Cialis Pack-60

Introduction

Cialis Pack-60 is a tablet formulation supplied in packs of 60 units. It contains the phosphodiesterase-5 (PDE-5) inhibitor tadalafil as its active pharmaceutical ingredient. Tadalafil belongs to the class of medicines used to improve blood flow in the penis and to relax smooth muscle in the pulmonary vasculature. The product is manufactured by several licensed pharmaceutical companies worldwide and is available in a standard 20 mg dose per tablet. Approved therapeutic indications include erectile dysfunction (ED) and pulmonary arterial hypertension (PAH). In clinical practice the medication is also explored for a limited set of off-label applications, which are discussed with appropriate caution.

What is Cialis Pack-60?

• Definition - Cialis Pack-60 is a oral tablet containing 20 mg of tadalafil. Each pack holds 60 tablets, intended for chronic or as-needed therapy.
• Pharmacological class - PDE-5 inhibitor.
• Development history - Tadalafil was discovered by ICOS (later acquired by Eli Lilly) and received FDA approval in 2003 for erectile dysfunction, followed by approval for PAH in 2009. Generic versions, such as Cialis Pack-60, have been produced after patent expiry, offering a cost-effective alternative.
• Manufacturer - Various globally licensed manufacturers produce the generic; the specific label on a pack will indicate the responsible company.

Cialis Pack-60 is the generic version of the well-known medication marketed under brand names such as Cialis and Adcirca. Our online pharmacy provides this generic alternative as a cost-effective treatment option.

How Cialis Pack-60 Works

Tadalafil blocks the enzyme phosphodiesterase-5, which normally degrades cyclic guanosine monophosphate (cGMP). Inhibition raises intracellular cGMP levels, leading to:

1. Relaxation of smooth muscle in the corpus cavernosum, allowing arterial inflow and erection when sexual stimulation occurs.
2. Pulmonary vasodilation by relaxing smooth muscle in the pulmonary arteries, reducing pulmonary vascular resistance in PAH.

The onset of action for erectile dysfunction typically occurs within 30 minutes, with a therapeutic window that can extend up to 36 hours, making it distinct among PDE-5 inhibitors. The plasma half-life is approximately 17.5 hours, supporting once-daily dosing for PAH and on-demand dosing for ED.

Conditions Treated with Cialis Pack-60

Both indications are supported by regulatory approvals from the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA).

Off-Label and Investigational Uses of Cialis Pack-60

• Benign Prostatic Hyperplasia (BPH) symptom relief - Clinical studies have shown that daily tadalafil (5 mg) can modestly improve lower urinary tract symptoms; however, the 20 mg dose for BPH is not approved.
• Raynaud’s phenomenon - Small pilot trials suggest possible vasodilatory benefit, but evidence remains preliminary.
• Female sexual arousal disorder - Limited data indicate potential improvement in genital blood flow; regulatory bodies have not approved this use.

These applications are not authorized by the FDA or EMA. Patients should consider off-label therapy only under direct supervision of a qualified healthcare provider.

Is Cialis Pack-60 the Right Medication for You?

• Suitable candidates - Adult men with a documented diagnosis of erectile dysfunction and men with WHO Group 1 pulmonary arterial hypertension. Patients who require a long duration of action (up to 36 hours) often prefer tadalafil over shorter-acting PDE-5 inhibitors.
• Clinical scenarios favoring use -
  • Need for spontaneous sexual activity without timing a dose immediately before intercourse.
  • Chronic management of PAH where once-daily dosing improves adherence.
• Contraindications - Known hypersensitivity to tadalafil or any component of the tablet, concurrent use of nitrates (e.g., nitroglycerin), or severe uncontrolled hypertension. Patients with recent myocardial infarction or stroke should be evaluated carefully before initiating therapy.

Risks, Side Effects, and Interactions

Common

• Headache
• Dyspepsia (indigestion)
• Back pain
• Myalgia (muscle aches)
• Nasal congestion

These events are generally mild to moderate and often resolve without intervention.

Rare

• Priapism (prolonged erection lasting > 4 hours) - requires immediate medical attention.
• Vision changes such as blurred vision or a bluish tint (cyanopsia).
• Hearing loss or sudden decrease in hearing.

Serious

• Severe hypotension, especially when combined with nitrates.
• Cardiovascular events (myocardial infarction, stroke) in high-risk individuals.
• Allergic reactions (rash, pruritus, anaphylaxis).

Drug-Drug Interactions

• Nitrates (e.g., isosorbide dinitrate) - synergistic vasodilation → dangerous hypotension.
• Alpha-blockers (e.g., doxazosin) - may cause additive blood pressure lowering; start at low dose.
• CYP3A4 inhibitors (ketoconazole, erythromycin, ritonavir) - increase tadalafil plasma concentrations → higher risk of side effects.
• CYP3A4 inducers (rifampin, carbamazepine) - may reduce efficacy.

Drug-Food Interactions

• High-fat meals can delay onset of action but do not affect overall efficacy.
• Moderate alcohol consumption generally safe; excessive alcohol may increase risk of dizziness and hypotension.

