Eriacta (Sildenafil Citrate)

Introduction

Eriacta is a tablet formulation that contains the active pharmaceutical ingredient Sildenafil Citrate, supplied in a 100 mg dose. It belongs to the class of phosphodiesterase-5 (PDE5) inhibitors and is primarily prescribed for the treatment of erectile dysfunction (ED). The medication is also approved for pulmonary arterial hypertension (PAH) under the same active compound, though at different dosing regimens. In addition to these primary indications, clinicians sometimes consider off-label applications such as Raynaud’s phenomenon or high-altitude adaptation, but these uses are not sanctioned by regulatory agencies.

What is Eriacta?

Eriacta is a brand-name tablet that delivers 100 mg of Sildenafil Citrate per pill. Sildenafil Citrate was originally developed by Pfizer and marketed under the well-known brand names Viagra® for erectile dysfunction and Revatio® for pulmonary arterial hypertension. Eriacta is manufactured by a licensed pharmaceutical company (specific manufacturer details are disclosed on the product label) and is classified as a prescription-only medication in most jurisdictions.

How Eriacta Works

Sildenafil Citrate selectively inhibits the enzyme phosphodiesterase-5 (PDE5) found in smooth muscle cells of the corpus cavernosum and pulmonary vasculature. By blocking PDE5, the drug prevents the breakdown of cyclic guanosine monophosphate (cG c). Elevated cG c levels lead to relaxation of smooth muscle, vasodilation, and increased blood flow to the penile tissue during sexual stimulation. In the pulmonary arteries, the same mechanism reduces vascular resistance, improving cardiac output and exercise capacity in patients with PAH.

Onset of action for erectile dysfunction typically occurs within 30-60 minutes after oral administration, with a therapeutic window of about 4-6 hours. The half-life of Sildenafil is approximately 4 hours, and it is eliminated primarily via hepatic metabolism (CYP3A4) and renal excretion.

Conditions Treated with Eriacta

• Erectile Dysfunction (ED): Sildenafil restores the physiological erectile response by enhancing nitric-oxide-mediated vasodilation. Randomized controlled trials (RCTs) have demonstrated significant improvements in the International Index of Erectile Function (IIEF) scores compared with placebo (Goldstein et al., JUrology, 1998).

• Pulmonary Arterial Hypertension (PAH): In PAH, chronic elevation of pulmonary arterial pressure leads to right-ventricular failure. Sildenafil improves exercise capacity and delays clinical worsening, as shown in the SUPER-1 trial (Galiè et al., NEJM, 2005). Although Eriacta’s approved dosage for PAH differs (typically 20 mg three times daily), the same active ingredient underpins its efficacy.

Off-Label and Investigational Uses of Eriacta

• Raynaud’s Phenomenon: Small clinical series suggest that low-dose Sildenafil may reduce frequency and severity of vasospastic attacks (Kass et al., Dermatology, 2011). Regulatory bodies have not approved this indication.

• High-Altitude Pulmonary Edema (HAPE) Prevention: A pilot study in Andean climbers reported modest protection against HAPE symptoms when Sildenafil was administered prophylactically (Schwartz et al., High Alt Med Biol, 2013).

• Heart Failure with Preserved Ejection Fraction (HFpEF): Ongoing Phase II trials are evaluating whether PDE5 inhibition improves exercise tolerance in HFpEF patients (Gupta et al., Circulation, 2022).

These applications remain experimental. Patients should only consider off-label use under direct supervision of a qualified healthcare professional, as safety and optimal dosing have not been formally established.

Is Eriacta the Right Medication for You?

Eriacta is suitable for adult men with a confirmed diagnosis of erectile dysfunction who have adequate cardiovascular health to tolerate sexual activity. It is also appropriate for patients with PAH who meet criteria for PDE5-inhibitor therapy.

Contraindications include:

• Concomitant use of nitrates (e.g., nitroglycerin) or nitric-oxide donors.
• Severe uncontrolled hypertension (systolic > 180 mm Hg or diastolic > 110 mm Hg).
• Known hypersensitivity to Sildenafil or any tablet excipients.
• Recent history of non-arteritic anterior ischemic optic neuropathy (NAION).

Patients with significant liver impairment, renal dysfunction (creatinine clearance < 30 mL/min), or a recent myocardial infarction should be evaluated carefully before initiating therapy.

Risks, Side Effects, and Interactions

Common

• Headache
• Flushing
• Dyspepsia (indigestion)
• Nasal congestion
• Visual disturbances (e.g., blue-tinted vision)

These effects are usually mild and transient, resolving without medical intervention.

Rare

• Priapism (persistent erection lasting > 4 hours) - requires urgent medical attention.
• Sudden hearing loss.
• Cardiovascular events (e.g., myocardial infarction) in predisposed individuals.

Serious

• Severe hypotension, particularly when combined with nitrates or potent alpha-blockers.
• Vision loss due to ischemic optic neuropathy.

Drug-Drug Interactions

• Nitrates (e.g., isosorbide dinitrate): Synergistic vasodilation can cause dangerous hypotension.
• Alpha-blockers (e.g., tamsulosin): May potentiate blood pressure lowering; start with a low dose of Eriacta and monitor.
• CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): Increase plasma concentrations of Sildenafil, raising the risk of adverse events.
• CYP3A4 inducers (e.g., rifampin, carbamazepine): May reduce drug efficacy.

Food and Lifestyle Interactions

• High-fat meals can delay absorption, extending time to onset by up to 2 hours.
• Excessive alcohol consumption may amplify hypotensive effects and increase the likelihood of dizziness.

