Generic Androxal (Enclomiphene )

Introduction

Androxal is a oral tablet that contains the selective estrogen receptor modulator (SERM) enclomiphene as its sole active ingredient. Each tablet is supplied in a 50 mg dose. The drug belongs to the class of non-steroidal estrogen-receptor antagonists that are used to modify the hypothalamic-pituitary-gonadal (HPG) axis. In several jurisdictions enclomiphene has received regulatory approval for the treatment of secondary (hypogonadotropic) male hypogonadism, a condition characterized by low testosterone levels due to impaired signaling from the brain to the testes. The medication is also investigated for other endocrine applications, but those uses are not yet approved by major agencies such as the U.S. Food and Drug Administration (FDA) or the European Medicines Agency (EMA).

What is Androxal?

Androxal is a single-entity pharmaceutical product whose only pharmacologically active component is enclomiphene. Enclomiphene is the trans-isomer of clomiphene, a well-known SERM that has been used for decades to induce ovulation in women. Androxal is manufactured by a licensed producer that follows current Good Manufacturing Practice (cGMP) standards. The tablet is film-coated, white to off-white, and each contains 50 mg of enclomiphene citrate.

How Androxal Works

Enclomiphene binds to estrogen receptors in the hypothalamus and pituitary gland, blocking the negative feedback normally exerted by circulating estradiol. This antagonism signals the hypothalamus to increase gonadotropin-releasing hormone (GnRH) secretion. Elevated GnRH stimulates the anterior pituitary to release more luteinizing hormone (LH) and follicle-stimulating hormone (FSH). In men, the rise in LH drives Leydig cells in the testes to produce testosterone, while the increase in FSH supports spermatogenesis. The net effect is a physiological elevation of endogenous testosterone without the need for exogenous androgen replacement. The onset of hormonal changes is typically observed within 2-3 weeks of daily dosing, with peak testosterone levels reached after 4-6 weeks. Enclomiphene has a half-life of approximately 10 hours; steady-state concentrations are achieved after about 5 days of consistent use.

Conditions Treated with Androxal

• Secondary (hypogonadotropic) male hypogonadism - In countries where regulatory approval has been granted, Androxal is indicated to raise serum testosterone in men whose low levels are caused by insufficient LH/FSH secretion rather than primary testicular failure. The drug restores normal testosterone production while preserving fertility, an advantage over traditional testosterone replacement therapy (TRT).

Off-Label and Investigational Uses of Androxal

• Female infertility (anovulation) - Early clinical studies with the racemic mixture clomiphene demonstrated ovulation induction. Isolated enclomiphene has been examined in small trials as a potentially safer alternative, but it is not approved for this indication in any major market.
• Age-related testosterone decline (late-onset hypogonadism) - Some investigators have assessed enclomiphene in men over 50 with modestly reduced testosterone. Results suggest modest testosterone increases without suppressing spermatogenesis, yet regulatory bodies have not approved this use.
• Adjunct in assisted reproductive technology (ART) - Limited data indicate that enclomiphene pretreatment may improve sperm parameters before in-vitro fertilization (IVF). This application remains investigational.

All off-label applications should be undertaken only under direct supervision of a qualified healthcare provider. The safety and efficacy for these uses have not been formally evaluated by the FDA, EMA, or comparable agencies.

Is Androxal the Right Medication for You?

Androxal is appropriate for adult men who have documented secondary hypogonadism, confirmed by low serum testosterone together with low or inappropriately normal LH/FSH levels. It is especially useful when preservation of fertility is a priority, because the drug stimulates endogenous testosterone production rather than delivering exogenous hormone.

Contraindications include:

• Known hypersensitivity to enclomiphene or any tablet excipients.
• Active or recent (within 3 months) thromboembolic disease.
• Uncontrolled hypertension or severe cardiovascular disease.
• Current use of estrogenic medications (e.g., hormone replacement therapy) that could counteract the drug’s mechanism.

Patients with liver dysfunction, a history of hormone-sensitive cancers (breast, prostate), or who are pregnant/breast-feeding should avoid the medication.

Risks, Side Effects, and Interactions

Common

• Hot flashes - transient vasomotor symptoms reported in up to 15 % of users.
• Headache - typically mild to moderate in intensity.
• Nausea or mild gastrointestinal discomfort - usually resolves after the first few days.

Rare

• Visual disturbances - such as blurred vision or photophobia, occurring in <1 % of patients.
• Mood changes - irritability or mild depression reported sporadically.

Serious

• Thromboembolic events - deep-vein thrombosis or pulmonary embolism; incidence is very low but warrants immediate medical attention.
• Severe hepatic impairment - marked elevation of liver enzymes; monitor liver function tests periodically.
• Allergic reaction - angioedema or anaphylaxis; discontinue immediately and seek emergency care.

Drug-Drug Interactions

• CYP2D6 inhibitors (e.g., fluoxetine, paroxetine) - may increase enclomiphene plasma concentrations, potentially heightening adverse effects.
• Anticoagulants (warfarin, direct oral anticoagulants) - due to the rare risk of thrombosis, concurrent use should be monitored closely.
• Hormonal contraceptives or estrogen therapy - antagonistic action may reduce the efficacy of estrogen-containing products.

Drug-Food Interactions

• Grapefruit juice - can inhibit CYP3A4 metabolism and modestly raise drug levels; patients are advised to avoid large quantities.

