Generic Viagra With Dapoxetine (Sildenafil with Dapoxetine)

Introduction

Viagra with Dapoxetine is a fixed-dose combination tablet that contains the phosphodiesterase-5 (PDE5) inhibitor sildenafil and the short-acting selective serotonin-reuptake inhibitor (SSRI) dapoxetine. The product is supplied as a 100 mg sildenafil / 60 mg dapoxetine tablet. It belongs to the therapeutic groups of erectile-dysfunction agents and premature-ejaculation treatments. The primary approved indication is the coincident management of erectile dysfunction (ED) and premature ejaculation (PE) in adult men. The medication is manufactured by several licensed pharmaceutical companies and is distributed in many jurisdictions through regulated channels.

What is Viagra with Dapoxetine?

Viagra with Dapoxetine is the generic version of well-known medications, containing the active compound Sildenafil with Dapoxetine. Our online pharmacy provides this generic alternative as a cost-effective treatment option.

• Classification: Fixed-dose combination of a PDE5 inhibitor (sildenafil) and a short-acting SSRI (dapoxetine).
• Development history: Sildenafil was first approved for ED in 1998 (brand name Viagra). Dapoxetine received approval for PE in 2009 (brand name Priligy). Combining the two agents in a single tablet was pursued to simplify therapy for men who experience both conditions simultaneously.
• Manufacturer: Various licensed manufacturers produce the combination; each must meet Good Manufacturing Practice (GMP) standards required by the FDA, EMA, or comparable regulatory bodies.

How Viagra with Dapoxetine Works

• Sildenafil: Inhibits the enzyme phosphodiesterase-5 in the corpus cavernosum. This inhibition prevents the breakdown of cyclic guanosine monophosphate (cGMP), a messenger that relaxes smooth muscle and allows increased blood flow into the penis after sexual stimulation. The result is an erection sufficient for intercourse.
• Dapoxetine: Blocks the re-uptake of serotonin at the synaptic cleft, reducing the ejaculatory threshold within the central nervous system. Because dapoxetine has a rapid onset (about 1-2 hours) and a short half-life (~1.5 hours), it can be taken on demand without lingering serotonergic effects.
• Combined effect: The tablet addresses two distinct physiological pathways - penile vascular engorgement and ejaculatory control - enabling men to achieve and maintain an erection while extending intravaginal ejaculation latency time (IELT). Onset of action for the combination is typically 30-60 minutes after oral intake, with an effective window of up to 4-6 hours, depending on individual metabolism and food intake.

Conditions Treated with Viagra with Dapoxetine

• Erectile Dysfunction (ED): A persistent inability to achieve or maintain an erection sufficient for satisfactory sexual performance. Sildenafil restores erectile physiology by enhancing the nitric-oxide/cGMP pathway.
• Premature Ejaculation (PE): Ejaculation that occurs within about one minute of vaginal penetration or before the man wishes it, causing distress. Dapoxetine prolongs IELT by modulating serotonergic pathways.

The combination is approved when both conditions coexist, allowing a single daily dose rather than two separate medications.

Off-Label and Investigational Uses of Viagra with Dapoxetine

• Female Sexual Arousal Disorder (FSAD): Small pilot studies have explored sildenafil’s vasodilatory effects in women, while dapoxetine’s impact on serotonergic modulation has been examined for orgasmic latency. Evidence remains limited, and regulatory approval is absent.
• Pulmonary Hypertension (PH): Sildenafil is an established therapy for PH, but dapoxetine adds no known benefit. Some clinicians have reported off-label use of the combination in patients with both PH and concurrent PE, although safety data are sparse.
• Psychogenic Erectile Dysfunction: In cases where anxiety or depressive symptoms exacerbate ED, the serotonergic action of dapoxetine may provide ancillary mood stabilization, but this is not an approved indication.

All off-label applications must be undertaken only under the direct supervision of a qualified healthcare provider.

Is Viagra with Dapoxetine the Right Medication for You?

• Suitable patients: Adult men (≥18 years) diagnosed with both ED and PE, who have an adequate response to sexual stimulation and no contraindications to either sildenafil or dapoxetine.
• Clinical scenarios favoring use: Patients who desire a single-pill regimen, those who have demonstrated adherence challenges with multiple medications, and individuals who report that treating one condition alone does not fully resolve sexual dissatisfaction.

Contraindications include:

• Use of nitrates (e.g., nitroglycerin) or nitric-oxide donors within 24 hours.
• Severe uncontrolled hypertension or hypotension.
• Known hypersensitivity to sildenafil, dapoxetine, or any excipients.
• Recent (≤ 3 months) cerebrovascular accident or myocardial infarction.
• Concomitant use of potent CYP3A4 inhibitors (e.g., ketoconazole, ritonavir) that could raise sildenafil levels dramatically.

Patients with severe hepatic or renal impairment should be evaluated carefully before initiating therapy.