Patients should avoid operating heavy machinery or driving until they understand how Eriacta affects them, especially during the first dose.

Use: Dosing, Missed Dose, Overdose

Standard Dosing for Erectile Dysfunction

• Start with one 100 mg tablet taken as needed, approximately 30-60 minutes before anticipated sexual activity.
• Do not exceed one dose per 24-hour period.
• If the 100 mg dose is not tolerated, a lower 50 mg tablet (if available) may be tried after consulting a clinician.

Pulmonary Arterial Hypertension (different formulation)

• Typical regimen: 20 mg three times daily, taken with food to improve absorption.

Missed Dose

• Eriacta is taken on an as-needed basis for ED; there is no scheduled daily dosing. If a dose is forgotten, take it only when sexual activity is anticipated. Do not double the dose to “make up” for a missed tablet.

Overdose

• Symptoms may include severe hypotension, prolonged erection, or chest discomfort.
• Seek immediate medical attention; treatment is supportive, with fluid resuscitation and blood pressure management as needed.

Practical Precautions

• Swallow tablets whole with a full glass of water.
• Food is not required, but a high-fat meal may delay effect.
• Avoid combining with recreational nitrates (e.g., poppers).
• Alcohol should be limited to reduce dizziness.

FAQ

• What should I do if I travel internationally with Eriacta?   Carry the medication in its original packaging with a copy of the prescription label. Keep the tablets in your carry-on luggage to avoid temperature extremes and ensure easy access during security screening.

• Can I store Eriacta in a humid climate?   Eriacta should be stored at a controlled room temperature (20 °C - 25 °C). In humid environments, keep the bottle tightly closed and consider a desiccant packet to protect against moisture absorption.

• What inactive ingredients are present in Eriacta tablets?   Typical excipients include lactose monohydrate, microcrystalline cellulose, magnesium stearate, and a film-coating polymer. Patients with lactose intolerance or specific excipient allergies should verify the full ingredient list on the product insert.

• How does Eriacta differ from other generic Sildenafil products?   All generics contain the same 100 mg dose of Sildenafil Citrate, but variations may exist in tablet shape, coating color, and inactive fillers. Bioequivalence studies mandated by regulatory agencies ensure therapeutic similarity.

• Is a urine drug test affected by Eriacta?   Sildenafil is not typically screened for in standard employment drug panels. However, specialized tests can detect it, though this is uncommon.

• Can Eriacta be used by men over 65 years old?   Age alone is not a contraindication, but older adults often have comorbidities and polypharmacy that increase the risk of interactions and hypotension. Dose adjustments and careful monitoring are advisable.

• Does Eriacta have any effect on fertility?   Current evidence indicates that Sildenafil does not impair sperm production or testosterone levels. It is considered neutral with respect to male fertility.

• Why does Eriaecta sometimes cause a blue-tinted vision?   Sildenafil can inhibit PDE6, an enzyme in retinal photoreceptors, leading to altered color perception (chromatopsia). The effect is usually transient and resolves when the drug plasma level declines.

• What is the legal status of importing Eriacta for personal use?   Importation rules vary by country. In many jurisdictions, bringing a personal supply for personal use is permitted if the medication is for a bona fide prescription and the quantity does not exceed a defined limit (often a 90-day supply). Always verify local customs regulations.

• How long does it take for a shipment of Eriacta to arrive?   Standard international airmail typically requires 2-4 weeks, while express courier services can deliver within 5-7 days, depending on the destination and customs processing.

Glossary

Phosphodiesterase-5 (PDE5) Inhibitor

A class of drugs that block the PDE5 enzyme, preventing the breakdown of cG c and promoting smooth-muscle relaxation and vasodilation.

cG c (Cyclic Guanosine Monophosphate)

A secondary messenger molecule that mediates relaxation of smooth muscle cells in response to nitric oxide.

Pulmonary Arterial Hypertension (PAH)

A progressive condition characterized by high blood pressure in the arteries supplying the lungs, leading to right-ventricular strain and reduced exercise tolerance.

Buying Eriacta from Our Online pharmacy

Eriacta can be obtained safely through our online pharmacy. We source the medication from licensed, GMP-certified manufacturers and verified international suppliers, ensuring that each tablet meets stringent quality standards.

• Cost-Effective Pricing: Because we operate as a pharmacy-broker service, we can offer Eriacta at a price close to the manufacturer’s production cost, reducing the financial burden for patients who lack insurance coverage or face high retail mark-ups.
• Verified Quality: All batches are checked for potency, purity, and compliance with regulatory specifications before shipment, giving you confidence in the product you receive.
• Discreet, Reliable Delivery: Orders are packaged in neutral, tamper-evident envelopes. Regular airmail takes approximately 2-4 weeks, while express shipping delivers within 5-7 days, both with tracking options.
• Global Access: Our platform provides a legal pathway for patients in regions where Eriacta is not readily stocked in local pharmacies. By partnering with overseas licensed pharmacies, we maintain compliance with international drug-distribution laws while protecting your privacy.

Choosing our online pharmacy means accessing a trusted, affordable, and confidential channel for Eriacta, especially when conventional pharmacy routes are limited or cost-prohibitive.

Disclaimer

The information presented about Eriacta is intended for general educational purposes and does not substitute professional medical assessment. Treatment choices, including any off-label application, must be made under the direct guidance of a qualified healthcare provider. Readers are assumed to be responsible adults capable of evaluating health information critically. Our online pharmacy provides a means to obtain Eriacta for individuals who may encounter limited availability through conventional pharmacy channels or who are seeking cost-effective generic alternatives. Always discuss medication initiation, adjustment, or discontinuation with your clinician before proceeding.