Generic Levitra With Dapoxetine (Vardenafil with Dapoxetine)

Introduction

Levitra with Dapoxetine is a fixed-dose oral tablet that combines the phosphodiesterase-5 (PDE5) inhibitor vardenafil with the selective serotonin-reuptake inhibitor (SSRI) dapoxetine. The product is intended for adult males who experience erectile dysfunction (ED) and concurrent premature ejaculation (PE). It is supplied as a 20 mg/60 mg tablet, representing the standard strength used in clinical trials. The combination aims to provide rapid erection (via vardenafil) while extending ejaculation latency (via dapoxetine). While the primary indication is the concurrent treatment of ED and PE, clinicians sometimes discuss off-label applications in sexual-performance counseling under strict medical supervision.

What is Levitra with Dapoxetine?

Levitra with Dapoxetine is a generic formulation that contains the active ingredients vardenafil and dapoxetine. Vardenafil is the key component of the well-known brand Levitra, while dapoxetine is marketed in several countries under the brand name Priligy for premature ejaculation. The tablet is produced by licensed manufacturers that follow Good Manufacturing Practice (GMP) standards. Our online pharmacy offers this combined generic product as a cost-effective alternative to branded combinations.

How Levitra with Dapoxetine Works

• Vardenafil binds to the PDE5 enzyme in the smooth muscle of the corpus cavernosum. Inhibition of PDE5 prevents the breakdown of cyclic guanosine monophosphate (cGMP), allowing nitric oxide-mediated vasodilation. This results in increased blood flow to the penis after sexual stimulation. Onset of action is typically 30 minutes, with a therapeutic window of up to 4-5 hours.
• Dapoxetine selectively blocks the reuptake of serotonin at neuronal synapses, increasing serotonergic tone. Elevated serotonin delays the ejaculatory reflex, extending intravaginal ejaculation latency time (IELT). Dapoxetine has a short plasma half-life of about 1-2 hours, allowing on-demand dosing about 1-2 hours before sexual activity.

The synchronized pharmacokinetics of both agents enables a single tablet to address two distinct aspects of male sexual function: erection quality and ejaculation control.

Conditions Treated with Levitra with Dapoxetine

Clinical trials of the vardenafil/dapoxetine combination have demonstrated statistically significant improvements in both International Index of Erectile Function (IIEF) scores and intravaginal ejaculation latency time compared with monotherapy.

Off-Label and Investigational Uses of Levitra with Dapoxetine

• Treatment of Male Sexual Dysfunctions Related to Anxiety: Small pilot studies suggest that the serotonergic effect of dapoxetine may reduce performance anxiety, thereby indirectly supporting erectile function.
• Adjunct in Counseling for Sexual Trauma Survivors: Some clinicians have reported using the combination to aid patients recovering from psychogenic erectile difficulties, though robust data are lacking.

These applications have not received regulatory approval from the FDA, EMA, or comparable agencies. Patients should only consider off-label use after a thorough evaluation by a qualified healthcare professional, as safety and efficacy have not been formally established for these contexts.

Is Levitra with Dapoxetine the Right Medication for You?

• Suitable Patients: Adult men (≥18 years) diagnosed with both ED and PE, who have not responded adequately to monotherapy, are prime candidates.
• Clinical Scenarios Favoring Combination Therapy: When the patient reports satisfactory erection with PDE5 inhibitors but experiences early ejaculation, or vice versa, the combined tablet may streamline treatment.
• Contraindications:
  • Use of nitrates (e.g., nitroglycerin) or nitric-oxide donors.
  • Severe hepatic impairment (dapoxetine metabolism).
  • Uncontrolled hypertension or recent cardiovascular events.
  • Concomitant use of potent CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin).

Patients with these conditions should discuss alternative therapies with their provider.

Risks, Side Effects, and Interactions

Common

• Headache
• Flushing
• Nasal congestion
• Dyspepsia (indigestion)
• Transient visual disturbances (e.g., altered color perception)

Rare

• Priapism (prolonged erection lasting >4 hours)
• Allergic skin reactions (rash, pruritus)
• Hypertension or hypotension unrelated to nitrate use

Serious

• Cardiovascular events (myocardial infarction, stroke) in patients with pre-existing heart disease
• Severe hypotension when combined with nitrates

Drug-Drug Interactions

• Nitrates: Co-administration can cause dangerous hypotension.
• CYP3A4 inhibitors (e.g., ketoconazole, erythromycin): May increase vardenafil plasma levels, heightening side-effect risk.
• CYP2D6 inhibitors (e.g., fluoxetine, paroxetine): Can raise dapoxetine concentrations, increasing risk of serotonin-related adverse events.

Drug-Food Interactions

• High-fat meals may delay vardenafil absorption, postponing onset of action.
• Excessive alcohol can potentiate vasodilatory effects, leading to dizziness or hypotension.

Patients should avoid excessive alcohol and large fatty meals shortly before taking the tablet.

