Fildena (Sildenafil Citrate)

Introduction

Fildena is a oral tablet that contains the phosphodiesterase-5 (PDE5) inhibitor sildenafil citrate. It is manufactured as a 100 mg pill and belongs to the class of erectile dysfunction (ED) medicines. The medication is approved in many jurisdictions for the treatment of erectile dysfunction in adult men and, under separate brand names, for pulmonary arterial hypertension (PAH). In addition to its primary indication, clinicians sometimes discuss off-label applications such as the management of certain forms of secondary hypertension or high-altitude adaptation, although these uses have not received regulatory approval.

What is Fildena?

Fildena is a generic formulation of sildenafil citrate, the active ingredient first approved as the prescription drug Viagra® for erectile dysfunction and later as Revatio® for pulmonary arterial hypertension. The tablet is produced by several licensed manufacturers and distributed worldwide. Our online pharmacy supplies this generic alternative, providing a cost-effective option that contains the same pharmacologically active compound as the brand-name products.

How Fildena Works

Sildenafil citrate selectively blocks the enzyme phosphodiesterase-5, which normally degrades cyclic guanosine monophosphate (cGMP) in the smooth muscle of the penis and pulmonary vasculature. By inhibiting PDE5, Fildena allows cGMP to accumulate, promoting relaxation of smooth muscle cells and vasodilation. In the corpus cavernosum this results in increased blood flow during sexual stimulation, producing an erection. In the pulmonary arteries the same mechanism lowers vascular resistance, improving exercise capacity in PAH. Oral absorption is rapid, with peak plasma concentrations reached within 30-120 minutes. The biological half-life is approximately 4 hours, and the drug is eliminated primarily via hepatic metabolism (CYP3A4) and renal excretion.

Conditions Treated with Fildena

• Erectile Dysfunction (ED) - Fildena is approved for the treatment of men who experience difficulty achieving or maintaining an erection sufficient for satisfactory sexual performance. The drug’s ability to amplify the natural nitric-oxide-cGMP pathway directly addresses the physiological cause of most ED cases.
• Pulmonary Arterial Hypertension (PAH) - Under the name Revatio®, sildenafil citrate is indicated for PAH, a progressive disease characterized by elevated pressure in the pulmonary arteries. Vasodilation of the pulmonary vasculature reduces right-ventricular strain and improves functional capacity.

Both indications are supported by large, randomized, placebo-controlled trials demonstrating improvements in erection quality (International Index of Erectile Function scores) and six-minute walk distance for PAH patients.

Off-Label and Investigational Uses of Fildena

• Benign Prostatic Hyperplasia (BPH) Symptoms - Small clinical studies suggest that PDE5 inhibition may reduce lower-urinary-tract symptoms by relaxing smooth muscle in the prostate and bladder neck.
• High-Altitude Pulmonary Edema (HAPE) Prophylaxis - Preliminary research indicates sildenafil may prevent hypoxia-induced pulmonary vasoconstriction in climbers, decreasing the risk of HAPE.
• Raynaud’s Phenomenon - Case series have reported improvement in digital blood flow with sildenafil, though evidence remains limited.

These applications have not been approved by the U.S. Food and Drug Administration (FDA) or the European Medicines Agency (EMA). Patients considering any off-label use should do so only under direct supervision of a qualified healthcare professional, because safety and efficacy have not been formally established.

Is Fildena the Right Medication for You?

Fildena is suitable for adult men with a clinical diagnosis of erectile dysfunction who have not responded adequately to lifestyle modifications. It is also indicated for men with PAH when prescribed by a specialist. The medication works best when the patient has adequate sexual stimulation, as it does not initiate an erection without neural input.

Contraindications include:

• Concurrent use of nitrates (e.g., nitroglycerin) or nitric-oxide donors, due to risk of profound hypotension.
• Severe cardiovascular disease (unstable angina, recent myocardial infarction, or uncontrolled hypertension).
• Known hypersensitivity to sildenafil or any tablet excipients.

Patients with moderate renal or hepatic impairment may require dose adjustment, and those with certain genetic CYP3A4 variations may experience altered drug exposure.

Risks, Side Effects, and Interactions

Common

• Headache
• Flushing
• Dyspepsia (indigestion)
• Nasal congestion
• Visual disturbances (e.g., blue-tinted vision)

These events are usually mild, transient, and resolve without medical intervention.

Rare

• Priapism (erection lasting > 4 hours)
• Sudden hearing loss
• Myalgia or back pain lasting several days

If any rare symptom persists or worsens, medical evaluation is advised.

Serious

• Severe hypotension, especially when combined with nitrates or alpha-blockers
• Cardiovascular events (myocardial infarction, stroke) in patients with pre-existing heart disease
• Vision loss due to non-arteritic anterior ischemic optic neuropathy (NAION)

Patients experiencing serious adverse events should seek urgent medical care.

Drug-Drug Interactions

• Nitrates (e.g., nitroglycerin, isosorbide dinitrate): potentiate vasodilatory effects → risk of life-threatening hypotension.
• Alpha-blockers (e.g., doxazosin, tamsulosin): additive blood pressure lowering; start Fildena at lower dose and monitor.
• CYP3A4 inhibitors (e.g., ketoconazole, erythromycin, protease inhibitors): increase sildenafil plasma concentrations → consider dose reduction.
• CYP3A4 inducers (e.g., rifampin, carbamazepine): decrease effectiveness; may require higher dose under supervision.

Drug-Food Interactions

• High-fat meals can delay absorption, reducing the onset of action by up to 1 hour.

