Fildena Extra Power (Sildenafil Citrate)

Introduction

Fildena Extra Power is a medication primarily used in the management of erectile dysfunction (ED) in adult men. It contains the active pharmaceutical ingredient Sildenafil Citrate, which belongs to a class of drugs known as phosphodiesterase type 5 (PDE5) inhibitors. While widely recognized for its role in treating ED, Sildenafil Citrate is also approved for the treatment of pulmonary arterial hypertension (PAH) in some formulations. This article provides an evidence-based overview of Fildena Extra Power, explaining its mechanism of action, approved uses, potential off-label applications, and important safety considerations for patients in English-speaking regions.

What is Fildena Extra Power?

Fildena Extra Power is the generic version of well-known medications, containing the active compound Sildenafil Citrate. Our online pharmacy provides this generic alternative as a cost-effective treatment option. Sildenafil Citrate was originally developed by Pfizer and first gained approval in 1998. It is marketed under brand names such as Viagra for erectile dysfunction and Revatio for pulmonary arterial hypertension. Fildena Extra Power, like other generic versions, contains the same active ingredient, Sildenafil Citrate, and is manufactured to meet the same quality and efficacy standards as the branded product. It is classified as a PDE5 inhibitor, a medication group that works by specifically targeting an enzyme involved in blood flow regulation.

How Fildena Extra Power Works

The primary mechanism of action of Fildena Extra Power, owing to its Sildenafil Citrate content, involves the selective inhibition of phosphodiesterase type 5 (PDE5). In the context of erectile dysfunction, sexual stimulation leads to the local release of nitric oxide (NO) in the penis. Nitric oxide activates the enzyme guanylate cyclase, which in turn increases the levels of cyclic guanosine monophosphate (cGMP). cGMP is responsible for relaxing the smooth muscles in the corpus cavernosum of the penis, allowing for increased blood flow and resulting in an erection.

PDE5 is an enzyme that degrades cGMP, thereby terminating the erectile response. By inhibiting PDE5, Sildenafil Citrate prevents the breakdown of cGMP, leading to sustained smooth muscle relaxation and enhanced blood flow during sexual arousal. This facilitates the achievement and maintenance of an erection. It is important to note that Sildenafil Citrate does not cause an erection directly; sexual stimulation is still required for the drug to be effective. The onset of action is typically within 30 to 60 minutes, and its effects can last for approximately 4 to 5 hours. The drug is primarily metabolized in the liver by cytochrome P450 enzymes (specifically CYP3A4 and CYP2C9) and excreted predominantly in the feces, with a smaller proportion in the urine.

Conditions Treated with Fildena Extra Power

Fildena Extra Power, containing Sildenafil Citrate, is primarily indicated for the treatment of:

• Erectile Dysfunction (ED): This condition is characterized by the inability to achieve or maintain an erection firm enough for satisfactory sexual intercourse. Sildenafil Citrate effectively treats ED by enhancing the natural erectile response to sexual stimulation, as explained by its mechanism of PDE5 inhibition. By increasing blood flow to the penis, it helps men achieve and sustain erections, thereby improving sexual function and quality of life.

While Fildena Extra Power is specifically formulated and marketed for ED, Sildenafil Citrate in other formulations is also approved for:

• Pulmonary Arterial Hypertension (PAH): This is a rare and progressive disease characterized by high blood pressure in the arteries leading to the lungs. Sildenafil, when prescribed for PAH (often under the brand name Revatio), works by relaxing the smooth muscle cells in the pulmonary arteries, reducing pressure, and improving exercise capacity and delaying clinical worsening. This effect is also mediated by PDE5 inhibition, which is present in both the pulmonary vasculature and the penile tissue.

Off-Label and Investigational Uses of Fildena Extra Power

While Fildena Extra Power is specifically approved for erectile dysfunction, its active ingredient, Sildenafil Citrate, has been explored for various off-label or investigational uses. It is crucial to understand that these uses are not officially approved by regulatory bodies like the FDA or EMA, and their efficacy and safety for these conditions have not been fully established. Any consideration of off-label treatment should only be undertaken under the direct supervision of a qualified healthcare provider.

