Generic Cobra-120 (Sildenafil Citrate)

Introduction

Cobra-120 is a tablet that contains 120 mg of sildenafil citrate, a phosphodiesterase-5 (PDE5) inhibitor. It belongs to the class of oral vasodilators used primarily for the treatment of erectile dysfunction (ED). The drug is available as a single-strength pill and is supplied by licensed manufacturers that meet international quality standards. In addition to its approved use for ED, sildenafil citrate has a secondary, regulator-approved indication for pulmonary arterial hypertension (PAH) under a different brand formulation. Some clinicians also use sildenafil off-label for conditions such as Raynaud’s phenomenon or high-altitude pulmonary edema, but these uses are not authorized by the U.S. Food and Drug Administration (FDA) or the European Medicines Agency (EMA).

What is Cobra-120?

Cobra-120 is a pharmaceutical product whose sole active ingredient is sildenafil citrate. It is formulated as a round, film-coated tablet containing 120 mg of the active compound, together with inert excipients that aid tablet integrity, dissolution, and stability.

Sildenafil citrate was originally developed by Pfizer in the late s for the treatment of angina. During clinical trials, a pronounced effect on penile erection was observed, leading to its rapid commercialization as a treatment for erectile dysfunction. The molecule is now marketed worldwide under several brand names, most notably Viagra® for ED and Revatio® for PAH. Cobra-120 provides the same therapeutic molecule in a generic formulation, offering a cost-effective alternative for patients who meet the appropriate clinical criteria.

How Cobra-120 Works

Sildenafil citrate blocks the enzyme phosphodiesterase-5 (PDE5) that degrades cyclic guanosine monophosphate (cGMP) in smooth muscle cells. In the penis, sexual stimulation triggers the release of nitric oxide, which raises intracellular cGMP levels. Elevated cGMP relaxes the corpus cavernosum smooth muscle, allowing increased blood flow and erection. By inhibiting PDE5, Cobra-120 prolongs cGMP activity, enhancing the natural erectile response.

For pulmonary arterial hypertension, PDE5 inhibition produces vasodilation in the pulmonary vasculature, lowering pulmonary arterial pressure and improving exercise capacity. Typical onset of action for erectile dysfunction is within 30-60 minutes after ingestion, with a therapeutic window of approximately 4-6 hours. The drug is metabolized primarily by hepatic CYP3A4 and CYP2C9 enzymes, and its half-life ranges from 3 to 5 hours in healthy adults.

Conditions Treated with Cobra-120

• Erectile Dysfunction (ED): Cobra-120 is approved to improve the ability to attain and maintain an erection sufficient for satisfactory sexual activity. Clinical trials demonstrated statistically significant improvements in International Index of Erectile Function (IIEF) scores compared with placebo.

• Pulmonary Arterial Hypertension (PAH) - indirect: While the 120 mg tablet is marketed for ED, sildenafil’s vasodilatory effect is the basis for the PAH indication (available under a lower-dose formulation). Physicians may consider the pharmacology when managing patients with both conditions, though the dosing strategy differs.

The drug’s efficacy in these indications stems from its selective inhibition of PDE5, which is highly expressed in penile and pulmonary vascular smooth muscle.

Off-Label and Investigational Uses of Cobra-120

• Raynaud’s Phenomenon: Small open-label studies suggest that sildenafil can reduce the frequency and severity of ischemic attacks by promoting vasodilation in peripheral vessels. Regulatory agencies have not approved this use, and robust randomized controlled trials are lacking.

• High-Altitude Pulmonary Edema (HAPE): Preliminary research indicates that sildenafil may improve oxygenation and reduce pulmonary artery pressure in individuals exposed to high altitude. The evidence remains experimental, and the safety profile at altitude has not been fully established.

• Benign Prostatic Hyperplasia (BPH) associated with lower urinary tract symptoms: Some investigators have explored sildenafil’s smooth-muscle relaxant properties for relieving urinary flow obstruction. Results are inconclusive, and the indication is not authorized.

Important: Off-label application should only be undertaken under the direct supervision of a qualified healthcare professional, with careful consideration of risks, benefits, and existing evidence.

Is Cobra-120 the Right Medication for You?

Cobra-120 is appropriate for adult males who have a confirmed diagnosis of erectile dysfunction and who do not have contraindications to PDE5 inhibition. Ideal candidates are men who:

• Experience consistent difficulty achieving or maintaining an erection despite adequate sexual stimulation.
• Have stable cardiovascular status, with no recent history of myocardial infarction, unstable angina, or severe heart failure.