Use: Dosing, Missed Dose, Overdose

• Standard dosing - The typical adult regimen is 50 mg taken orally once daily, preferably in the morning with a glass of water. Dose adjustments are not routinely required, but clinicians may titrate based on serum testosterone response and tolerability.
• Missed dose - If a dose is forgotten, take it as soon as remembered on the same day. If it is already close to the time of the next scheduled dose, skip the missed tablet and resume the regular dosing schedule. Do not double-dose.
• Overdose - Accidental ingestion of more than the prescribed amount should be treated as a medical emergency. Symptoms may include severe nausea, vomiting, dizziness, or visual changes. Contact emergency services or a poison-control center immediately.
• Administration considerations - The tablet may be taken with or without food; however, a high-fat meal can delay absorption slightly. Alcohol should be limited, as chronic intake may exacerbate hepatic stress. Patients should avoid operating heavy machinery until they know how the drug affects them, especially during the first weeks of therapy.

FAQ

• What storage conditions are recommended for Androxal tablets?   Androxal should be kept in its original container, tightly closed, at controlled room temperature (20-25 °C). Protect the tablets from excess moisture, direct sunlight, and heat above 30 °C.

• Can I travel internationally with Androxal?   Yes, provided you carry the medication in its original packaging with a copy of the prescription or a physician’s note. Some countries require a declaration for hormonal agents; verify local import rules before departure.

• What do the imprints on the tablet look like?   Each 50 mg enclomiphene tablet is typically imprinted with “ENCL-50” on one side and a batch code on the opposite side. The tablet is round, film-coated, and white to off-white.

• Are there any gluten-free or vegan formulations of Androxal?   The standard tablet contains lactose and may use gelatin as a binder. Patients with strict dietary restrictions should consult the pharmacy for a verified formulation list before ordering.

• Will Androxal appear on standard drug tests?   Enclomiphene is not part of routine occupational drug-screening panels. However, specialized anti-doping laboratories can detect SERMs; athletes subject to WADA testing should disclose use.

• How long does it take for testosterone levels to stabilize after starting Androxal?   Serum testosterone typically rises within 2-3 weeks, reaching a plateau around 4-6 weeks. Periodic monitoring every 4-6 weeks during the titration phase is recommended.

• Is Androxal safe for men with a history of prostate cancer?   Enclomiphene can increase circulating testosterone, which may theoretically stimulate prostate cancer cells. Current guidelines advise against use in patients with active or a history of prostate malignancy unless explicitly authorized by a specialist.

• Can Androxal be taken with over-the-counter supplements such as zinc or vitamin D?   Yes, micronutrient supplements generally do not interact with enclomiphene. Nonetheless, high-dose zinc can affect hormonal balance; patients should keep supplement doses within recommended daily allowances.

• What is the difference between enclomiphene and clomiphene?   Clomiphene is a racemic mixture of two isomers: enclomiphene (trans) and zuclomiphene (cis). Enclomiphene retains the estrogen-receptor antagonism responsible for gonadotropin elevation, whereas zuclomiphene has a longer half-life and can exert partial agonist activity. Androxal contains only the trans-isomer, providing a more predictable pharmacokinetic profile.

• Does Androxal affect fertility testing results?   Because enclomiphene stimulates endogenous testosterone and spermatogenesis, semen parameters may improve. However, the drug can also cause transient fluctuations in hormone assays; laboratories should be informed of ongoing therapy when interpreting results.

Glossary

Selective Estrogen Receptor Modulator (SERM)

A class of compounds that bind to estrogen receptors and act as antagonists in some tissues (e.g., hypothalamus) while acting as agonists in others (e.g., bone).

Hypogonadotropic hypogonadism

A form of low testosterone caused by insufficient signaling from the brain (low LH/FSH), rather than direct testicular failure.

Steady-state concentration

The point during repeated dosing when the rate of drug administration equals the rate of elimination, resulting in a relatively constant plasma level.

Pharmacokinetic half-life

The time required for the plasma concentration of a drug to decrease by 50 % after reaching steady state.

Buying Androxal from Our Online pharmacy

Patients who need enclomiphene but encounter limited availability or high out-of-pocket costs can obtain Androxal through our online pharmacy. We source the medication exclusively from licensed, audited manufacturers that comply with cGMP standards, ensuring that each tablet meets stringent quality criteria. Because we act as a pharmacy-broker service, we can negotiate directly with overseas suppliers, which translates into pricing that is often close to the manufacturer’s list price.

Delivery is discreet and reliable. Standard airmail shipments typically arrive within three weeks, while an express option is available for delivery in about seven business days. All packages are sealed in plain, unmarked envelopes to protect patient privacy.

Our platform is designed for patients who may lack insurance coverage for this specialty medication or who reside in regions where Androxal is not stocked in local pharmacies. By choosing our online pharmacy, you gain a convenient, cost-effective pathway to a medically verified product while maintaining the confidentiality you expect.

Disclaimer

The information presented about Androxal is intended for general educational purposes only and does not replace professional medical advice. Treatment decisions, including any off-label applications, must be made under the direct supervision of a qualified healthcare professional. Readers are presumed to be competent adults capable of evaluating health-related information responsibly. Our online pharmacy offers access to Androxal for individuals who may encounter limited availability through conventional pharmacies or insurance formularies, or who are seeking affordable generic alternatives. Always consult a qualified clinician before initiating, modifying, or discontinuing any medication.