• Raynaud's Phenomenon: Clinical studies suggest that Sildenafil Citrate may be beneficial in treating severe Raynaud's phenomenon, a condition causing reduced blood flow to the fingers and toes, often triggered by cold temperatures or stress. Its vasodilatory properties, achieved through PDE5 inhibition, can help improve blood flow to constricted vessels, potentially reducing the frequency and severity of attacks.
• High-Altitude Pulmonary Edema (HAPE): Sildenafil Citrate is sometimes used in clinical practice for the prevention and treatment of HAPE, a life-threatening condition that can occur at high altitudes. Its ability to dilate pulmonary arteries and reduce pulmonary pressure can help alleviate the symptoms and progression of this condition.
• Female Sexual Dysfunction (FSD): Research into the use of Sildenafil Citrate for various forms of FSD has been conducted, particularly concerning arousal disorders. The rationale is that by increasing blood flow to the clitoral and vaginal tissues, it might enhance arousal and sensation. However, results have been mixed, and it is not generally recommended for FSD due to inconsistent efficacy and potential side effects.
• Heart Failure with Preserved Ejection Fraction (HFpEF): Some investigational studies have explored Sildenafil's role in improving exercise capacity and hemodynamics in patients with HFpEF. The rationale is based on its vasodilatory effects and potential to improve cardiac function, though definitive clinical benefits are still under investigation.

It is paramount to reiterate that off-label use should always be discussed with a healthcare professional, as they can assess the potential benefits against the risks for an individual patient.

Is Fildena Extra Power the Right Medication for You?

Fildena Extra Power, containing Sildenafil Citrate, is primarily suitable for adult men diagnosed with erectile dysfunction who are otherwise in good cardiovascular health. It is particularly recommended for individuals where the underlying cause of ED is primarily vascular in nature, or when other contributing factors such as psychological stress or chronic diseases (e.g., diabetes, hypertension) have been identified and managed.

However, Fildena Extra Power may not be appropriate for everyone. Contraindications include:

• Concurrent use of nitrates: Patients taking any form of organic nitrates (e.g., nitroglycerin, isosorbide dinitrate) for chest pain or heart conditions should not use Sildenafil Citrate, as this combination can cause a dangerous drop in blood pressure.
• Severe cardiovascular disease: Individuals with severe heart problems, unstable angina, recent myocardial infarction (heart attack) or stroke, or uncontrolled high or low blood pressure may be advised against using Sildenafil Citrate due to the potential cardiovascular strain.
• Severe liver or kidney impairment: Dosage adjustments or avoidance may be necessary in patients with significant hepatic or renal dysfunction.
• Known hypersensitivity: Patients with a history of allergic reactions to Sildenafil or any other component of the medication should avoid its use.
• Certain eye conditions: Individuals with a history of non-arteritic anterior ischemic optic neuropathy (NAION), a condition causing sudden vision loss, should use Sildenafil Citrate with caution, as it has been rarely associated with this condition.

A thorough medical evaluation, including a review of medical history and current medications, is essential before considering Fildena Extra Power to ensure it is safe and appropriate for your specific health profile.

Risks, Side Effects, and Interactions

Like all medications, Fildena Extra Power can cause side effects and interact with other substances. Understanding these is crucial for safe use.

Common Adverse Events

These side effects are generally mild and transient, affecting more than 1 in 100 people:

• Headache: The most frequently reported side effect.
• Flushing: A sensation of warmth or redness, particularly in the face and neck.
• Dyspepsia: Indigestion or heartburn.
• Nasal congestion: A stuffy nose.
• Visual disturbances: Including blurred vision, sensitivity to light, or a temporary blue tinge to vision.
• Dizziness: A feeling of lightheadedness.

Rare Adverse Events

These affect fewer than 1 in 100 people and may require medical attention:

• Rash: Skin eruptions.
• Muscle pain (myalgia): Aches or discomfort in the muscles.
• Back pain: Discomfort in the lower back.
• Palpitations: Awareness of one's own heartbeat.
• Eye irritation/redness: Discomfort or discoloration of the eyes.

