Generic Acyclovir Cream 5% (Acyclovir)

Introduction

Acyclovir cream 5 % is a topical antiviral formulation that contains the nucleoside analogue acyclovir as its sole active ingredient. It is supplied in tubes of 5 g or 10 g and is classified as a prescription-only dermatologic medication. The cream is indicated for the topical treatment of external lesions caused by herpes simplex virus (HSV) infections in adults. In addition to its approved uses, some clinicians employ the preparation off-label for recurrent or atypical HSV presentations.

What is Acyclovir cream 5 %?

Acyclovir cream 5 % is a semi-solid, white to off-white ointment that delivers 5 % (weight/weight) acyclovir to the skin. The product belongs to the antiviral drug class and is a synthetic analogue of the nucleoside guanosine.

The formulation was first approved by the U.S. Food and Drug Administration (FDA) in the early s for the treatment of genital herpes and cold-sores. While the original manufacturer varies by region, the cream is now widely produced by multiple certified pharmaceutical companies under generic licences.

Acyclovir cream 5 % is the generic version of well-known medications, containing the active compound acyclovir. Our online pharmacy provides this generic alternative as a cost-effective treatment option. It is marketed under brand names such as Zovirax and Aciclovir in several countries.

How Acyclovir cream 5 % Works

Acyclovir is a prodrug that is phosphorylated by viral thymidine kinase to acyclovir-monophosphate. Host cellular kinases further convert it to the active triphosphate form. Acyclovir-triphosphate competitively inhibits viral DNA polymerase and incorporates into viral DNA, causing chain termination and preventing viral replication.

When applied topically, the drug penetrates the stratum corneum and reaches the infected keratinocytes. The onset of therapeutic activity usually occurs within 24 hours, with maximal viral suppression observed after 2-4 days of continuous application. Acyclovir is eliminated primarily by renal excretion; systemic absorption from the cream is minimal, limiting systemic side effects.

Conditions Treated with Acyclovir cream 5 %

• Herpes labialis (cold-sores) - External lesions on the lips or perioral skin caused by HSV-1. The antiviral reduces lesion duration, pain, and viral shedding when initiated within 48 hours of symptom onset.
• Genital herpes (HSV-2) external lesions - Primary or recurrent vesicular eruptions on the external genitalia. Topical therapy shortens healing time and alleviates discomfort.

The efficacy of acyclovir cream for these indications is supported by randomized, double-blind trials published in peer-reviewed journals (e.g., Clinical Therapeutics, 1992; British Journal of Dermatology, 1996).

Off-Label and Investigational Uses of Acyclovir cream 5 %

• Prophylactic treatment of recurrent HSV lesions - Some dermatologists prescribe acyclovir cream for intermittent use during prodromal symptoms to prevent full-blown outbreaks. Small open-label studies suggest reduced recurrence frequency, but larger controlled trials are lacking.
• Eczema herpeticum - A severe HSV infection superimposed on atopic dermatitis. Topical acyclovir may be used adjunctively with systemic antivirals, although clinical guidance recommends systemic therapy as primary treatment.
• Herpes zoster (shingles) in localized dermatomal eruptions - Rarely, clinicians employ the cream on limited cutaneous zones when oral antivirals are contraindicated. Evidence is limited to case reports.

These applications are not approved by regulatory agencies such as the FDA or EMA. Patients should consider off-label use only under direct supervision of a qualified healthcare professional.

Is Acyclovir cream 5 % the Right Medication for You?

Acyclovir cream 5 % is appropriate for adult patients who present with external HSV lesions (labial or genital) and who prefer a topical approach or have contraindications to systemic antivirals. It is particularly useful when:

• Lesions are localized and superficial.
• Patients have mild to moderate pain and seek rapid symptom relief.
• There is a need to avoid systemic drug exposure (e.g., renal impairment).

Contraindications include:

• Known hypersensitivity to acyclovir or any formulation component.
• Extensive mucosal involvement (e.g., oral mucosa) where systemic therapy is indicated.
• Pregnancy or lactation: topical use is considered low risk, but clinicians should weigh benefits against potential fetal exposure.

Risks, Side Effects, and Interactions

Common

• Local skin irritation (burning, itching, or stinging at the application site).
• Erythema or mild edema.

Rare

• Contact dermatitis mediated by an allergic reaction to the cream base.
• Secondary bacterial infection of the treated area if the skin barrier is compromised.

Serious

• Systemic hypersensitivity reactions (e.g., urticaria, angioedema) are exceedingly rare due to minimal absorption but require immediate medical attention.

Drug-Drug Interactions

• Topical acyclovir has no clinically relevant interactions with systemic medications because systemic concentrations are negligible.
• Concomitant use of other topical agents (e.g., corticosteroids, retinoids) may increase local irritation; spacing applications is advisable.