Use: Dosing, Missed Dose, Overdose

• Standard dosing for ED - 20 mg taken as a single tablet prior to anticipated sexual activity. May be reduced to 10 mg or increased to 20 mg based on efficacy and tolerability. No more than one dose per 24 hours.
• Daily dosing for PAH - 40 mg taken once daily, preferably at the same time each day.
• Missed dose - If a dose is forgotten, take it as soon as remembered, provided at least 24 hours have not elapsed since the previous dose. Otherwise, skip the missed dose and continue with the next scheduled dose.
• Overdose - Signs may include severe headache, hypotension, prolonged erection, or syncope. Seek emergency medical care promptly. Supportive treatment (e.g., intravenous fluids, vasopressors) is administered as needed.

Practical precautions

• Tablets can be taken with or without food.
• Limit alcohol intake to moderate amounts to avoid additive hypotensive effects.
• Avoid operating heavy machinery or driving if dizziness occurs.

FAQ

• What is the shelf life of Cialis Pack-60 tablets?

  • The product remains stable for two years from the date of manufacture when stored below 30 °C (86 °F) in a dry environment. Check the expiration date on the packaging.

• Can Cialis Pack-60 be taken by women for any indication?

  • Tadalafil is not approved for use in women. Off-label use for female sexual arousal has been investigated but lacks sufficient evidence for safety and efficacy.

• How should the tablets be stored while traveling abroad?

  • Keep tablets in their original blister pack, protected from excessive heat, moisture, and direct sunlight. A small insulated pouch can help maintain stable temperature during long flights.

• Does tadalafil interact with herbal supplements such as St. John’s wort?

  • St. John’s wort induces CYP3A4, potentially lowering tadalafil concentrations and reducing therapeutic effect. Discuss any supplement use with a healthcare professional.

• Is there a difference between the 10 mg and 20 mg tablet strengths?

  • Both strengths contain tadalafil; the 20 mg tablet delivers a higher systemic exposure, which may improve efficacy for some patients but also elevates the risk of side effects. Dose selection is individualized.

• Can I split a 20 mg tablet to achieve a lower dose?

  • Tadalafil tablets are not scored. Splitting may result in uneven dosing and is not recommended. Use the approved lower-strength tablet if a smaller dose is required.

• Will taking Cialis Pack-60 affect routine blood tests?

  • Tadalafil does not interfere with standard laboratory assays. However, it may be detectable in specialized drug-screening tests, which are uncommon in routine health panels.

• Are there special precautions for patients with chronic kidney disease?

  • Mild to moderate renal impairment does not require dose adjustment, but severe renal dysfunction (creatinine clearance < 30 mL/min) may necessitate a reduced dose and close monitoring.

• How long does it take for the medication to be eliminated from the body?

  • The elimination half-life is roughly 17.5 hours; therefore, most of the drug is cleared after about 3-4 days, assuming normal hepatic and renal function.

• Is it safe to combine Cialis Pack-60 with antihypertensive medication?

  • Concurrent use is common; however, additive blood-pressure-lowering effects can occur, especially with alpha-blockers or nitroglycerin. Blood pressure should be monitored after initiating therapy.

Glossary

Phosphodiesterase-5 (PDE-5) inhibitor

A drug class that blocks the enzyme responsible for breaking down cGMP, thereby promoting smooth-muscle relaxation and vasodilation.

cGMP (cyclic guanosine monophosphate)

A second messenger molecule that mediates vascular smooth-muscle relaxation; increased levels lead to improved blood flow.

Pulmonary arterial hypertension (PAH)

A progressive condition characterized by high blood pressure in the arteries of the lungs, leading to right-heart strain.

Priapism

An erection lasting longer than four hours, unrelated to sexual stimulation, which can cause permanent tissue damage if untreated.

Buying Cialis Pack-60 from Our Online Pharmacy

Patients who encounter cost barriers, limited local availability, or privacy concerns can obtain Cialis Pack-60 through our online pharmacy.

• Affordability - Prices are set close to manufacturer cost, offering a significant saving compared with branded versions.
• Verified quality - All tablets are sourced from licensed, GMP-certified suppliers that meet international regulatory standards.
• Reliable delivery - Discreet packaging is shipped worldwide; express service typically arrives within 7 days, while standard airmail takes 2-3 weeks.
• Privacy-focused service - As a pharmacy-broker, we partner with overseas licensed pharmacies, enabling a secure, confidential transaction that respects patient anonymity.

By choosing our online pharmacy, patients gain a trusted channel to access a clinically effective medication without compromising on safety or affordability.

Disclaimer

The information provided about Cialis Pack-60 is intended for general educational purposes only and does not substitute professional medical advice. All therapeutic decisions, including those concerning off-label applications, should be made under the direct supervision of a qualified healthcare provider. Readers are presumed to be competent adults capable of making informed health choices. Our online pharmacy offers access to Cialis Pack-60 for individuals who may face limited availability through conventional pharmacies or who seek a cost-effective generic alternative. Prior to initiating, changing, or stopping any medication, consult your physician.