Use: Dosing, Missed Dose, Overdose

• Standard Dosing: The recommended starting dose is one 20 mg/60 mg tablet taken approximately 1 hour before sexual activity. The dose may be increased to 40 mg/60 mg based on efficacy and tolerability. Do not exceed one tablet per 24 hours.
• Missed Dose: Because the medication is taken on demand, there is no “daily” schedule. If a dose is forgotten, take it as soon as sexual activity is anticipated. Do not exceed the recommended maximum dose.
• Overdose: In case of accidental ingestion of more than one tablet, seek immediate medical attention. Symptoms may include severe hypotension, prolonged erection, or intense headache.
• Practical Precautions:
  • Take the tablet with water; food is optional but high-fat meals may delay effect.
  • Avoid driving or operating machinery if you experience dizziness or visual changes.
  • Limit alcohol intake to moderate levels (≤2 standard drinks) to reduce cardiovascular stress.

FAQ

• What is the typical time to onset of effect for Levitra with Dapoxetine?   The vardenafil component usually begins working within 30 minutes, while dapoxetine reaches peak plasma concentrations 1-2 hours after ingestion. Patients often experience full effect when the tablet is taken about 1 hour before planned sexual activity.

• Can the tablet be stored in a humid climate without degrading?   The tablet should be kept in a dry, controlled environment at temperatures between 15 °C and 30 °C (59 °F-86 °F). Excessive humidity or heat can affect tablet integrity, so a sealed container away from moisture is recommended.

• Is the tablet’s appearance standardized across manufacturers?   Generic versions of vardenafil/dapoxetine are typically round, blue-ish tablets with "20/60" imprinted, but minor variations in shape or color can occur depending on the supplier. The imprint and dosage information remain consistent for safety.

• Does dapoxetine appear on standard drug tests for employment?   Dapoxetine is not a controlled substance and is not routinely screened for in standard occupational drug panels. However, specialized testing can detect its presence if specifically requested.

• Are there any age-related dosing adjustments for older adults?   Patients over 65 years should start at the lowest dose (20 mg/60 mg) and assess tolerance before considering a higher dose, due to potential changes in hepatic metabolism and cardiovascular risk.

• How does the combination compare to taking vardenafil and dapoxetine separately?   Using a single fixed-dose tablet simplifies treatment, improves adherence, and ensures synchronized pharmacokinetics. Separate administration may require precise timing to achieve optimal synergy, which the combination tablet eliminates.

• Can the tablet be used in patients with diabetes?   Diabetic men with vascular disease may benefit from vardenafil’s vasodilatory effects, but they should be evaluated for cardiovascular risk before initiating therapy. Dapoxetine’s efficacy is not impaired by diabetes.

• What are the storage requirements for travel abroad?   When traveling, keep the tablet in its original packaging, protected from direct sunlight and extreme temperatures. A small insulated pouch can maintain stable conditions during flights or long car journeys.

• Does the tablet have any known contraindication for patients with psychiatric disorders?   Patients taking monoamine oxidase inhibitors (MAOIs) or those with severe depression should avoid dapoxetine due to the risk of serotonin syndrome. Consultation with a mental-health professional is advisable.

• Is there any evidence that the combination improves sexual satisfaction beyond physiological measures?   Patient-reported outcome studies have shown that simultaneous improvement in erection quality and ejaculation control can enhance overall sexual confidence and satisfaction, though individual experiences vary.

Glossary

Phosphodiesterase-5 (PDE5) Inhibitor

A class of drugs that block the enzyme responsible for breaking down cGMP, thereby facilitating penile erection when sexual stimulation occurs.

Serotonin-Reuptake Inhibitor (SRI)

A medication that increases serotonin levels in the brain by preventing its reabsorption into neurons; dapoxetine is a short-acting SRI used for premature ejaculation.

Intravaginal Ejaculation Latency Time (IELT)

The measured interval from vaginal penetration to ejaculation; a primary endpoint in clinical trials of premature ejaculation therapies.

CYP450 Enzymes

A family of liver enzymes (e.g., CYP3A4, CYP2D6) that metabolize many drugs; inhibitors or inducers of these enzymes can alter drug plasma levels.

Buying Levitra with Dapoxetine from Our Online pharmacy

Accessing a combined vardenafil/dapoxetine tablet can be challenging through conventional pharmacies, especially when insurance coverage is limited or the product is not stocked locally. Our online pharmacy offers a reliable pathway to obtain this medication discreetly and affordably.

• Cost Efficiency: Because we source the generic formulation directly from licensed manufacturers, the price is close to the product’s production cost, reducing the financial burden on patients.
• Verified Quality: All tablets are procured from GMP-certified facilities and are subject to third-party testing for potency and purity, ensuring that you receive a safe, pharmaceutical-grade product.
• Secure Delivery: Orders are packaged in unbranded, tamper-evident envelopes and shipped via trusted carriers. Standard express delivery reaches most regions within 7 days, while regular airmail typically arrives in 2-3 weeks.
• Privacy Assurance: Our pharmacy broker service operates under strict confidentiality protocols. We do not disclose purchase details, and billing documents are generic, preserving your privacy throughout the transaction.

For patients who lack local access or who prefer a straightforward, cost-effective solution, our online pharmacy serves as a dependable partner in managing sexual health needs.

Disclaimer

The information presented about Levitra with Dapoxetine is intended for general educational purposes and does not replace personalized medical advice. Decisions regarding therapy-including off-label applications-should be made under the guidance of a qualified healthcare professional. Readers are presumed to be competent adults capable of informed health decisions. Our online pharmacy provides access to Levitra with Dapoxetine for individuals encountering limited availability through conventional pharmacies or seeking affordable generic options. Always consult your physician before initiating, modifying, or discontinuing any medication.