Generic Priligy (Dapoxetine)

Introduction

Priligy is a prescription-only oral medication that contains the selective serotonin reuptake inhibitor (SSRI) dapoxetine. It is formulated as a thin, film-coated tablet available in 30 mg, 60 mg, and 90 mg strengths. The drug is approved in the European Union, the United Kingdom, Canada, and several other jurisdictions for the treatment of premature ejaculation (PE) in adult men. Dapoxetine’s pharmacokinetic profile-rapid absorption, short half-life, and swift clearance-makes it suitable for on-demand use before sexual activity. In addition to its primary indication, dapoxetine has been investigated off-label for certain anxiety-related conditions, but such uses are not authorised by regulatory agencies.

What is Priligy?

Priligy is the trade name for a tablet that delivers the active compound dapoxetine. It belongs to the class of short-acting selective serotonin reuptake inhibitors (SSRIs) specifically developed for sexual-health indications. The product was first launched by pharmaceutical company Johnson & Johnson (through its subsidiary Janssen-Cilag) and subsequently received marketing authorisation in multiple regions. While Priligy is the branded formulation, the same molecule is marketed generically as dapoxetine, offering a cost-effective alternative for patients who qualify for therapy.

Priligy is the generic version of well-known medications, containing the active compound dapoxetine. Our online pharmacy provides this generic alternative as a cost-effective treatment option.

How Priligy Works

Dapoxetine selectively inhibits the re-uptake of serotonin (5-hydroxytryptamine) at neuronal synapses, increasing serotonergic tone in the central nervous system. Enhanced serotonin activity prolongs the latency to ejaculation by modulating spinal reflexes and central pathways that control ejaculatory control.

Key pharmacologic features:

• Onset: Peak plasma concentrations are reached within 1-2 hours after oral ingestion.
• Duration: The elimination half-life is approximately 1.5 hours, allowing the drug to be cleared rapidly after the sexual act.
• Clearance: Primarily hepatic metabolism via CYP2D6, with renal excretion of metabolites.

These characteristics enable patients to take a single dose 1-3 hours before intercourse, reducing the risk of cumulative side effects associated with longer-acting SSRIs.

Conditions Treated with Priligy

Premature Ejaculation (PE)

• Definition: A persistent or recurrent inability to delay ejaculation, resulting in a perceived ejaculatory latency of ≤ 1 minute in most sexual encounters.
• Rationale: By increasing serotonergic inhibition of the ejaculatory reflex, dapoxetine extends intravaginal ejaculatory latency time (IELT). Clinical trials demonstrate a statistically significant increase in IELT compared with placebo, leading to improved patient-reported control and satisfaction.

No other FDA- or EMA-approved pharmacologic treatments are available for on-demand use in PE, making dapoxetine the sole approved option.

Off-Label and Investigational Uses of Priligy

• Social Anxiety Disorder (SAD): Small open-label studies have explored short-acting SSRIs for situational anxiety. Dapoxetine’s rapid onset may provide temporary relief before stressful events, but robust randomized data are lacking.
• Female Sexual Dysfunction (FSD): Preliminary investigations evaluated dapoxetine for arousal disorders, yet efficacy and safety remain unconfirmed.

These applications are not approved by the FDA, EMA, or other major regulators. Any off-label use should be undertaken only under the direct supervision of a qualified healthcare professional, after a thorough risk-benefit assessment.

Is Priligy the Right Medication for You?

Priligy is appropriate for adult men who:

• Have a documented diagnosis of premature ejaculation based on clinical criteria.
• Seek on-demand treatment rather than continuous daily therapy.
• Do not have contraindications such as severe hepatic impairment, concurrent use of potent CYP2D6 inhibitors, or a history of cardiac arrhythmias.

Patients with cardiovascular disease, uncontrolled hypertension, or concurrent use of monoamine oxidase inhibitors (MAOIs) should avoid dapoxetine. Likewise, individuals taking other SSRIs, certain antihypertensives (e.g., pimozide), or tramadol should be evaluated for drug-drug interactions before initiating therapy.

Risks, Side Effects, and Interactions

Common

• Nausea
• Headache
• Dizziness
• Diarrhea

These effects are usually mild, transient, and resolve within a few hours after dosing.

Rare

• Insomnia
• Dry mouth
• Nasal congestion

While uncommon, these events may require dosage adjustment or symptomatic treatment.

Serious

• Syncope or fainting (especially when standing up quickly)
• Cardiac arrhythmias (e.g., QT prolongation) in patients with pre-existing heart conditions or when combined with drugs that affect cardiac conduction
• Serotonin syndrome if combined with other serotonergic agents (e.g., MAOIs, tramadol, triptans)

Medical attention should be sought immediately if any serious symptom occurs.

Drug-Drug Interactions

• CYP2D6 inhibitors (e.g., quinidine, fluoxetine, paroxetine) markedly increase dapoxetine plasma levels → dose reduction or avoidance.
• CYP3A4 inducers (e.g., rifampicin) may lower exposure → potential loss of efficacy.
• MAOIs contraindicated due to risk of serotonin syndrome.

Drug-Food Interactions

• Take with a light meal; high-fat meals delay absorption and may reduce efficacy.
• Alcohol may exacerbate dizziness and should be limited when using dapoxetine.

