--- title: Buy Diclegis (Doxylamine, Pyridoxine) 10/10mg Tabs description: Diclegis 10/10mg Tabs is a trusted treatment for nausea and vomiting in pregnancy. Shop our secure online pharmacy for verified quality and shipping. type: product language: en url: https://medsforsale.net/buy-diclegis-online-en availability: in_stock price_min: 72.99 price_max: 328.99 currency: USD offers: - name: 10/10mg x 30 tabs price: 72.99 - name: 10/10mg x 60 tabs price: 127.99 - name: 10/10mg x 90 tabs price: 183.99 - name: 10/10mg x 120 tabs price: 228.99 - name: 10/10mg x 180 tabs price: 328.99 --- # Buy Diclegis (Doxylamine, Pyridoxine) 10/10mg Tabs Diclegis is a specialized combination of Doxylamine succinate and Pyridoxine (Vitamin B6) specifically designed to manage morning sickness. This medication provides a delayed-release formula to help minimize nausea and vomiting effectively throughout the day. It is the preferred choice for expectant mothers whose symptoms are not managed by lifestyle changes alone. Our online pharmacy offers a reliable supply of Diclegis in 10/10mg tabs. ## Pricing and Options | Dosage | Pack Size | Price (USD) | Price Per Pill | Status | | :--- | :--- | :--- | :--- | :--- | | **10/10mg** | 30 tabs | **$72.99** | $2.43 | In Stock | | **10/10mg** | 60 tabs | **$127.99** | $2.13 | In Stock | | **10/10mg** | 90 tabs | **$183.99** | $2.04 | In Stock | | **10/10mg** | 120 tabs | **$228.99** | $1.91 | In Stock | | **10/10mg** | 180 tabs | **$328.99** | $1.83 | In Stock | [Buy Now](https://medsforsale.net/buy-diclegis-online-en) ## Introduction Diclegis is an oral tablet that combines 10 mg of doxylamine succinate with 10 mg of pyridoxine (vitamin B6). It is classified as a fixed-dose combination antihistamine-vitamin product and is approved by the U.S. Food and Drug Administration (FDA) for the treatment of nausea and vomiting of pregnancy (NVP), sometimes called morning sickness. The medication is manufactured by Mallinckrodt Pharmaceuticals and is supplied in a 10/10 mg tablet form. In addition to its primary indication, limited clinical evidence has examined off-label uses such as adjunctive therapy for sleep disturbance and certain migraine-related nausea, though these applications are not formally approved. ## What is Diclegis? Diclegis is a prescription-only tablet that contains the antihistamine doxylamine succinate paired with the vitamin pyridoxine. The product was developed to address NVP after research demonstrated that the two agents act synergistically to reduce pregnancy-related nausea. Diclegis is marketed under brand names such as Diclegis and the historic formulation Bendectin. [our online pharmacy](https://medsforsale.net/buy-diclegis-online-en) provides this combination as a generic alternative, offering a cost-effective option for patients who meet the prescribing criteria. ## How Diclegis Works Doxylamine succinate blocks histamine H₁ receptors in the central nervous system, producing a sedative effect that diminishes the vomiting reflex. Pyridoxine participates in neurotransmitter synthesis and has been shown to modulate nausea pathways, possibly by influencing serotonin metabolism. When combined, doxylamine’s antihistaminic action and pyridoxine’s anti-nausea effect produce a faster onset of relief-typically within 30 minutes-lasting up to 8 hours. The drug is eliminated primarily by renal excretion, with a half-life of about 10 hours for doxylamine and 3 hours for pyridoxine. ## Conditions Treated with Diclegis - **Nausea and vomiting of pregnancy (NVP).** Clinical trials involving more than 1,600 pregnant women demonstrated a statistically significant reduction in vomiting episodes and improvement in nausea severity compared with placebo (FDA prescribing information, 2020). The medication is recommended for women who have not achieved adequate control with lifestyle measures alone. ## Off-Label and Investigational Uses of Diclegis - **Sleep disturbance in non-pregnant adults.** Small open-label studies have reported that the doxylamine component can improve sleep latency, although the formulation is not approved for insomnia and safety in long-term use remains uncertain. - **Adjunctive treatment of migraine-associated nausea.** Observational data suggest that the antihistamine portion may reduce nausea when added to standard migraine therapy, but controlled trials are lacking. These applications have not received regulatory approval. Patients should only consider off-label use after a thorough discussion with a qualified healthcare provider, who can assess benefit-risk balance and monitor for adverse effects. ## Is Diclegis the Right Medication for You? Diclegis is most appropriate for pregnant individuals experiencing moderate to severe NVP after dietary measures (e.g., small frequent meals, ginger) and vitamin B6 monotherapy have failed. It is contraindicated in patients with known hypersensitivity to doxylamine, pyridoxine, or any excipients, and should be avoided in those with severe hepatic impairment or active seizure disorders. Women who are using monoamine oxidase inhibitors (MAOIs) or who have a history of severe depression should discuss alternatives, as doxylamine may potentiate central nervous system depression. ## Risks, Side Effects, and Interactions ### Common - Drowsiness - Dry mouth - Constipation ### Rare - Visual disturbances (blurred vision) - Palpitations ### Serious - Allergic reactions (rash, urticaria, angioedema, anaphylaxis) - Hepatotoxicity (very rare, reported in isolated case studies) #### Drug-Drug Interactions - **Alcohol and other sedatives:** Potentiate central nervous system depression, increasing drowsiness and impairing coordination. - **Monoamine oxidase inhibitors (MAOIs):** May enhance antihistamine effects, leading to excessive sedation. - **Anticholinergic agents (e.g., diphenhydramine):** Additive dry-mouth and constipation risk. #### Drug-Food Interactions - Grapefruit juice can modestly increase plasma concentrations of doxylamine; patients should limit consumption. - High-dose