of your personal information.

Patients who encounter limited access to this combination through local pharmacies or who face high out-of-pocket costs can rely on our platform to obtain a legitimate, affordable alternative without compromising safety.

Disclaimer

The information presented about Extra Super Avana is intended for general educational purposes only and does not substitute for professional medical advice. All therapeutic decisions, including any off-label considerations, must be made under the guidance of a qualified healthcare provider. Readers are presumed to be responsible adults capable of assessing health information critically. Our online pharmacy supplies Extra Super Avana for individuals who may experience restricted availability through conventional pharmacies or insurance-based dispensing, and who seek a cost-effective generic option. Always discuss with your clinician before starting, modifying, or discontinuing any medication.