Use: Dosing, Missed Dose, Overdose

• Standard dosing: Start with 30 mg taken 1-3 hours before anticipated sexual activity. If well tolerated and insufficient effect, increase to 60 mg. The maximum recommended dose is 60 mg; some regions allow a 90 mg dose in specific cases under specialist supervision.
• Missed dose: If a dose is forgotten, do not take it later the same day. Take the next dose at the usual time before sexual activity.
• Overdose: In case of suspected overdose, seek emergency medical care. Symptoms may include severe nausea, vomiting, dizziness, and prolonged QT interval. Management is supportive, focusing on gastric decontamination and cardiac monitoring.

Practical precautions: Avoid operating heavy machinery or driving until you know how dapoxetine affects you. Alcohol consumption should be limited, as it can potentiate dizziness and impair judgment.

FAQ

• What is the recommended waiting period after taking Priligy before having sex?  The tablet should be ingested 1 to 3 hours prior to sexual activity. This window allows absorption, peak plasma concentration, and optimal therapeutic effect.

• Can I store Priligy tablets in a bathroom cabinet?  Tablets should be kept in a dry, cool place away from moisture and direct sunlight. A bathroom cabinet may have high humidity, which can degrade the tablet; a bedroom drawer or a medicine cabinet is preferable.

• Do different countries use different inactive ingredients in dapoxetine tablets?  Manufacturers may vary filler and binder components according to local regulatory requirements, but the active ingredient-dapoxetine-remains identical. Patients with known excipient allergies should verify the exact composition with the supplier.

• Is dapoxetine detectable on standard drug tests?  Standard workplace drug panels typically screen for substances of abuse (e.g., cannabinoids, opioids). Dapoxetine is not part of these panels and is unlikely to trigger a positive result.

• How does travel affect the stability of Priligy?  Short trips at ambient temperature (≤ 25 °C) pose no risk. Prolonged exposure to extreme heat (above 30 °C) or cold (below °C) may affect tablet integrity; store the medication in a temperature-controlled environment during travel.

• What color and imprint do the tablets have?  Priligy tablets are white, film-coated, and bear the imprint “30”, “60”, or “90” corresponding to their strength. The imprint aids identification and verification of authenticity.

• Can dapoxetine be taken with other SSRIs for depression?  Combining dapoxetine with another SSRI can significantly increase serotonin levels, raising the risk of serotonin syndrome. Co-administration is contraindicated unless under specialist supervision with dose adjustments.

• What is the difference between dapoxetine and longer-acting SSRIs like sertraline?  Dapoxetine has a much shorter half-life (≈ 1.5 h) and rapid clearance, allowing on-demand dosing. Longer-acting SSRIs have half-lives of 20-30 hours and require daily administration, making them unsuitable for PE treatment.

• Are there any special warnings for men with diabetes?  Diabetes itself does not contraindicate dapoxetine, but patients with autonomic neuropathy may have altered blood pressure responses. Monitoring for dizziness or fainting is advisable.

• How does dapoxetine interact with antihypertensive medications?  Certain antihypertensives (e.g., pimozide) can prolong the QT interval when combined with dapoxetine. Patients on such drugs should discuss alternatives with their physician.

• Is it safe to use dapoxetine in combination with herbal supplements like St. John’s wort?  St. John’s wort is a potent CYP2D6 inhibitor and can increase dapoxetine concentrations, potentially leading to adverse effects. Patients should disclose all supplement use to their prescriber.

Glossary

Selective serotonin reuptake inhibitor (SSRI)

A class of drugs that block the reabsorption of serotonin into neurons, increasing its availability in the brain and affecting mood and sexual function.

Intravaginal ejaculatory latency time (IELT)

The measured interval from vaginal penetration to ejaculation; a primary objective endpoint in premature ejaculation studies.

CYP2D6

An enzyme of the cytochrome P450 family responsible for metabolizing many drugs, including dapoxetine; genetic variations can affect drug levels.

QT prolongation

Extension of the heart’s electrical repolarization phase on an ECG, which can predispose to arrhythmias such as torsades de pointes.

Buying Priligy from Our Online pharmacy

Patients who have a valid prescription for dapoxetine can obtain the medication through our online pharmacy. Our service offers several advantages:

• Cost-effective pricing: We source the generic product close to manufacturer cost, reducing the financial burden compared with many brick-and-mortar pharmacies.
• Verified quality: All tablets are supplied by licensed, overseas pharmacies that comply with stringent Good Manufacturing Practice (GMP) standards.
• Discreet delivery: Packages are shipped in unmarked envelopes, with optional express delivery in 7 days or regular airmail arriving in ~3 weeks, ensuring privacy and reliability.
• International access: We act as a pharmacy-broker, partnering with reputable suppliers worldwide, which enables patients in regions with limited local availability to receive genuine dapoxetine.

Our platform respects patient confidentiality while providing a convenient, trustworthy route to obtain Priligy when traditional channels are inaccessible or unaffordable.

Disclaimer

The information presented about Priligy is intended solely for general educational purposes and does not replace personalized medical advice. Treatment choices, including considerations of off-label applications, must be made under the guidance of a qualified healthcare professional. Readers are assumed to be mature adults capable of making informed health decisions. Our online pharmacy supplies Priligy to individuals who may encounter barriers such as limited local pharmacy stock, insurance restrictions, or cost concerns, offering affordable generic alternatives. Prior to initiating, modifying, or discontinuing any medication, you should consult your physician.