Caution is advised, and the medication may be unsuitable for individuals with:

• Concomitant use of nitrates (e.g., nitroglycerin, isosorbide dinitrate) or nitric-oxide donors, as the combination can cause profound hypotension.
• Severe hepatic or renal impairment (e.g., creatinine clearance <30 mL/min) without dose adjustment.
• Certain rare hereditary retinal disorders (e.g., retinitis pigmentosa) because of potential visual disturbances.

Patients with uncontrolled hypertension, recent stroke, or a history of non-arteritic anterior ischemic optic neuropathy should discuss alternative therapies with their provider.

Risks, Side Effects, and Interactions

Common

• Headache
• Flushing
• Dyspepsia (indigestion)
• Nasal congestion
• Visual disturbances (e.g., bluish tint, increased brightness)

These effects are usually mild to moderate and tend to resolve within a few hours.

Rare

• Priapism (prolonged erection lasting >4 hours)
• Sudden hearing loss
• Severe hypotension (particularly when combined with nitrates or alpha-blockers)

Any occurrence of priapism requires immediate medical attention to prevent permanent tissue damage.

Serious

• Cardiovascular events (e.g., myocardial infarction, stroke) in patients with pre-existing cardiovascular disease, though causal attribution to sildenafil is uncommon.
• Non-arteritic anterior ischemic optic neuropathy (NAION) leading to permanent vision loss.

Patients should seek urgent care if they experience chest pain, severe dizziness, sudden vision loss, or an erection that does not subside.

Drug-Drug Interactions

• Nitrates: Concomitant use can precipitate severe hypotension; contraindicated.
• Alpha-blockers (e.g., doxazosin, tamsulosin): May cause additive blood-pressure lowering; start with the lowest dose and monitor.
• CYP3A4 inhibitors (e.g., ketoconazole, ritonavir): Increase sildenafil plasma concentrations, raising the risk of side effects; dose reduction may be required.
• CYP3A4 inducers (e.g., rifampin, carbamazepine): Decrease efficacy; consider alternative therapy.

Food and Lifestyle

• A high-fat meal can delay onset of action by up to 2 hours.
• Moderate alcohol consumption is generally tolerated, but excessive intake amplifies hypotensive effects and may worsen dizziness.

Use: Dosing, Missed Dose, Overdose

• Standard dosing for erectile dysfunction: The recommended starting dose for most men is 50 mg taken as a single tablet about 30 minutes before sexual activity. The dose may be increased to 100 mg or decreased to 25 mg based on efficacy and tolerability. Cobra-120 is supplied only in a 120 mg strength; patients should follow the prescribing clinician’s guidance, which may involve taking the tablet every 24 hours at most.

• Missed dose: If an erection is not anticipated, the tablet can be omitted. However, because the medication is taken only when sexual activity is planned, there is no “daily” schedule to miss. Do not take an extra dose to compensate for a missed one.

• Overdose: Symptoms may include severe headache, prolonged hypotension, priapism, and visual changes. If overdose is suspected, seek emergency medical care immediately. Supportive measures such as intravenous fluids and blood pressure monitoring are typical.

• Administration notes:

  • Swallow the tablet whole with water; do not split, chew, or crush.
  • Avoid taking the medication with grapefruit juice, which can increase systemic exposure.
  • Refrain from operating heavy machinery or driving until you know how the drug affects you, especially if you experience dizziness or visual disturbances.

FAQ

• What should I do with Cobra-120 when traveling internationally?

  • Store the tablets in their original blister pack, away from extreme heat or moisture. Carry them in your hand luggage to avoid temperature fluctuations in cargo holds, and keep a copy of the prescription or a signed statement from a healthcare provider to satisfy customs regulations if required.

• Does Cobra-120 interact with over-the-counter cold medicines?

  • Most OTC decongestants (e.g., pseudoephedrine) do not have a direct pharmacological interaction with sildenafil, but they can raise blood pressure, potentially counteracting sildenafil’s vasodilatory effect. Monitor your blood pressure and discuss any persistent symptoms with a clinician.

• What color and imprint does the Cobra-120 tablet have?

  • The tablet is typically a white, film-coated round pill imprinted with “C120” on one side and the manufacturer’s logo on the other. Inactive ingredients may include lactose, microcrystalline cellulose, and magnesium stearate.

