Generic P Force (Sildenafil Citrate)

Introduction

P Force is a tablet formulation that contains the active pharmaceutical ingredient sildenafil citrate 100 mg. Sildenafil citrate belongs to the class of phosphodiesterase type 5 (PDE5) inhibitors and is used primarily to improve blood flow in specific vascular conditions. The medication is indicated for the treatment of erectile dysfunction (ED) and pulmonary arterial hypertension (PAH). Although marketed under the proprietary name P Force, the same active compound is found in well-known products such as Viagra and Revatio. The tablet is taken orally and is intended for adult patients who meet the clinical criteria for these approved indications.

What is P Force?

P Force is a branded oral tablet that delivers a single fixed dose of 100 mg sildenafil citrate. The product is manufactured by a pharmaceutical company that supplies generic and brand-name PDE5 inhibitors worldwide; the exact manufacturer is not disclosed in public sources.

• Classification: PDE5 inhibitor, vasodilator.
• Active ingredient: Sildenafil citrate, 100 mg per tablet.
• Formulation: Immediate-release solid oral dosage form.

P Force is the generic version of well-known medications, containing the active compound sildenafil citrate. Our online pharmacy provides this generic alternative as a cost-effective treatment option.

How P Force Works

Sildenafil citrate selectively inhibits the enzyme phosphodiesterase type 5 (PDE5). Under normal physiology, PDE5 breaks down cyclic guanosine monophosphate (cG → ). By blocking PDE5, sildenafil prolongs the action of cG → , which is generated in smooth-muscle cells of blood vessels in response to nitric oxide (NO). Elevated cG → leads to relaxation of vascular smooth muscle and vasodilation, thereby increasing blood flow to the corpus cavernosum of the penis and to the pulmonary vasculature.

• Onset: Clinical effect typically begins 30-60 minutes after ingestion.
• Duration: Efficacy can last 4-6 hours, with detectable plasma concentrations up to 12 hours.
• Clearance: Sildenafil is metabolized mainly by hepatic CYP3A4; the mean elimination half-life is about 4 hours.

These pharmacokinetic properties explain why the tablet is taken shortly before anticipated sexual activity or, for PAH, on a regular scheduled basis.

Conditions Treated with P Force

1. Erectile Dysfunction (ED) - The most common approved use. In men with insufficient penile erection due to inadequate arterial inflow, sildenafil’s vasodilatory effect enhances engorgement when sexual stimulation is present.

2. Pulmonary Arterial Hypertension (PAH) - In patients with elevated pulmonary arterial pressure, sildenafil reduces vascular resistance in the lung circulation, improving exercise capacity and delaying disease progression.

Both indications are supported by large, multicenter randomized controlled trials that demonstrated statistically significant improvements in validated outcome measures (e.g., International Index of Erectile Function for ED; six-minute walk distance for PAH).

Off-Label and Investigational Uses of P Force

Although regulatory agencies have not approved these applications, clinical research has explored additional potential benefits of sildenafil citrate:

• Raynaud’s Phenomenon: Small studies suggest vasodilatory action may reduce digital ischemia in severe cases.
• High-Altitude Pulmonary Edema (HAPE): Pilot trials indicate that sildenafil can lower pulmonary artery pressure in susceptible individuals climbing to high altitudes.
• Heart Failure with Preserved Ejection Fraction (HFpEF): Early phase II data propose improvement in exercise tolerance through pulmonary vasodilation.

These off-label uses remain investigational; efficacy and safety have not been definitively established, and they should only be pursued under direct supervision of a qualified healthcare provider.

Is P Force the Right Medication for You?

P Force is appropriate for adult patients who:

• Have a confirmed diagnosis of erectile dysfunction and are able to achieve sexual stimulation.
• Have a diagnosis of pulmonary arterial hypertension classified as WHO group 1 and require adjunctive oral therapy.

Clinical scenarios where P Force is especially recommended include men who have not responded to lifestyle modification alone, and PAH patients who need an oral agent complementary to endothelin-receptor antagonists or prostacyclin analogues.

Contraindications - P Force should not be used by individuals who:

• Are currently taking any nitrate medication (e.g., nitroglycerin, isosorbide dinitrate).
• Have severe uncontrolled hypertension or hypotension (systolic < 90 mmHg).
• Have a recent (< 6 months) history of stroke, myocardial infarction, or severe cardiac arrhythmia.
• Suffer from hereditary retinal disorders such as Leber’s congenital amaurosis.

Patients with moderate hepatic impairment may require dose adjustment, and those with severe renal dysfunction should use the medication with caution.

Risks, Side Effects, and Interactions

Common

• Headache
• Facial flushing
• Dyspepsia (indigestion)
• Nasal congestion
• Visual disturbances (e.g., blue-tinted vision, increased light sensitivity)

Rare

• Priapism (prolonged erection lasting > 4 hours)
• Sudden hearing loss or tinnitus
• Dermatologic reactions such as rash or pruritus

Serious

• Severe hypotension, especially when combined with nitrates or potent antihypertensives
• Myocardial ischemia or infarction in patients with underlying coronary artery disease
• Non-arteritic anterior ischemic optic neuropathy (vision loss)

Drug-Drug Interactions

• Nitrates (e.g., nitroglycerin): additive vasodilatory effect → life-threatening hypotension.
• Alpha-blockers (e.g., doxazosin): may cause symptomatic hypotension; start with low doses and monitor.
• CYP3A4 inhibitors (ketoconazole, itraconazole, ritonavir): increase sildenafil plasma levels → higher risk of adverse events.
• CYP3A4 inducers (rifampin, carbamazepine): reduce efficacy by lowering systemic exposure.