Serious Adverse Events

These are uncommon but require immediate medical attention:

• Priapism: A prolonged erection lasting more than 4 hours. This is a medical emergency and can cause permanent damage to the penis if not treated promptly.
• Sudden decrease or loss of vision: This can be a sign of non-arteritic anterior ischemic optic neuropathy (NAION), a serious eye condition.
• Sudden decrease or loss of hearing: This can occur rarely and should be reported immediately.
• Chest pain or heart attack symptoms: If experienced during sexual activity, seek emergency medical care.
• Severe allergic reactions: Including rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, or trouble breathing.

Drug-Drug Interactions

Sildenafil Citrate interacts significantly with several classes of medications:

• Nitrates: Concomitant use with organic nitrates (e.g., nitroglycerin, isosorbide dinitrate) is absolutely contraindicated due to the risk of severe and potentially fatal hypotension (critically low blood pressure). This applies to both prescribed and recreational nitrates ("poppers").
• Alpha-blockers: Medications used to treat high blood pressure or enlarged prostate (e.g., doxazosin, tamsulosin) can cause a significant drop in blood pressure when combined with Sildenafil Citrate. Use with caution, and initiate Sildenafil at the lowest dose.
• CYP3A4 inhibitors: Drugs that inhibit the cytochrome P450 3A4 enzyme (e.g., ketoconazole, itraconazole, erythromycin, cimetidine, ritonavir, grapefruit juice) can increase Sildenafil levels in the blood, leading to an increased risk of side effects. Lower doses of Sildenafil may be required.
• CYP3A4 inducers: Conversely, drugs that induce CYP3A4 (e.g., rifampicin, carbamazepine, phenytoin) can decrease Sildenafil levels, potentially reducing its effectiveness.
• Other ED treatments: Combining Fildena Extra Power with other treatments for erectile dysfunction (oral or topical) is not recommended due to the lack of studies on safety and efficacy.

Drug-Food Interactions

• Grapefruit and Grapefruit Juice: Can increase the levels of Sildenafil Citrate in the body, potentially leading to an increased risk of side effects. It is advisable to avoid consuming grapefruit products while taking Fildena Extra Power.
• High-fat meals: Consuming Fildena Extra Power with a high-fat meal may delay the absorption of the drug, leading to a slower onset of action.

Use: Dosing, Missed Dose, Overdose

Dosing Information

Fildena Extra Power is typically available in higher strengths of Sildenafil Citrate. The recommended starting dose for most men with erectile dysfunction is usually 50 mg of Sildenafil Citrate, taken approximately 30 to 60 minutes before sexual activity. The dose may be adjusted based on efficacy and tolerability, up to a maximum recommended dose of 100 mg, or decreased to 25 mg. It is crucial not to exceed one dose per 24-hour period. The medication should be taken orally with water. The effect of the medication usually lasts for about 4-5 hours. Alcohol consumption should be limited, as it can temporarily impair the ability to get an erection and may increase the risk of side effects such as dizziness and headache.

Missed Dose

Fildena Extra Power is an "on-demand" medication, meaning it is taken only when needed, usually before sexual activity. Therefore, there is no regular dosing schedule, and the concept of a "missed dose" does not apply. Do not take more than one dose within a 24-hour period.

Overdose

Taking more than the recommended dose of Fildena Extra Power can increase the incidence and severity of side effects. Symptoms of an overdose may include severe dizziness, fainting, prolonged erection (priapism), chest pain, or vision changes. In case of a suspected overdose, seek immediate medical attention or contact emergency services. Supportive measures should be taken as clinically indicated. Renal dialysis is not expected to accelerate clearance as Sildenafil is highly bound to plasma proteins and not eliminated significantly in the urine.

Practical Precautions

• Alcohol: Excessive alcohol intake should be avoided when taking Fildena Extra Power, as it can exacerbate side effects like dizziness and reduce the drug's effectiveness.
• Food: While it can be taken with or without food, a heavy, high-fat meal might delay the onset of action.
• Driving/Operating Machinery: Due to potential side effects like dizziness and visual disturbances, caution should be exercised when driving or operating machinery after taking Fildena Extra Power, especially until you know how the medication affects you.

FAQ

• What is the maximum effective duration of Fildena Extra Power in the body? The effects of Fildena Extra Power, primarily driven by Sildenafil Citrate, typically last for approximately 4 to 5 hours. However, this duration can vary based on individual metabolism, dosage, and other physiological factors. It's important to remember that sexual stimulation is still required for an erection to occur within this window.