Alcohol

• Moderate alcohol consumption may exacerbate hypotensive effects; excessive intake is discouraged.

Use: Dosing, Missed Dose, Overdose

Standard dosing for erectile dysfunction starts with one 100 mg tablet taken as needed, approximately 30-60 minutes before sexual activity. The dose may be adjusted to 50 mg or 150 mg based on efficacy and tolerability, but should not exceed one tablet per 24-hour period.

For pulmonary arterial hypertension, the typical regimen is 20 mg taken three times daily, spaced evenly (approximately every 8 hours).

Missed dose: If a dose is missed for the ED indication and sexual activity is still anticipated within the next 24 hours, take the tablet as soon as possible. Do not exceed one dose per day. For PAH, take the missed dose as soon as remembered unless it is within 4 hours of the next scheduled dose; then skip the missed tablet and resume the regular schedule.

Overdose: Signs of overdose include severe hypotension, prolonged erection, or chest pain. If overdose is suspected, seek emergency medical attention promptly. Supportive care-intravenous fluids, vasopressors, and monitoring-may be required.

Administration advice: The tablet can be swallowed whole with water; it may be taken with or without food, noting that a fatty meal can delay onset. Avoid operating heavy machinery or driving until the full effect of the medication is known, especially if experiencing dizziness or visual changes.

FAQ

• What should I do with Fildena if I travel internationally?   Store the tablets in a cool, dry place away from direct sunlight. Most airlines allow personal medication in carry-on baggage, but keep the original packaging and any supporting documentation to avoid customs questions.

• Can I take Fildena if I have a mild liver condition?   Mild hepatic impairment generally does not require dose adjustment, but it is advisable to discuss any liver disease with a healthcare provider before starting therapy.

• How does the appearance of a Fildena tablet differ from brand-name Viagra?   Fildena tablets are typically round, blue-colored, and bear a 100 mg imprint; Viagra tablets are diamond-shaped and bear a distinct imprint code. Inactive ingredients may also differ, affecting tolerability in patients with specific allergies.

• Is it safe to store Fildena in a bathroom cabinet?   Bathrooms can experience high humidity, which may degrade the tablet’s stability over time. A dry drawer or a cabinet away from moisture is preferable for long-term storage.

• Does taking Fildena affect drug testing for employment?   Standard occupational drug screens do not test for sildenafil. However, specialized testing could detect the drug; patients with concerns should disclose any prescribed medication to the testing facility.

• Can Fildena be used by men with diabetes?   Diabetic men often experience endothelial dysfunction, and sildenafil has been shown to improve erectile function in this population. Nonetheless, cardiovascular status should be evaluated before therapy, as diabetes can increase the risk of heart disease.

• What are the differences between the 50 mg, 100 mg, and 150 mg strengths?   Lower doses may be adequate for men who respond well or who are sensitive to side effects. Higher doses can increase efficacy but also raise the likelihood of adverse events. The optimal dose is individualized based on response and tolerability.

• How long does Fildena remain detectable in the body?   Sildenafil’s half-life is about 4 hours, but trace amounts can be identified in plasma for up to 24 hours and in urine for up to 48 hours after a single dose.

• Is there a risk of developing tolerance to Fildena?   Current evidence does not support the development of pharmacological tolerance with intermittent use. Continuous daily dosing for PAH is managed differently, with monitoring for sustained efficacy.

• Does Fildena interact with herbal supplements such as Ginkgo biloba?   Ginkgo biloba can have mild antiplatelet activity and, in rare reports, may potentiate the hypotensive effect of sildenafil. Patients using such supplements should discuss potential interactions with their clinician.

Glossary

Phosphodiesterase-5 (PDE5) Inhibitor

A class of drugs that block the PDE5 enzyme, preventing breakdown of cGMP and thereby promoting smooth-muscle relaxation and vasodilation.

cGMP (Cyclic Guanosine Monophosphate)

A secondary messenger that mediates nitric-oxide-induced smooth-muscle relaxation; increased levels lead to enhanced blood flow.

Pulmonary Arterial Hypertension (PAH)

A progressive condition characterized by abnormally high blood pressure in the arteries that supply the lungs, leading to right-heart strain.

Buying Fildena from Our Online Pharmacy

Fildena is readily available through our online pharmacy, which specializes in delivering verified generic medications worldwide. By sourcing directly from licensed overseas suppliers, we can offer the tablet at a price that approaches manufacturer cost, helping patients manage the financial burden of long-term therapy.

All shipments are fulfilled by reputable, fully accredited pharmacies that follow Good Manufacturing Practice (GMP) standards, ensuring each tablet meets rigorous quality criteria. Discreet packaging and secure courier services protect privacy, and most orders arrive within 7 days for express delivery or roughly 3 weeks via regular airmail, depending on destination.

Our service operates as a pharmacy-broker model, bridging the gap between patients who may lack local access to affordable generic sildenafil and the global supply chain. The process is straightforward, secure, and designed to respect the confidentiality of every individual who chooses to obtain Fildena through our platform.

Disclaimer

The material presented about Fildena is intended for general informational purposes and does not substitute professional medical advice. Treatment choices, including any off-label applications, should be made under the supervision of a qualified healthcare provider. Readers are presumed to be competent adults capable of making informed health decisions. Our online pharmacy provides access to Fildena for individuals who might encounter limited availability through conventional pharmacies or insurance programs, or who are seeking a cost-effective generic option. Always consult a medical professional before initiating, modifying, or stopping any medication.