Caverta (Sildenafil Citrate)

Introduction

Caverta is a tablet that contains the active ingredient Sildenafil Citrate. It is manufactured as a generic product and is supplied in strengths of 50 mg and 100 mg. Sildenafil Citrate belongs to the phosphodiesterase-5 (PDE5) inhibitor class and is primarily prescribed for the treatment of erectile dysfunction (ED). In some jurisdictions the same compound is also approved for pulmonary arterial hypertension under a different brand name. Off-label uses have been explored in clinical research, but they remain unapproved by the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA).

What is Caverta?

Caverta is the generic version of well-known medications, containing the active compound Sildenafil Citrate. Our online pharmacy provides this generic alternative as a cost-effective treatment option. Sildenafil was originally developed by Pfizer and marketed under the brand name Viagra for erectile dysfunction and Revatio for pulmonary arterial hypertension. Caverta contains the same molecule, formulated as an oral tablet, and is intended to give patients comparable therapeutic benefit at a lower price.

The product is supplied in two dosage strengths-50 mg and 100 mg-and is classified as a prescription-only medication in most countries because of its pharmacologic activity and potential interactions.

How Caverta Works

Sildenafil Citrate inhibits the enzyme phosphodiesterase-5 (PDE5) found in the smooth muscle of the corpus cavernosum and the pulmonary vasculature. Under sexual stimulation, nitric oxide (NO) is released from nerves and endothelial cells, activating guanylate cyclase and increasing cyclic guanosine monophosphate (cGMP). cGMP relaxes smooth muscle, allowing blood to fill the erectile tissue. PDE5 rapidly degrades cGMP; by blocking this enzyme, Sildenafil sustains higher cGMP levels, prolonging smooth-muscle relaxation and facilitating erection.

In the pulmonary circulation, the same mechanism reduces vascular resistance, improving exercise capacity in patients with pulmonary arterial hypertension. Onset of action typically occurs within 30-60 minutes after oral ingestion, with a therapeutic window of about 4-6 hours. The drug is metabolized primarily by hepatic CYP3A4 and CYP2C9 enzymes, and its elimination half-life ranges from 3 to 5 hours.

Conditions Treated with Caverta

• Erectile Dysfunction (ED) - The only FDA-approved indication for Sildenafil in its 50 mg and 100 mg tablet form. By enhancing the NO-cGMP pathway, Caverta improves the ability to achieve and maintain an erection sufficient for sexual activity.

• Pulmonary Arterial Hypertension (PAH) - While Caverta is not marketed under the Revatio label, the same active ingredient is approved for PAH. Clinically, the drug lowers pulmonary arterial pressure and improves exercise tolerance.

These indications are supported by large-scale randomized controlled trials (e.g., the Sildenafil Study Group, N Engl J Med 1998) and have been incorporated into international treatment guidelines.

Off-Label and Investigational Uses of Caverta

• Benign Prostatic Hyperplasia (BPH) - Small studies have reported improvement in lower-urinary-tract symptoms when Sildenafil is added to standard therapy, likely due to smooth-muscle relaxation in the prostate and bladder neck. This use is not FDA-approved and requires physician supervision.

• Raynaud’s Phenomenon - Case series suggest that PDE5 inhibition may reduce the frequency and severity of digital vasospasm. Evidence remains limited to observational data.

• High-Altitude Pulmonary Edema (HAPE) - Experimental work indicates that Sildenafil can lower pulmonary artery pressure in high-altitude settings, but clinical trials are ongoing.

• Female Sexual Arousal Disorder - Preliminary trials explored Sildenafil as a potential treatment for women with low sexual desire, yet results have been inconsistent, and safety data are insufficient for regulatory approval.

All off-label applications should be considered only after a thorough risk-benefit assessment by a qualified healthcare professional.

Is Caverta the Right Medication for You?

Caverta is most appropriate for adult men diagnosed with erectile dysfunction who have adequate cardiovascular health to tolerate sexual activity. It is also suitable for patients with confirmed pulmonary arterial hypertension when prescribed by a specialist.

Situations favoring Caverta:

• Stable cardiovascular status (no recent myocardial infarction, uncontrolled hypertension, or severe arrhythmia)
• Ability to abstain from nitrate medications (e.g., nitroglycerin)
• No concurrent use of strong CYP3A4 inhibitors unless dose adjustment is made

Contraindications:

• Use of any organic nitrates or nitric oxide donors
• Known hypersensitivity to Sildenafil or any tablet excipients
• Severe hepatic impairment (Child-Pugh C) or end-stage renal disease not on dialysis

Patients with uncontrolled hypertension, recent stroke, or those taking certain alpha-blockers should discuss alternative therapies with their clinician.

Risks, Side Effects, and Interactions

Common

• Headache
• Facial flushing
• Dyspepsia (indigestion)
• Nasal congestion

These events are usually mild, transient, and resolve without intervention.

Rare

• Visual disturbances (e.g., blue-tinted vision, increased light sensitivity)
• Hearing loss or tinnitus
• Priapism (prolonged erection lasting > 4 hours)

If any rare symptom persists, medical evaluation is advisable.

Serious

• Cardiovascular events (myocardial infarction, severe hypotension) in patients with pre-existing heart disease
• Severe allergic reactions (anaphylaxis, angioedema)
• Sudden loss of vision (non-arteritic anterior ischemic optic neuropathy)

Immediate emergency care is required for serious adverse events.