vitamin B6 supplements may raise pyridoxine levels, potentially causing peripheral neuropathy with prolonged use. ## Use: Dosing, Missed Dose, Overdose - **Standard dosing:** One tablet (10 mg/10 mg) once daily at bedtime. For patients who do not achieve sufficient relief, the prescriber may increase to a maximum of two tablets per day, taken at least 8 hours apart. - **Missed dose:** If a dose is forgotten, take it as soon as remembered unless it is close to the time of the next scheduled dose. In that case, skip the missed dose; do not double-dose. - **Overdose:** Symptoms may include profound sedation, respiratory depression, and hypotension. Seek emergency medical care immediately. Activated charcoal may be considered if presentation occurs within one hour of ingestion. **Practical precautions:** Take Diclegis with a full glass of water. Avoid alcohol and operating heavy machinery or driving until the individual’s response to the medication is known. ## FAQ - **What should I do if I experience severe drowsiness while taking Diclegis?** *If drowsiness interferes with daily activities, consider adjusting the dosing time to earlier in the evening or discuss a dose reduction with a healthcare professional. Persistent excessive sedation warrants medical evaluation.* - **Can I travel internationally with Diclegis in my carry-on luggage?** *Yes, it is permissible to carry the medication in its original prescription container, accompanied by a copy of the prescribing documentation. Some countries may require additional declaration, so checking the destination’s import regulations beforehand is advisable.* - **How does temperature affect the stability of Diclegis tablets?** *The product should be stored at room temperature, between 20 °C and 25 °C (68 °F-77 °F). Exposure to temperatures above 30 °C (86 °F) for extended periods may degrade the active ingredients, reducing efficacy.* - **Are there any animal-derived ingredients in the formulation?** *Diclegis tablets contain lactose monohydrate as an inactive ingredient; they do not contain gelatin, animal-derived fats, or other common allergens. Patients with lactose intolerance should consult a provider, although the amount is generally low.* - **What is the appearance of a Diclegis tablet?** *Each tablet is round, white, and scored for ease of splitting. The imprint reads “D-10/10” on one side and “MALL” on the opposite side.* - **Is a urine drug test affected by taking Diclegis?** *Doxylamine and pyridoxine are not screened for in standard employment or legal drug testing panels, so routine urine tests will not detect the medication.* - **Can I take Diclegis while breastfeeding?** *Limited data suggest that doxylamine and pyridoxine are excreted in breast milk in very low concentrations. The American Academy of Pediatrics considers the medication compatible with breastfeeding, but a clinician should evaluate the infant’s tolerance.* - **How long can Diclegis be used during pregnancy?** *Clinical studies have evaluated safety through the third trimester. Most guidelines advise continuation until symptoms subside, but long-term use beyond 12 weeks should be reassessed by a provider.* - **What distinguishes Diclegis from over-the-counter sleep aids?** *Diclegis combines an antihistamine with vitamin B6, targeting nausea as well as sedation, whereas most OTC sleep aids contain only antihistamines. The specific dosing ratio of 10 mg/10 mg is unique to the prescription formulation.* - **Is Diclegis covered by health-insurance plans in the United States?** *Coverage varies by insurer and policy. Some plans list the medication under “Nausea and Vomiting of Pregnancy” benefits, while others may require prior authorization. Patients should verify their specific benefits.* ## Glossary **Antihistamine** : A drug that blocks histamine H₁ receptors, reducing allergic reactions and, in the case of doxylamine, producing sedation that can diminish nausea. **Synergistic effect** : When two agents work together to produce a therapeutic outcome greater than the sum of their individual effects. **Renal excretion** : The process by which the kidneys eliminate substances from the bloodstream into the urine; the primary clearance route for doxylamine and pyridoxine. **Half-life** : The time required for the plasma concentration of a drug to decrease by 50 %; for doxylamine it is approximately 10 hours. ## Buying Diclegis from [our online pharmacy](https://medsforsale.net/buy-diclegis-online-en) Diclegis is available for purchase through [our online pharmacy](https://medsforsale.net/buy-diclegis-online-en), which sources the medication from licensed, vetted suppliers abroad. By operating as a pharmacy broker service, we can offer the tablet at a price close to the manufacturer’s list cost, helping patients who face high out-of-pocket expenses or limited local availability. All shipments are packaged discreetly and delivered through a secure logistics network, with typical express delivery within 7 days and standard airmail arriving in approximately 3 weeks. Our verification process ensures that each batch meets stringent quality standards, providing confidence in the safety and efficacy of the product while respecting patient privacy throughout the transaction. ## Disclaimer The information presented about Diclegis is intended for general educational purposes and does not substitute professional medical advice. Treatment decisions, including any off-label applications, must be made under the supervision of a qualified healthcare provider. Readers are assumed to be responsible adults capable of making informed health choices. [our online pharmacy](https://medsforsale.net/buy-diclegis-online-en) offers access to Diclegis for individuals who may encounter limited availability through conventional pharmacies or insurance-based distribution channels and who seek a cost-effective generic alternative. Always discuss any medication changes with a qualified clinician before initiating, adjusting, or terminating therapy.