--- title: Buy Phenergan Syrup (Promethazine) 100ml Online description: Phenergan Syrup (Promethazine) 100ml is a trusted treatment for allergies and motion sickness. Order from our secure pharmacy for reliable delivery. type: product language: en url: https://medsforsale.net/buy-phenergan-syrup-online-en availability: in_stock price_min: 24.99 price_max: 45.99 currency: USD offers: - name: 100ml x 1 bottle price: 24.99 - name: 100ml x 3 bottles price: 29.99 - name: 100ml x 2 bottles price: 29.99 - name: 100ml x 4 bottles price: 37.99 - name: 100ml x 5 bottles price: 45.99 --- # Buy Phenergan Syrup (Promethazine) 100ml Online Phenergan Syrup, containing the active ingredient Promethazine, is a well-established antihistamine developed by Wyeth Pharmaceuticals. It is used to relieve allergy symptoms, manage motion sickness, and provide sedative effects for nausea or insomnia. 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It belongs to the first-generation H₁-receptor antagonists and is indicated for the relief of allergy-related symptoms, prevention of motion-induced nausea, and control of postoperative nausea and vomiting. The product is supplied in 100 ml bottles and is manufactured by several licensed pharmaceutical companies worldwide. In addition to its approved uses, promethazine is sometimes employed off-label for conditions such as insomnia or migraine-related nausea, but such applications are not formally endorsed by the U.S. Food and Drug Administration (FDA) or the European Medicines Agency (EMA). --- ## What is Phenergan Syrup? Phenergan Syrup is a liquid medication that delivers the active compound promethazine in a concentration suited for oral administration. It is classified as a first-generation antihistamine with potent anticholinergic and sedative properties. Promethazine was first synthesized in the 194s and subsequently marketed under brand names such as Phenergan, Promethazine, and Prometex. Various manufacturers produce the syrup formulation, which is packaged in a 100 ml bottle for ease of dosing in adults and children who can swallow liquids. The syrup typically contains 5 mg of promethazine per millilitre, along with excipients such as sucrose, citric acid, flavoring agents, and preservatives that ensure palatability and stability. --- ## How Phenergan Syrup Works Promethazine blocks histamine H₁ receptors in peripheral tissues, preventing the cascade that leads to vasodilation, capillary permeability, and the classic symptoms of allergic reactions (itching, swelling, rhinorrhea). In the central nervous system, it antagonizes muscarinic acetylcholine receptors and exerts a depressant effect on the medullary vomiting center. This dual action reduces both the sensation of nausea and the reflex that triggers vomiting. Onset of therapeutic effect generally occurs within 15-30 minutes after oral ingestion, with peak plasma concentrations reached at about 1-2 hours. The drug’s half-life ranges from 10 to 19 hours, allowing for dosing every 4-6 hours while maintaining effective plasma levels. Metabolism occurs primarily in the liver via CYP2D6, and metabolites are eliminated renally. --- ## Conditions Treated with Phenergan Syrup - **Allergic Rhinitis and Urticaria** - By inhibiting H₁ receptors, promethazine alleviates itching, sneezing, watery eyes, and hives. - **Motion Sickness** - The central anti-emetic action dampens the vestibular inputs that provoke nausea during travel. - **Post-operative Nausea and Vomiting (PONV)** - Administered pre- or post-operatively, it reduces the incidence of nausea caused by anesthetic agents and opioid analgesics. - **Pre-operative Sedation** - The sedative property helps calm patients before minor surgical procedures. In each of these indications, the drug’s ability to block histamine and acetylcholine pathways directly tackles the pathophysiology of the symptom complex, providing rapid relief. --- ## Off-Label and Investigational Uses of Phenergan Syrup - **Insomnia** - Small clinical series have reported that low-dose promethazine improves sleep latency due to its antihistaminic sedation; however, safety for chronic use has not been established by regulatory bodies. - **Migraine-Associated Nausea** - Promethazine is sometimes added to migraine rescue regimens because its anti-emetic effect can complement triptans, though randomized controlled data are limited. - **Gastroparesis** - A few uncontrolled studies suggest benefit in reducing nausea and vomiting in diabetic gastroparesis, but the risk of anticholinergic side effects warrants caution. - **Palliative Care** - In oncology, promethazine is employed to control refractory nausea when standard anti-emetics fail, based on expert consensus rather than formal approval. These off-label applications should only be pursued under the direct supervision of a qualified healthcare professional, as the evidence base is less robust and the safety profile may differ from approved uses. --- ## Is Phenergan Syrup the Right Medication for You? Phenergan Syrup is most appropriate for adult patients who require rapid control of allergic symptoms, motion-induced nausea, or postoperative vomiting, and who do not have contraindications such as known hypersensitivity to phenothiazines. It is also useful in settings where a single agent can provide both antihistamine and anti-emetic effects, simplifying medication regimens. Contraindications include: - Children younger than 2 years (risk of severe respiratory depression). - Known allergy to promethazine, other phenothiazines, or any excipients in the syrup. - Patients with severe hepatic impairment or those taking monoamine oxidase inhibitors (risk of additive CNS depression). Pregnant women should avoid routine use; promethazine is classified as Pregnancy Category C, meaning risk cannot be ruled out. Lactating mothers are advised to consider the drug’s passage into breast milk and potential infant sedation. --- ## Risks, Side Effects, and Interactions ### Common - Drowsiness or sedation - Dry mouth - Dizziness or light-headedness - Blurred vision ### Rare - Extrapyramidal symptoms (tremor, rigidity) - Hypotension or orthostatic changes - Photophobia ### Serious - Respiratory depression, especially in children under 2 years or in patients with concurrent central depressants. - Severe