Drug-Drug Interactions

• Nitrates (e.g., nitroglycerin, isosorbide dinitrate) - can cause profound hypotension.
• Potent CYP3A4 inhibitors (ketoconazole, clarithromycin, ritonavir) - increase Sildenafil plasma levels; dose reduction may be needed.
• Alpha-blockers (tamsulosin, doxazosin) - may produce additive blood-pressure lowering effects.

Drug-Food Interactions

• High-fat meals - delay absorption and reduce peak concentration; take the tablet on an empty stomach for faster onset.
• Alcohol - can potentiate hypotensive effects and increase the risk of dizziness.

Use: Dosing, Missed Dose, Overdose

• Initial dose for most men with ED: 50 mg taken as needed, about 30-60 minutes before sexual activity.
• Dose titration: Based on efficacy and tolerance, the dose may be increased to 100 mg or decreased to 25 mg (if available) no more than once per day.
• Maximum recommended dose: 100 mg per day.

Missed dose - Since Caverta is taken only when sexual activity is anticipated, there is no scheduled daily dosing. If a dose is taken and intercourse does not occur within 4 hours, the remaining medication should be discarded; do not double-dose.

Overdose - Symptoms may include severe hypotension, prolonged erection, or syncope. Seek urgent medical attention. Treatment is supportive; there is no specific antidote.

Administration tips - Swallow the tablet whole with water. Avoid taking with grapefruit juice, which can inhibit CYP3A4 and raise drug levels. Do not operate heavy machinery until you know how the medication affects you, especially if you experience dizziness or visual changes.

FAQ

• What should I do if I travel abroad with Caverta?

  • Carry the medication in its original packaging with a copy of the prescription label. Keep it in your carry-on luggage to avoid temperature extremes in checked bags.

• Can I store Caverta in a humid climate?

  • Store tablets at 20-25 °C (68-77 °F) in a dry place. Excessive humidity may degrade the tablet coating; a sealed container helps maintain stability.

• Does the tablet contain any allergens?

  • Inactive ingredients typically include lactose, magnesium stearate, and microcrystalline cellulose. Patients with severe lactose intolerance should verify the formulation with the supplier.

• Are there regional differences in tablet appearance?

  • Generic Sildenafil tablets may vary in size, shape, and imprint depending on the manufacturer. Caverta tablets are scored for easy splitting and are marked with “CAV 50” or “CAV 100” to indicate strength.

• How does Caverta compare to the original brand in terms of efficacy?

  • Bioequivalence studies required by regulatory agencies show that generic Sildenafil, including Caverta, delivers plasma concentrations within 80-125 % of the reference product, indicating comparable efficacy.

• Is it safe to use Caverta together with herbal supplements like ginseng?

  • Ginseng may have mild vasodilatory effects, but there is limited evidence of a direct interaction. Nonetheless, discuss any supplement use with your clinician to rule out additive blood-pressure effects.

• Can I take Caverta if I have diabetes?

  • Diabetes itself is not a contraindication. However, diabetic patients often have concurrent cardiovascular disease; a thorough assessment of heart health is advisable before initiating therapy.

• What is the impact of age on dosing?

  • Older adults (≥ 65 years) may have reduced hepatic clearance and are more prone to hypotension. Starting at the lower 50 mg dose and monitoring tolerability is recommended.

• Does Caverta affect laboratory drug testing?

  • Standard drug screens do not detect Sildenafil. However, forensic toxicology panels designed to identify PDE5 inhibitors can detect the compound if specifically requested.

• Why does the effect sometimes feel weaker after repeated use?

  • Psychological factors, disease progression, or reduced nitric-oxide availability can diminish the perceived benefit. Adjusting dose or evaluating underlying health conditions may help restore effectiveness.

Glossary

Phosphodiesterase-5 (PDE5) inhibitor

A class of drugs that block the PDE5 enzyme, preventing the breakdown of cGMP and thereby promoting smooth-muscle relaxation in the penis and pulmonary vessels.

cGMP (cyclic guanosine monophosphate)

A secondary messenger molecule that mediates vasodilation; higher levels lead to smooth-muscle relaxation and increased blood flow.

Bioequivalence

A regulatory standard indicating that two drug products release the same amount of active ingredient into the bloodstream at a comparable rate and extent.

Priapism

A prolonged, often painful erection lasting more than four hours, which can cause permanent tissue damage if not treated promptly.

Buying Caverta from Our Online Pharmacy

Patients who need reliable, affordable access to generic Sildenafil often encounter price barriers or limited stock at local pharmacies. Our online pharmacy offers Caverta at a cost close to the manufacturer’s price, eliminating the typical retail markup. Each product batch is sourced from licensed, audited suppliers that comply with Good Manufacturing Practice (GMP) standards, ensuring that you receive a medication that meets the same quality criteria as brand-name equivalents.

Discreet packaging protects your privacy, and the delivery system provides tracking so you know exactly when your order will arrive-typically within 7 days for express shipments or about 3 weeks for standard airmail, depending on your location. Because we operate as a pharmacy-broker service, we can source Caverta from multiple overseas licensed pharmacies, expanding availability for patients whose domestic options are scarce.

Choosing our service means you benefit from a transparent pricing model, verified product authenticity, and a commitment to confidentiality throughout the fulfillment process.

Disclaimer

The information presented about Caverta is intended for general educational purposes and does not substitute for professional medical advice. Treatment decisions-including any off-label use-should be made under the guidance of a qualified healthcare provider. Readers are presumed to be competent adults capable of making informed health choices. Our online pharmacy supplies Caverta to individuals who may encounter limited access through conventional pharmacies or who seek cost-effective generic alternatives. Always discuss any changes to your medication regimen with a clinician before initiating, adjusting, or discontinuing therapy.