Drug-Food Interactions

• No known interactions with food or beverages.

Use: Dosing, Missed Dose, Overdose

• Standard dosing: Apply a thin layer of the cream to the affected area 5 times daily (approximately every 4 hours) for 4 days. Treatment may be extended up to 7 days for severe lesions.
• Missed dose: If a dose is forgotten, apply it as soon as remembered unless the next scheduled dose is within 2 hours; in that case, skip the missed dose and resume the regular schedule.
• Overdose: Accidental ingestion of a large amount of cream is unlikely to cause systemic toxicity. If ingestion occurs, observe the patient for gastrointestinal irritation and seek medical advice if symptoms develop.
• Precautions:
  • Wash hands before and after application.
  • Do not apply to mucous membranes, eyes, or open wounds.
  • Avoid contact with heat sources (e.g., hot tubs) that may enhance skin absorption.
  • Operating heavy machinery is not restricted; however, if local irritation impairs vision or dexterity, caution is advised.

FAQ

• What is the optimal temperature for storing Acyclovir cream 5 %?

  • The cream should be kept at room temperature, ideally between 15 °C and 30 °C (59 °F - 86 °F). Exposure to extreme heat or freezing may affect the consistency and potency.

• Can I travel internationally with a tube of Acyclovir cream?

  • Yes, the cream complies with most customs regulations for personal medication. Carry the original packaging and a copy of the prescription or medical documentation to avoid delays.

• Does the cream contain any preservatives that might cause allergies?

  • Most generic formulations include inert excipients such as parabens or methylparaben. Patients with known sensitivities should review the ingredient list provided by the supplier.

• How does the cream differ from oral acyclovir tablets?

  • Topical acyclovir delivers the drug directly to the lesion, resulting in low systemic exposure and fewer systemic side effects. Oral tablets provide higher plasma concentrations, useful for extensive or mucosal infections.

• Is the 5 % concentration the same worldwide?

  • Regulatory agencies in the United States, European Union, and many Asian countries approve a 5 % (w/w) concentration for topical use. Some regions may market a 3 % formulation for specific indications.

• Will the cream affect a drug test?

  • Because systemic absorption is minimal, topical acyclovir is unlikely to be detected in standard urine or blood drug panels.

• Can I apply the cream under a bandage?

  • Yes, covering the treated area with a non-occlusive dressing can enhance drug contact time, but avoid airtight occlusion that may increase skin irritation.

• What is the shelf life of a 5 g tube versus a 10 g tube?

  • Both tube sizes typically have a shelf life of 24 months when stored properly. The expiration date is printed on the label; do not use the product after this date.

• Is the cream suitable for use on children?

  • The formulation is approved for adult use only. Pediatric application should be directed by a pediatrician, as dosing and safety data are limited.

• How does Acyclovir cream compare to other topical antivirals like penciclovir?

  • Penciclovir 1 % cream also treats HSV lesions but requires a longer treatment course (7 days). Comparative studies suggest similar efficacy, though acyclovir may have a slightly faster onset of symptom relief.

Glossary

Thymidine kinase

An enzyme produced by herpes viruses that phosphorylates nucleoside analogues like acyclovir, initiating their activation inside infected cells.

Triphosphate form

The active metabolite of acyclovir after three sequential phosphorylation steps; it inhibits viral DNA polymerase.

Prodrome

Early signs or symptoms (such as tingling or itching) that precede the appearance of a herpes lesion.

Buying Acyclovir cream 5 % from Our Online pharmacy

Patients who have difficulty obtaining Acyclovir cream 5 % through local pharmacies or insurance formularies can purchase the medication from our online pharmacy.

• Affordable pricing - We source the generic product directly from licensed manufacturers, allowing us to offer prices close to the manufacturer’s cost without compromising quality.
• Verified quality - Every tube is supplied by a vetted, internationally accredited pharmacy that adheres to Good Manufacturing Practice (GMP) standards. Independent third-party testing confirms potency and purity.
• Discreet and reliable delivery - Packages are shipped in neutral packaging, with tracking available for all orders. Standard shipping typically arrives within 7 days (express) or 3 weeks (regular airmail), depending on the destination.
• Online-only access - Our service connects you to overseas licensed pharmacies, enabling access to medications that may not be stocked locally. This model ensures privacy while maintaining regulatory compliance.

By choosing our pharmacy broker service, patients receive a secure, cost-effective pathway to the antiviral treatment they need, especially when conventional channels are limited.

Disclaimer

The information provided about Acyclovir cream 5 % is for general knowledge only. It does not replace professional medical consultation. All treatment decisions, including those regarding off-label use, should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Acyclovir cream 5 % for individuals who may have limited availability through traditional pharmacies, prescription-based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.