allergic reactions (angio-edema, anaphylaxis). - Cardiac arrhythmias in patients with pre-existing conduction disorders. #### Drug-Drug Interactions - **CNS depressants** (opioids, benzodiazepines, alcohol): additive sedation and respiratory depression. - **Anticholinergic agents** (e.g., atropine, antihistamines): increased risk of anticholinergic toxicity (confusion, urinary retention). - **MAO inhibitors**: potential for heightened autonomic instability. - **Cytochrome P450 2D6 inhibitors** (e.g., fluoxetine, quinidine): may raise promethazine plasma concentrations, enhancing side-effects. Patients should disclose all current medications, including over-the-counter products and herbal supplements, before initiating therapy. --- ## Use: Dosing, Missed Dose, Overdose **Standard dosing for adults** (based on 5 mg/ml syrup): - **Allergy or motion sickness** - 12.5 mg (2.5 ml) every 4-6 hours as needed; maximum 100 mg (20 ml) per day. - **Post-operative nausea** - 12.5-25 mg (2.5-5 ml) 30 minutes before surgery, then every 4-6 hours post-operatively if required. **Missed dose:** If a scheduled dose is forgotten and the next dose is more than 4 hours away, take the missed dose. If the interval is less than 4 hours, skip the missed dose and resume the regular schedule. Do not double-dose to compensate. **Overdose:** Symptoms may include extreme drowsiness, respiratory depression, seizures, or coma. Immediate medical attention is essential. Activated charcoal may be considered if presentation is within one hour of ingestion, followed by supportive airway management and monitoring of vital signs. **Administration tips:** - Can be taken with or without food; a small amount of food may reduce gastric irritation. - Avoid alcohol and other sedatives while on promethazine. - Do not operate heavy machinery or drive until you know how the medication affects you. --- ## FAQ - **What is the sugar content of Phenergan Syrup?** - The formulation contains sucrose as a sweetening agent, providing roughly 5 g of sugar per 5 ml dose. Patients with diabetes should account for this in their carbohydrate plan. - **Can I store Phenergan Syrup in the refrigerator?** - Yes. The syrup remains stable at 2-8 °C (36-46 °F). If stored at higher temperatures, the shelf-life may be reduced, and the flavor could deteriorate. - **How long does an opened bottle remain usable?** - After opening, keep the bottle tightly sealed and use within 30 days. Discard any remaining product if it shows discoloration, precipitation, or an off-taste. - **Is promethazine safe for patients with glaucoma?** - Promethazine’s anticholinergic effects can increase intra-ocular pressure, potentially worsening narrow-angle glaucoma. Such patients should avoid the medication unless specifically authorized by an ophthalmologist. - **Does Phenergan Syrup interact with herbal supplements like St. John’s wort?** - St. John’s wort induces CYP3A4 but has minimal effect on CYP2D6, the primary enzyme for promethazine metabolism. Nevertheless, concurrent use should be discussed with a healthcare professional to monitor for unexpected sedation. - **Can Phenergan Syrup be taken during a fasting period for religious reasons?** - The syrup contains sugars and flavoring agents, so it would break a fast that prohibits caloric intake. Patients observing strict fasts may need to schedule dosing outside fasting windows. - **Why does the medication cause a metallic taste?** - Promethazine can alter taste perception by affecting salivary composition and mucosal receptors, leading to a transient metallic or bitter aftertaste. This effect usually lessens with continued use. - **Is it possible to develop tolerance to the sedative effect?** - Chronic daily use may lead to reduced drowsiness over time, but tolerance is unpredictable. If the sedative effect diminishes, dosage adjustments should be done only under professional guidance. - **What should I do if I experience severe drowsiness while driving?** - Pull over safely, refrain from operating the vehicle, and seek assistance. If the drowsiness persists, consider contacting a medical provider to evaluate dosing or alternative therapy. - **Can the syrup be used to treat allergic reactions in infants older than 2 years?** - Promethazine is not recommended for routine allergy treatment in children younger than 2 years because of the risk of respiratory depression. In children older than 2 years, dosing must be weight-based and supervised by a pediatric specialist. - **Does the medication affect laboratory test results?** - Promethazine can cause mild elevations in liver enzymes (ALT, AST) that are usually transient. It does not interfere significantly with common blood chemistry panels but may cause false-positive results in certain urine drug screens for phenothiazines. --- ## Glossary **Anticholinergic** : A drug property that blocks the action of acetylcholine at muscarinic receptors, leading to effects such as dry mouth, blurred vision, and reduced gastrointestinal motility. **First-generation antihistamine** : An older class of H₁-receptor blockers that cross the blood-brain barrier, causing sedation and anticholinergic side effects, unlike newer second-generation agents. **CYP2D6** : A liver enzyme belonging to the cytochrome P450 family, responsible for metabolizing many drugs, including promethazine. Variations in CYP2D6 activity can influence drug levels and side-effect risk. **Sedative-hypnotic** : A medication that induces calmness (sedation) and can promote sleep (hypnosis) by depressing central nervous system activity. --- ## Buying Phenergan Syrup from [our online pharmacy](https://medsforsale.net/buy-phenergan-syrup-online-en) Phenergan Syrup can be obtained through **[our online pharmacy](https://medsforsale.net/buy-phenergan-syrup-online-en)**, which specializes in delivering generic medicines at prices close to the manufacturer’s cost. We partner exclusively with licensed, overseas suppliers that meet rigorous quality-assurance standards, ensuring that each bottle is authentic, properly stored, and shipped in a discreet package. Patients who encounter limited local availability, high out-of-pocket expenses, or insurance barriers often find our service a reliable alternative. 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