• Can Fildena Extra Power be taken daily for continuous effect? Fildena Extra Power is designed as an "on-demand" medication, intended for use as needed before sexual activity, not for daily continuous use. While Sildenafil Citrate in lower doses is approved for daily use in pulmonary arterial hypertension, this specific formulation is not indicated for that purpose, and daily use for ED carries different considerations.

• Are there any dietary restrictions other than grapefruit when using Fildena Extra Power? Beyond grapefruit and excessive alcohol, there are no strict universal dietary restrictions. However, consuming Fildena Extra Power with a very heavy or high-fat meal might delay its absorption, potentially leading to a slower onset of action. Light meals generally do not significantly impact absorption.

• How does Fildena Extra Power differ from other PDE5 inhibitors regarding its chemical structure? While all PDE5 inhibitors share a similar mechanism of action, Sildenafil Citrate, the active ingredient in Fildena Extra Power, has a distinct chemical structure that leads to specific pharmacological properties. These structural differences contribute to its particular onset, duration, and side effect profile compared to other PDE5 inhibitors like Tadalafil or Vardenafil.

• Can Fildena Extra Power be used by individuals with diabetes? Yes, Fildena Extra Power can be used by individuals with diabetes, provided that their diabetes is well-controlled and they have consulted with their healthcare provider. Erectile dysfunction is common in men with diabetes, and Sildenafil Citrate can be an effective treatment option. However, careful monitoring is advised due to potential interactions or cardiovascular considerations.

• What is the recommended storage for Fildena Extra Power? Fildena Extra Power should be stored at room temperature, ideally between 20°C to 25°C (68°F to 77°F), away from moisture, heat, and direct light. It should be kept in its original packaging and out of reach of children and pets to maintain its efficacy and safety.

• Does Fildena Extra Power affect fertility or sperm quality? Current research and clinical data generally indicate that Sildenafil Citrate, when used as prescribed, does not negatively impact male fertility or sperm quality. Some studies have even explored potential positive effects on sperm motility, but definitive conclusions remain subject to further research.

• Is there a specific time of day when Fildena Extra Power is most effective? There is no specific time of day that makes Fildena Extra Power inherently more effective. Its efficacy is primarily linked to its ingestion approximately 30 to 60 minutes before anticipated sexual activity, irrespective of the time of day. The timing should simply coincide with when its effects are desired.

• Can Fildena Extra Power be crushed or split for easier consumption? It is generally not recommended to crush or split Fildena Extra Power tablets unless specifically instructed by a healthcare professional or if the tablet is scored for that purpose. Altering the tablet's form can affect its absorption rate, leading to either reduced efficacy or an increased risk of side effects.

• Are there any known interactions between Fildena Extra Power and herbal supplements? While specific interactions are not always well-documented for all herbal supplements, caution is advised. Some herbal remedies, particularly those marketed for sexual enhancement (e.g., Yohimbe), or those affecting blood pressure or liver enzymes (e.g., St. John's Wort), could potentially interact with Sildenafil Citrate. Always disclose all supplements to your doctor.

Glossary

Erectile Dysfunction (ED)

The consistent inability to achieve or maintain an erection firm enough for satisfactory sexual intercourse.

Phosphodiesterase type 5 (PDE5) Inhibitor

A class of medications that block the action of the PDE5 enzyme, leading to increased levels of cGMP and smooth muscle relaxation.

Sildenafil Citrate

The active pharmaceutical ingredient in Fildena Extra Power, responsible for its therapeutic effects, by inhibiting the PDE5 enzyme.

Pulmonary Arterial Hypertension (PAH)

A type of high blood pressure that affects the arteries in the lungs and the right side of the heart.

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Disclaimer

The information provided about Fildena Extra Power is for general knowledge purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. All decisions regarding treatment, including any consideration of off-label use, must be made under the direct supervision of a qualified healthcare provider. We maintain that all readers are responsible adults capable of making informed choices about their health. Our online pharmacy facilitates access to Fildena Extra Power for individuals experiencing limited availability through conventional pharmacies, prescription-based insurance plans, or those seeking affordable generic alternatives. Always consult your doctor before initiating, modifying, or discontinuing any medication.