• Can I use Cobra-120 if I have a pacemaker?

  • Sildenafil does not interfere with the electrical function of pacemakers. Nevertheless, patients with significant cardiac disease should have a thorough cardiac evaluation before initiating therapy to ensure safety.

• Is it safe to take Cobra-120 with antihypertensive medication?

  • In most cases, sildenafil can be combined with standard antihypertensives without major issues. However, concurrent use with alpha-blockers or high-dose nitrates requires careful monitoring for additive blood-pressure lowering.

• How long does Cobra-120 remain detectable in drug-testing panels?

  • Standard urine screens do not typically include sildenafil. Specialized testing can detect the drug for up to 48 hours after a single dose, but routine occupational or athletic drug tests rarely screen for PDE5 inhibitors.

• Why is there a 120 mg strength when most guidelines recommend 50-100 mg?

  • The 120 mg tablet offers flexibility for clinicians who wish to titrate the dose upward in patients who have not responded to lower strengths. It is essential to follow a healthcare professional’s individualized dosing plan to avoid excessive exposure.

• Does food affect the absorption of Cobra-120?

  • A high-fat meal can delay absorption and reduce peak plasma concentration, potentially delaying the onset of action by 1-2 hours. For the most reliable effect, take the tablet on an empty stomach or after a light meal.

• Can women use Cobra-120 for any medical condition?

  • Sildenafil is approved for pulmonary arterial hypertension in both sexes under a lower-dose formulation (Revatio). The 120 mg tablet is not indicated for women, and safety data for this dosage in females are insufficient. Women should only use sildenafil if prescribed specifically for PAH at the appropriate dose.

• What is the difference between Cobra-120 and the brand-name Viagra?

  • Both contain the same active molecule, sildenafil citrate, and are bioequivalent when taken at the same dose. The primary differences lie in manufacturing processes, excipients, and pricing; generic versions like Cobra-120 are typically less expensive while meeting the same regulatory standards for quality, safety, and efficacy.

• Is it possible to develop tolerance to Cobra-120?

  • Current evidence shows that pharmacological tolerance to sildenafil does not develop with regular intermittent use. However, psychosocial factors influencing sexual performance may evolve, and patients should discuss any perceived loss of effectiveness with a clinician.

Glossary

Phosphodiesterase-5 (PDE5) Inhibitor

A class of drugs that block the enzyme PDE5, preventing the breakdown of cGMP and thereby promoting smooth-muscle relaxation and vasodilation.

cGMP (Cyclic Guanosine Monophosphate)

A cellular messenger that mediates relaxation of smooth muscle tissue; its accumulation leads to increased blood flow in targeted areas.

Priapism

An erection lasting longer than four hours, which can cause tissue damage if not treated promptly.

Buying Cobra-120 from Our Online Pharmacy

Cobra-120 can be obtained safely through our online pharmacy. We source the medication from licensed, internationally accredited manufacturers that adhere to Good Manufacturing Practice (GMP) standards, ensuring each tablet meets strict potency and purity criteria.

• Cost-effective pricing: Because we purchase directly from certified bulk suppliers, we can offer Cobra-120 at a price close to the manufacturer’s baseline, substantially lower than many local retail outlets.
• Verified quality: Every batch is tested for content uniformity, dissolution, and microbiological safety before it leaves our fulfillment center.
• Discreet delivery: Orders are packaged in unmarked, tamper-evident envelopes and shipped via reliable carriers. Express options typically arrive within 7 days, while standard airmail takes about 3 weeks, depending on destination.
• Privacy-focused service: As a pharmacy-broker, we work with overseas licensed pharmacies to bring medicines that may be unavailable or cost-prohibitive in certain regions. Your personal information is encrypted and stored securely, and no external parties can access your order details.

Our platform is designed for adults who need reliable, affordable access to generic sildenafil citrate without compromising safety or confidentiality.

Disclaimer

The information presented about Cobra-120 is intended for general educational purposes and does not substitute professional medical advice. Treatment choices, including any off-label applications, must be made under the direct supervision of a qualified healthcare provider. Readers are assumed to be responsible adults capable of making informed health decisions. Our online pharmacy supplies Cobra-120 to individuals who may encounter limited access through conventional pharmacies or insurance-based dispensing, or who are seeking a cost-effective generic alternative. Always discuss any medication changes, initiation, or discontinuation with your clinician before proceeding.