Drug-Food Interactions

• High-fat meals can delay absorption, reducing onset speed.
• Grapefruit juice may increase plasma concentrations due to CYP3A4 inhibition.

Use: Dosing, Missed Dose, Overdose

• Standard dosing for ED: Start with 50 mg taken as needed about 30 minutes before sexual activity; may increase to 100 mg or decrease to 25 mg based on efficacy and tolerability. Maximum recommended frequency is once per day.
• Standard dosing for PAH: Typically 20 mg three times daily; however, formulation and regional labeling may vary - always follow the prescribing information.

Missed Dose - If a dose is forgotten, take it as soon as remembered provided at least 4 hours have passed since the last dose. Do not double the dose to catch up.

Overdose - Symptoms may include severe hypotension, dizziness, prolonged erection, or visual changes. Seek immediate medical attention; supportive care (intravenous fluids, vasopressors) is the mainstay of treatment.

Practical Precautions

• Take the tablet with water; do not crush or chew.
• Avoid excessive alcohol, which can exacerbate hypotension and impair sexual performance.
• Refrain from operating heavy machinery or driving until you know how the medication affects you.

FAQ

• Can I travel internationally with P Force? Yes. The tablet is stable at room temperature for up to two years when stored in its original container. When crossing borders, keep the medication in its original packaging with the label visible to avoid customs complications.

• Does food affect the absorption of P Force? A high-fat meal can delay the time to maximum concentration by up to one hour, but it does not markedly change overall exposure. For the quickest effect, take the tablet on an empty stomach or after a light meal.

• What does the P Force tablet look like? The tablet is round, blue-colored, and bears the imprint “PF 100” on one side. Inactive ingredients typically include lactose, magnesium stearate, and microcrystalline cellulose, although exact excipients can vary by manufacturer.

• Are there any regional formulation differences for P Force? Some countries require additional compliance labeling or may use alternative binders to meet local pharmacopoeia standards. Nevertheless, the 100 mg strength and sildenafil citrate content remain consistent worldwide.

• Is a urine drug test affected by P Force? Sildenafil is not screened for in standard occupational drug tests because it is not a controlled substance. However, specialized testing can detect the compound if specifically requested.

• What is the half-life of sildenafil citrate? The mean elimination half-life is approximately 4 hours in healthy adults, allowing the drug to be cleared after about 24 hours with normal renal and hepatic function.

• How does P Force compare with older treatments for erectile dysfunction? Prior to PDE5 inhibitors, options included intra-urethral alprostadil or papaverine injections, which required invasive administration. Sildenafil offers oral convenience, a rapid onset, and a favorable safety profile, making it the first-line oral therapy in most guidelines.

• What clinical trials established the efficacy of sildenafil? The pivotal Phase III trials published in the New England Journal of Medicine (1998) demonstrated significant improvements in erection hardness and sexual satisfaction compared with placebo. Subsequent multicenter studies confirmed its benefit in PAH, leading to FDA approval for that indication under the brand Revatio.

• Is P Force safe for men over 65 years old? Older men can use sildenafil safely, but they often have comorbidities such as cardiovascular disease or renal impairment that may necessitate a lower starting dose (e.g., 25 mg). A thorough medical review is essential before initiating therapy.

• Can P Force be used in combination with other ED medications? Concurrent use of multiple PDE5 inhibitors is contraindicated due to the risk of severe hypotension and priapism. Combination with other classes, such as alprostadil, should only be considered under specialist guidance.

Glossary

Phosphodiesterase type 5 (PDE5) inhibitor

A drug class that blocks the PDE5 enzyme, preventing degradation of cyclic GMP and thereby promoting vasodilation in targeted vascular beds.

Pulmonary arterial hypertension (PAH)

A progressive disease characterized by high blood pressure in the arteries of the lungs, leading to right-heart strain and decreased exercise capacity.

Priapism

An erection lasting longer than four hours without sexual stimulation, which can cause permanent tissue damage if not promptly treated.

CYP450 enzymes

A family of liver enzymes, particularly CYP3A4, that metabolize many medications; inhibitors or inducers of these enzymes can alter drug concentrations.

Buying P Force from Our Online pharmacy

Patients who encounter limited availability of sildenafil citrate through traditional channels can obtain P Force from our online pharmacy. Our service sources the medication exclusively from licensed, audited suppliers, ensuring that each tablet meets stringent pharmaceutical quality standards at a price close to the manufacturer’s cost.

• Affordability: By operating as a pharmacy-broker service, we reduce markup and pass the savings directly to you, offering a cost-effective alternative to brand-name products.
• Verified quality: All inventory is batch-tested and accompanied by a full chain-of-custody documentation, guaranteeing authenticity and potency.
• Discrete delivery: Orders are packaged in neutral, unmarked parcels and shipped via secure carriers, typically arriving within 7 days for express options or 3 weeks for standard air mail.
• Global access: Our platform connects you with overseas licensed pharmacies, making the medication reachable even in regions where local supply is constrained.

By choosing our online pharmacy, you benefit from a reliable, private, and economical way to access P Force, supporting continuity of care when other avenues are unavailable.

Disclaimer

The information presented about P Force is intended for general educational purposes only and does not replace professional medical consultation. All therapeutic decisions, including the consideration of off-label applications, should be made under the direct supervision of a qualified healthcare provider. Readers are assumed to be competent adults capable of assessing health-related information responsibly. Our online pharmacy offers access to P Force for individuals who may encounter limited availability through conventional pharmacies or who are seeking affordable generic alternatives. Prior to initiating, modifying, or discontinuing any medication, you should always seek advice from a qualified medical professional.