Risks, Side Effects, and Interactions

Common

• Headache
• Flushing
• Nasal congestion
• Dyspepsia (indigestion)
• Nasal stuffiness
• Diarrhea (more often related to dapoxetine)
• Dizziness

Rare

• Visual disturbances (e.g., bluish tint, increased sensitivity to light)
• Auditory changes (tinnitus, hearing loss)
• Priapism (prolonged erection lasting > 4 hours)

Serious

• Cardiovascular events (myocardial infarction, stroke) in patients with pre-existing disease
• Severe hypotension, especially when combined with nitrates
• Serotonin syndrome when taken with other serotonergic agents (e.g., other SSRIs, MAO inhibitors, tramadol)

Drug-Drug Interactions

• Nitrates - additive vasodilatory effect → dangerous hypotension.
• CYP3A4 inhibitors (ketoconazole, clarithromycin) - increase sildenafil plasma concentration → higher risk of adverse events.
• CYP3A4 inducers (rifampin, carbamazepine) - may reduce efficacy of sildenafil.
• Other serotonergic drugs - risk of serotonin syndrome; dose adjustment or avoidance recommended.

Drug-Food Interactions

• High-fat meals can delay sildenafil absorption, extending onset to 90-120 minutes.
• Alcohol may potentiate vasodilatory and hypotensive effects; moderate consumption is advised.

Use: Dosing, Missed Dose, Overdose

• Standard dose: One tablet (100 mg sildenafil/60 mg dapoxetine) taken orally 30-60 minutes before anticipated sexual activity. Do not exceed one tablet per 24-hour period.
• Missed dose: If sexual activity is not planned within 24 hours of the scheduled dose, simply skip the tablet and resume the normal dosing schedule at the next appropriate time. Do not double the dose to compensate.
• Overdose: Symptoms may include severe headache, hypotension, faintness, nausea, and prolonged erection. Seek immediate medical attention; supportive care is the mainstay of treatment.

Practical precautions

• Take the tablet with a glass of water; avoid crushing or chewing.
• Limit alcohol intake to ≤ 2 standard drinks per occasion.
• Refrain from operating heavy machinery or driving until you know how the medication affects you.
• Store below 30 °C, protected from moisture; keep out of reach of children.

FAQ

• What should I do if I experience a prolonged erection after taking Viagra with Dapoxetine? If an erection lasts longer than 4 hours, seek emergency medical care. Early intervention reduces the risk of permanent penile damage.

• Can I travel internationally with this medication? Yes, but keep the tablet in its original packaging with a copy of the prescription (if required) and declare it according to the destination country’s customs regulations.

• Does the tablet contain any allergens such as lactose or gluten? Formulations may include lactose, maize starch, or other excipients. Check the product’s patient information leaflet for a complete list of inactive ingredients.

• How long can I store the tablet after opening the bottle? Tablets are stable for up to 24 months when stored in a tightly closed container at room temperature away from humidity and direct sunlight.

• Is it safe to use the medication if I have mild renal impairment? Mild renal dysfunction does not usually require dose adjustment, but patients with moderate to severe renal disease should be evaluated by a clinician before use.

• Will taking Viagra with Dapoxetine affect hormone levels or fertility? Current evidence indicates no impact on testosterone, sperm count, or fertility when used as directed.

• Can I combine this medication with herbal supplements like ginkgo biloba? Ginkgo may potentiate the vasodilatory effect of sildenafil, increasing the risk of hypotension. Discuss any supplement use with a healthcare professional.

• Is there a generic version of this combination available in the United States? Yes. Several FDA-registered manufacturers produce the 100/60 mg combination as a generic product, which is often less expensive than brand-name equivalents.

• What is the difference between taking the combination tablet versus separate sildenafil and dapoxetine tablets? The combined tablet offers convenience and ensures synchronized dosing, whereas separate tablets require two timed administrations (sildenafil 30-60 minutes before sex and dapoxetine 1-2 hours before sex).

• How does food intake influence the effectiveness of Viagra with Dapoxetine? A high-fat meal can delay sildenafil absorption, potentially reducing its peak effect. Dapoxetine is less affected by food, but taking the tablet with a light meal may improve overall onset time.

Glossary

Phosphodiesterase-5 (PDE5) inhibitor

A class of drugs that block the PDE5 enzyme, preventing breakdown of cGMP and thereby promoting smooth-muscle relaxation in the penis.

Intravaginal Ejaculation Latency Time (IELT)

The measured interval from vaginal penetration to ejaculation; a key endpoint in premature-ejaculation studies.

Serotonin syndrome

A potentially life-threatening condition caused by excess serotonergic activity, presenting with agitation, hyperthermia, tremor, and autonomic instability.

Cytochrome P450 3A4 (CYP3A4)

A liver enzyme responsible for metabolizing many drugs, including sildenafil; inhibitors or inducers of CYP3A4 can alter drug concentrations.

Buying Viagra with Dapoxetine from Our Online Pharmacy

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Disclaimer

The information presented about Viagra with Dapoxetine is intended for general educational purposes and does not replace professional medical advice. All therapeutic decisions, including those involving off-label use, must be made under the supervision of a qualified healthcare professional. Readers are assumed to be responsible adults capable of making informed health choices. Our online pharmacy provides access to Viagra with Dapoxetine for individuals who may encounter limited availability through conventional pharmacies or insurance-based programs, or who are seeking cost-effective generic alternatives. Always discuss with your clinician before initiating, altering, or stopping any medication.